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MRI based on iron oxide nanoparticles contrast agents: effect of oxidation state and architecture

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Abstract

Iron oxide nanoparticles (IONPs) extensively employed beyond regenerative medicines to imaging disciplines because of their great constituents for magneto-responsive nano-systems. The unique superparamagnetic behavior makes IONPs very suitable for hyperthermia and imaging applications. From the last decade, versatile functionalization with surface capabilities, efficient contrast properties and biocompatibilities make IONPs an essential imaging contrast agent for magnetic resonance imaging (MRI). IONPs have shown signals for both longitudinal relaxation and transverse relaxation; therefore, negative contrast as well as dual contrast can be used for imaging in MRI. In the current review, we have focused on different oxidation state of iron oxides, i.e., magnetite, maghemite and hematite for their T1 and T2 contrast enhancement properties. We have also discussed different factors (synthesis protocols, biocompatibility, toxicity, architecture, etc.) that can affect the contrast properties of the IONPs.

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Acknowledgements

The authors acknowledge the Higher Education Commission Pakistan for financial support under NRPU project No. 6411.

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  1. Department of Physics, University of Agriculture, University Main Rd, Faisalabad, 38000, Pakistan

    Yasir Javed, Kanwal Akhtar, Hafeez Anwar & Yasir Jamil

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Javed, Y., Akhtar, K., Anwar, H. et al. MRI based on iron oxide nanoparticles contrast agents: effect of oxidation state and architecture. J Nanopart Res 19, 366 (2017). https://doi.org/10.1007/s11051-017-4045-x

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