Abstract
Craniopharyngiomas and pituitary adenomas are both tumors of the hypothalamic and pituitary region, respectively that are frequently associated with endocrine defects either because of direct involvement of hormone producing cells (most pituitary tumors) or because of secondary defects due to disturbance of hypothalamic function (some pituitary tumors and craniopharyngiomas). Some studies suggest that mutant β-catenin gene cells in craniopharyngiomas and pituitary adenomas contribute to their tumorigenesis. DNA was extracted from 73 cranial tumors and subjected to polymerase chain reaction (PCR) with previously described primers encompassing glycogen synthase kinase-3β phosphorylation sites of the β-catenin gene. Sequenced PCR products for possible β-catenin gene mutations showed a total of 7/43 alterations in adamantinomatous craniopharyngioma-derived DNA samples. Two previously described β-catenin mutations in codon 33 TCT(Ser) > TGT(Cys) and codon 37 TCT(Ser) > TTT(Phe), whereas three novel mutations in codon 41 ACC(Thr) > ATC(Ile), codon 33 TCT(Ser) > TAT(Tyr) and codon 32 GAC(Asp) > AAC(Asn) were observed. None of the 22 pituitary adenomas and the eight papillary craniopharyngiomas analyzed presented any sequence alterations. These findings demonstrate an association between β-catenin gene alterations and craniopharyngiomas of the adamantinomatous type. Since this gene product is involved with development, these results suggest that β-catenin mutations may contribute to the initiation and subsequent growth of congenital craniopharyngiomas.
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References
R Kemler M. Ozawa (1989) ArticleTitleUvomorulin–catenin complex: Cytoplasmic anchorage of a Ca2+-dependent cell adhesion molecule BioEssays 4 88–91 Occurrence Handle10.1002/bies.950110403
A Kispert S Vainio AP. McMahon (1998) ArticleTitleWnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney Development 21 4225–4234
M. Takeichi (1991) ArticleTitleCadherin cell adhesion receptors as a morphogenetic regulator Science 251 1451–1455 Occurrence Handle1:CAS:528:DyaK3MXhvVSnsbg%3D Occurrence Handle2006419
PJ. Morin (1999) ArticleTitleBeta-catenin signaling and cancer BioEssays 12 1021–1030 Occurrence Handle10.1002/(SICI)1521-1878(199912)22:1<1021::AID-BIES6>3.0.CO;2-P
A. Kikuchi (2000) ArticleTitleRegulation of beta-catenin signaling in the Wnt pathway Biochem Biophys Res Commun 2 243–248 Occurrence Handle10.1006/bbrc.1999.1860
A. Kikuchi (2003) ArticleTitleTumor formation by genetic mutations in the components of the Wnt signaling pathway Cancer Sci 3 225–229
S Semba SY Han H Ikeda A. Horii (2001) ArticleTitleFrequent nuclear accumulation of β-catenin in pituitary adenoma Cancer 91 42–48 Occurrence Handle10.1002/1097-0142(20010101)91:1<42::AID-CNCR6>3.0.CO;2-7 Occurrence Handle1:CAS:528:DC%2BD3MXot1GltA%3D%3D Occurrence Handle11148558
S Sekine T Shibata A Kokubu YM Masayuki NN Yukihiro M Sakamoto S. Hirohashi (2002) ArticleTitleCraniopharyngiomas of adamantinomatous type harbor β-catenin gene mutations Am J Pathol 161 1997–2001 Occurrence Handle1:CAS:528:DC%2BD38Xpslemtbg%3D Occurrence Handle12466115
BW Scheithauer E Horvath K. Kovacs (1986) ArticleTitlePlurihormonal pituitary adenomas Semin Diagn Pathol 3 69–82 Occurrence Handle1:STN:280:BiiB1M7jtVA%3D Occurrence Handle3039632
HL Weiner JH Wisoff ME Rosenberg MJ Kupersmith H Cohen D Zagzag T Shiminski-Maher ES Flamm FJ Epstein DC. Miller (1994) ArticleTitleCraniopharyngiomas: A clinicopathological analysis of factors predictive of recurrence and functional outcome Neurosurgery 6 1001–1011
Y Kajino A Yamaguchi N Hashimoto A Matsuura N Sato K. Kikuchi (2001) ArticleTitleBeta-catenin gene mutation in human hair follicle-related tumors Pathol Int 7 543–548 Occurrence Handle10.1046/j.1440-1827.2001.01231.x
P. Polakis (2000) ArticleTitleWnt signaling and cancer Gene Dev 15 1837–1845
E Van Aken O De Wever AS Correia da Rocha M. Mareel (2001) ArticleTitleDefective E-cadherin/catenin complexes in human cancer Virchows Arch 439 725–751 Occurrence Handle1:CAS:528:DC%2BD3MXoslSmtbw%3D Occurrence Handle11787845
T Trandafir C Sipot P. Froicu (1990) ArticleTitleOn a possible neural ridge origin of the adenohypophysis Endocrinologie 28 67–72 Occurrence Handle1:STN:280:By6C2MnpsVM%3D Occurrence Handle2293330
TT Takor AGE. Peause (1975) ArticleTitleNeuroectodermal origin of hypothalamo-hypophyseal complex: the role of the ventral neural ridge J Embryol Exp Morphol 34 311–325 Occurrence Handle1:STN:280:CSmD2s%2FmvVQ%3D Occurrence Handle1194833
ZR Qian CC Li H Yamasaki N Mizusawa K Yoshimoto S Yamada T Tashiro H Horiguchi S Wakatsuki M Hirokawa T Sano (2002) ArticleTitleRole of E-cadherin, alpha-, beta-, and gamma-catenins, and p120 (cell adhesion molecules) in prolactinoma behavior Mod Pathol 12 1357–1365 Occurrence Handle10.1097/01.MP.0000039572.75188.1A
K Thapar K Kovacs (1988) Neoplasms of the cellar region DD Binger RE McLendon JM Bruner (Eds) Russel and Rubinstein’s Pathology of Tumors on the Nervous System 6th edn. Arnord London 629–680
TB Crotty BW Scheithauer WF Young SuffixJr DH Davis EG Shaw GM Miller PC. Burger (1995) ArticleTitlePapillary craniopharyngioma: A clinicopathological study of 48 cases J Neurosurg Sci 2 206–214
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Oikonomou, E., Barreto, D.C., Soares, B. et al. β-catenin mutations in craniopharyngiomas and pituitary adenomas. J Neurooncol 73, 205–209 (2005). https://doi.org/10.1007/s11060-004-5232-z
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DOI: https://doi.org/10.1007/s11060-004-5232-z