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Onychomycosis Incidence in Type 2 Diabetes Mellitus Patients

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Abstract

The onychomycosis incidence was determined in 250 type 2 diabetes mellitus (T2DM) patients who were registered at the Internal Medicine Service from a Mexico city General Hospital throughout a year (January–December 2006). Out of the total of studied T2DM patients, 93 (37.2%) showed ungual dystrophy and from these, in 75.3% a fungal etiology was corroborated. Out of 70 patients, 34 were men and 36 women, with an average of 63.5 years. Correlation between T2DM evolution time and onychomycosis was significant (P < 0.01). Distal-lateral subungual and total dystrophic onychomycosis were the most frequent clinical types (55.1% and 33.7%, respectively). Fifty-eight fungal isolates were obtained; 48.6% corresponded to dermatophytes, Trichophyton rubrum being the first species (37.1%). All these strains corresponded to two morphological varieties: “yellow” and typical downy. From the yeast-like isolates, 12 corresponded to Candida spp., firstly C. albicans and C. parapsilosis; three to Cryptococcus spp. (C. albidus, C. uniguttulatus and C. laurentii); two Trichosporon asahii; and only one to Pichia ohmeri. Six non-dermatophytic molds were isolated: two Chrysosporium keratinophylus, two Scopulariopsis brevicaulis, one Aspergillus fumigatus, and one Acremonium sp. The fungal mixture corresponded to T. mentagrophytes with C. guilliermondii; T. mentagrophytes with C. glabrata; T. rubrum with C. glabrata; T. rubrum with P. ohmeri.

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Acknowledgment

We wish to acknowledge Ricardo Orozco for his technical assistance in the translation of this document.

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Authors and Affiliations

  1. Laboratorio de Micología Médica, Departamento de Microbiología y Parasitología, Facultad de Medicina, UNAM, Ciudad Universitaria, Mexico, CP 04510, DF, Mexico

    Patricia Manzano-Gayosso, Francisca Hernández-Hernández, Erika Córdova-Martínez, Elva Bazán-Mora & Rubén López-Martinez

  2. Unidad de Investigación Médica en Dermatología y Micología “Dr. Ernesto Macotela”, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, IMSS, Mexico, DF, Mexico

    Luis Javier Méndez-Tovar

  3. Servicio de Medicina Interna, Hospital General Dr. “Darío Fernández Fierro”, ISSSTE, Mexico, DF, Mexico

    Yanni Palacios-Morales

Authors
  1. Patricia Manzano-Gayosso
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  2. Francisca Hernández-Hernández
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  3. Luis Javier Méndez-Tovar
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  6. Elva Bazán-Mora
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  7. Rubén López-Martinez
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Correspondence to Patricia Manzano-Gayosso.

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Manzano-Gayosso, P., Hernández-Hernández, F., Méndez-Tovar, L.J. et al. Onychomycosis Incidence in Type 2 Diabetes Mellitus Patients. Mycopathologia 166, 41–45 (2008). https://doi.org/10.1007/s11046-008-9112-5

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  • DOI: https://doi.org/10.1007/s11046-008-9112-5

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