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Dependence between estrogen sulfotransferase (SULT1E1) and nuclear transcription factor Nrf-2 regulations via oxidative stress in breast cancer

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Abstract

Human estrogen sulfotransferase (SULT1E1) and nuclear factor erythroid 2-related factor 2 (Nrf-2) expression influences each other in advanced human breast carcinogenesis. The difference in the metabolism of estradiol (E2) in pre- and post-menopausal women remains to be connected with post-menopausal breast cancer. A synergism between ROS production and E2 generation has been demonstrated. No definite mechanism for simultaneous functions of Nrf2, oxidative stress E2 regulating enzymes (SULT1E1) has been yet clarified. Our present review demonstrates that ROS dependent regulation of Nrf-2 is one of the most important determinants of E2 regulation by altering SULT1E1 expression. This study also focuses the idea that estrogen receptor cased subtypes of cancer may have different molecular environments which has an impact on the therapeutic efficacy.

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Data availability

The datasets used and/or analysed during the current study available on request.

Abbreviations

SULT1E1:

Estrogen sulfotransferase

Nrf-2:

Nuclear factor erythroid 2-related factor 2

VAT:

Visceral adipose tissue

16αOHE1:

16α-Hydroxyestrone

STa:

Hydroxysteroid sulfotransferase

MTX:

Methotrexate

AST-IV:

Aryl sulfotransferase IV

MDA:

Malondialdehyde

NADPH:

Nicotinamide adenine dinucleotide phosphate hydrogen

MDA DG:

Deoxyguanosine malondialdehyde

MDA DA:

Deoxyadenosine malondialdehyde

ENU:

Ethyl nitroso urea

ARE:

Antioxidant response element

HO-1:

Heme oxygenase-1

GPX:

Glutathione peroxidase 1

NQO1:

NADPH dehydrogenase, quinone 1

GST:

Glutathionine S transferase

SOD:

Superoxide dismutase

Keap1:

Kelch-like ECH-associated protein 1

DLG:

Low-affinity binding site

LPS:

Lipopolysaccharides

CBP:

Cyclic-AMP response element binding protein

MafF:

Musculoaponeurotic fibrosarcoma homolog F

MafG:

Musculoaponeurotic fibrosarcoma homolog G

MafK:

Musculoaponeurotic fibrosarcoma homolog K

HNF4α:

Hepatocyte nuclear factor 4α

FXR:

Farnesoid X receptor

PXR:

Pregnane X receptor

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Acknowledgements

University Grants Commission, New Delhi provided JRF and SRF to AN who is a Ph.D. students working in the Post Graduate Department of Biochemistry, OIST.

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Institutional, no external funding.

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Authors and Affiliations

  1. Department of Biochemistry, Cell & Molecular Therapeutics Lab, Oriental Institute of Science & Technology, Midnapore, 721101, India

    Aarifa Nazmeen & Smarajit Maiti

  2. Oklahoma Technology & Research Park, Venture I OSU Laboratory, 1110 S. Innovation Way, Stillwater, OK, 74074, USA

    Guangping Chen

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  1. Aarifa Nazmeen
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Correspondence to Smarajit Maiti.

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Nazmeen, A., Chen, G. & Maiti, S. Dependence between estrogen sulfotransferase (SULT1E1) and nuclear transcription factor Nrf-2 regulations via oxidative stress in breast cancer. Mol Biol Rep 47, 4691–4698 (2020). https://doi.org/10.1007/s11033-020-05518-z

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