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Plasma kinetics and biodistribution of water-soluble CdTe quantum dots in mice: a comparison between Cd and Te

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Abstract

Water-soluble quantum dots (QDs) have shown potential as tumor diagnostic agents. However, little is known about their biological behaviors in vivo. Male ICR mice were intravenously given a single dose (2.5 μmol kg−1 body weight) of water-soluble cadmium–telluride (CdTe) QDs (the QDs are approximately 4 nm in diameter and have maximal emission at 630 nm). Inductively coupled plasma mass spectrometry (ICP-MS) was used for measuring the kinetic action of 111Cd and 125Te for 7 days. The plasma kinetics of Cd and Te followed a two-compartment model, in which Cd exhibited greater apparent volume of distribution, greater clearance, faster distribution half-life, and significantly slower elimination half-life compared to Te. Contrary to its relatively transient fate in the plasma, high levels of Cd persisted in the liver and kidneys. Te accumulated primarily in the spleen. The different plasma kinetics and distribution patterns of Cd and Te imply that CdTe QDs have been part of the degradation or aggregation in vivo.

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Acknowledgments

This study was supported by the National Key Technologies Research & Development Program of China (No.2006BAK03A09), National Basic Research Program of China (No.2007CB714503), and the Science and Technology Development Program of Jilin Province (No.20060706).

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Authors and Affiliations

  1. Department of Toxicology and Sanitary Chemistry, School of Public Health and Family Medicine, Capital Medical University, No.10 Xitoutiao, You An Men, Beijing, 100069, People’s Republic of China

    Ying Han, Guangyun Xie, Zhiwei Sun, Yang Xiao, Na Liu, Hui Wang, Caixia Guo, Zhixiong Shi, Yanbo Li & Peili Huang

  2. Institute for Occupational Health and Poisoning Control, Chinese Center for Disease Control and Prevention, Beijing, 100013, China

    Guangyun Xie

  3. Research Center for Analytical Instrumentation, State Key Lab. of Industrial Control Technology, Institute of Cyber-Systems and Control, Zhejiang University, Hangzhou, 310058, China

    Ying Mu & Sihai Han

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  1. Ying Han
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  2. Guangyun Xie
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Correspondence to Peili Huang.

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Han, Y., Xie, G., Sun, Z. et al. Plasma kinetics and biodistribution of water-soluble CdTe quantum dots in mice: a comparison between Cd and Te. J Nanopart Res 13, 5373–5380 (2011). https://doi.org/10.1007/s11051-011-0523-8

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  • DOI: https://doi.org/10.1007/s11051-011-0523-8

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