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Evaluation of an oral carrier system in rats: bioavailability and gastrointestinal absorption properties of curcumin encapsulated PBCA nanoparticles

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Abstract

A new oral delivery system, polybutylcyanoacrylate nanoparticles (PBCNs), was introduced to improve the oral bioavailability of curcumin (CUR), a poorly soluble drug. The formulation was optimized by orthogonal design and the optimal PBCNs loading CUR exhibited a spherical shape under transmission electron microscopy with a range of 40–400 nm. Physicochemical state of CUR in PBCN was investigated by X-ray diffraction and the possible structure changes occurring in CUR after conjugating with polybutylcyanoacrylate were studied with FTIR. The results indicated that CUR in PBCN was in a non-crystalline state and CUR was encapsulated in PBCN without chemical reaction. The oral pharmacokinetic study was conducted in rats and the relative bioavailability of CUR encapsulated PBCNs to the crude CUR was more than 800%. The in situ absorption experiment in rat intestine indicated the absorption was first order with passive diffusion mechanism. The absorption results in various segments of intestine showed that the main absorption sites were ileum and colon. It can be concluded that PBCNs as an oral carrier can significantly improve the oral absorption of a poorly soluble drug.

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Acknowledgment

This work is partly supported by the National Natural Science Foundation of China (No. 30973646).

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Authors and Affiliations

  1. Department of Pharmaceutics, College of Pharmacy, Shandong University, 44 Wenhua Xilu, Jinan, 250012, China

    Min Sun, Lixia Zhao, Chenyu Guo, Fengliang Cao, Huanlei Chen, Liyan Zhao, Qi Tan, Xiuqing Zhu, Fanping Zhu, Tingting Ding, Yingjie Zhai & Guangxi Zhai

  2. Department of Pharmacy, Central Hospital of Zibo, Zibo, 255036, China

    Min Sun

  3. Department of Pharmacy, Qilu Hospital of Shandong University, Jinan, 250012, China

    Lixia Zhao

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  1. Min Sun
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  2. Lixia Zhao
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  3. Chenyu Guo
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  4. Fengliang Cao
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  5. Huanlei Chen
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  6. Liyan Zhao
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  7. Qi Tan
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  8. Xiuqing Zhu
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  9. Fanping Zhu
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  10. Tingting Ding
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  11. Yingjie Zhai
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  12. Guangxi Zhai
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Correspondence to Guangxi Zhai.

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Min Sun and Lixia Zhao contributed equally to this work.

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Sun, M., Zhao, L., Guo, C. et al. Evaluation of an oral carrier system in rats: bioavailability and gastrointestinal absorption properties of curcumin encapsulated PBCA nanoparticles. J Nanopart Res 14, 705 (2012). https://doi.org/10.1007/s11051-011-0705-4

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