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Association of obesity and circulating adipose stromal cells among breast cancer survivors

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Abstract

A positive association of obesity with breast cancer incidence and mortality is well established. Recent reports indicate that adipose stromal cells (ASCs) play an important role in breast cancer development and progression by producing estrogens and tumor-promoting cytokines. Furthermore, circulating ASCs have been uniquely detected in obese individuals, which is likely due to increased tissue remodeling and cell mobilization. The number of circulating ASCs is even more prominent in obese patients with colon and prostate cancers, both of which are exacerbated by obesity. To determine whether a similar association exists for breast cancer, we collected blood samples from a cohort of breast cancer survivors and enumerated circulating ASCs by flow cytometry on the basis of the previously established ASC-associated immunophenotype (CD34+/CD31−/CD45−). We found significantly higher levels of circulating ASCs (p < 0.001) in breast cancer survivors with body mass index (BMI) ≥30 kg/m2 than their non-obese counterparts (BMI < 30). We also compared circulating ASCs before and after exercise of only the obese subjects enrolled in a 6-month individualized exercise program, but found no statistically significant difference, likely due to limited number of subjects in the study. Our findings suggest that circulating ASCs can serve as a potential biomarker for future studies of the impacts of obesity and physical activity on breast cancer recurrence and survival.

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References

  1. Nunez NP, Perkins SN, Smith NC et al (2008) Obesity accelerates mouse mammary tumor growth in the absence of ovarian hormones. Nutr Cancer 60:534–541

    Article  CAS  PubMed  Google Scholar 

  2. Baade PD, Fritschi L, Eakin EG (2006) Non-cancer mortality among people diagnosed with cancer (Australia). Cancer Causes Control 17:287–297

    Article  PubMed  Google Scholar 

  3. Demark-Wahnefried W, Pinto BM, Gritz ER (2006) Promoting health and physical function among cancer survivors: potential for prevention and questions that remain. J Clin Oncol 24:5125–5131

    Article  PubMed  Google Scholar 

  4. American Cancer Society (2012) Cancer treatment & survivorship facts & figures 2012–2013. American Cancer Society, Atlanta, p 44

    Google Scholar 

  5. McTiernan A (2003) Behavioral risk factors in breast cancer: can risk be modified? Oncologist 8:326–334

    Article  PubMed  Google Scholar 

  6. Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ (2003) Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 348:1625–1638

    Article  PubMed  Google Scholar 

  7. Bianchini F, Kaaks R, Vainio H (2002) Overweight, obesity, and cancer risk. Lancet Oncol 3:565–574

    Article  PubMed  Google Scholar 

  8. Petrelli JM, Calle EE, Rodriguez C, Thun MJ (2002) Body mass index, height, and postmenopausal breast cancer mortality in a prospective cohort of US women. Cancer Causes Control 13:325–332

    Article  PubMed  Google Scholar 

  9. Champ CE, Volek JS, Siglin J, Jin L, Simone NL (2012) Weight gain, metabolic syndrome, and breast cancer recurrence: are dietary recommendations supported by the data? Int J Breast Cancer 2012:506868

    Article  PubMed Central  PubMed  Google Scholar 

  10. Hampton T (2012) Breast cancer symposium highlights risk, recurrence, and research trials. JAMA 307:348–350

    Article  CAS  PubMed  Google Scholar 

  11. Ligibel J (2011) Obesity and breast cancer. Oncology (Williston Park) 25:994–1000

    Google Scholar 

  12. Protani M, Coory M, Martin JH (2010) Effect of obesity on survival of women with breast cancer: systematic review and meta-analysis. Breast Cancer Res Treat 123:627–635

    Article  PubMed  Google Scholar 

  13. Sparano JA, Wang M, Zhao F et al (2012) Obesity at diagnosis is associated with inferior outcomes in hormone receptor-positive operable breast cancer. Cancer 118:5937–5946

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  14. Ogden CL, Carroll MD, Kit BK, Flegal KM (2012) Prevalence of obesity in the United States, 2009–2010. NCHS Data Brief 1–8

  15. Speck RM, Courneya KS, Masse LC, Duval S, Schmitz KH (2010) An update of controlled physical activity trials in cancer survivors: a systematic review and meta-analysis. J Cancer Surviv 4:87–100

    Article  PubMed  Google Scholar 

  16. Speed-Andrews AE, Courneya KS (2009) Effects of exercise on quality of life and prognosis in cancer survivors. Curr Sports Med Rep 8:176–181

    Article  PubMed  Google Scholar 

  17. LaCroix AZ, Leveille SG, Hecht JA, Grothaus LC, Wagner EH (1996) Does walking decrease the risk of cardiovascular disease hospitalizations and death in older adults? J Am Geriatr Soc 44:113–120

    Article  CAS  PubMed  Google Scholar 

  18. Helmrich SP, Ragland DR, Leung RW, Paffenbarger RS Jr (1991) Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus. N Engl J Med 325:147–152

    Article  CAS  PubMed  Google Scholar 

  19. Giovannucci E, Ascherio A, Rimm EB, Colditz GA, Stampfer MJ, Willett WC (1995) Physical activity, obesity, and risk for colon cancer and adenoma in men. Ann Intern Med 122:327–334

    Article  CAS  PubMed  Google Scholar 

  20. Giovannucci EL, Liu Y, Leitzmann MF, Stampfer MJ, Willett WC (2005) A prospective study of physical activity and incident and fatal prostate cancer. Arch Intern Med 165:1005–1010

    Article  PubMed  Google Scholar 

  21. Neilson HK, Friedenreich CM, Brockton NT, Millikan RC (2009) Physical activity and postmenopausal breast cancer: proposed biologic mechanisms and areas for future research. Cancer Epidemiol Biomarkers Prev 18:11–27

    Article  CAS  PubMed  Google Scholar 

  22. Pate RR, Pratt M, Blair SN et al (1995) Physical activity and public health. A recommendation from the Centers for Disease Control and Prevention and the American College of Sports Medicine. JAMA 273:402–407

    Article  CAS  PubMed  Google Scholar 

  23. Blair SN, Cheng Y, Holder JS (2001) Is physical activity or physical fitness more important in defining health benefits? Med Sci Sports Exerc 33:S379–S399 discussion S419-320

    Article  CAS  PubMed  Google Scholar 

  24. Ainsworth BE, Sternfeld B, Slattery ML, Daguise V, Zahm SH (1998) Physical activity and breast cancer: evaluation of physical activity assessment methods. Cancer 83:611–620

    Article  CAS  PubMed  Google Scholar 

  25. Monninkhof EM, Elias SG, Vlems FA et al (2007) Physical activity and breast cancer: a systematic review. Epidemiology 18:137–157

    Article  PubMed  Google Scholar 

  26. Friedenreich CM, Cust AE (2008) Physical activity and breast cancer risk: impact of timing, type and dose of activity and population subgroup effects. Br J Sports Med 42:636–647

    Article  CAS  PubMed  Google Scholar 

  27. Warburton DE, Katzmarzyk PT, Rhodes RE, Shephard RJ (2007) Evidence-informed physical activity guidelines for Canadian adults. Can J Public Health 98(Suppl 2):S16–S68

    PubMed  Google Scholar 

  28. Doyle C, Kushi LH, Byers T et al (2006) Nutrition and physical activity during and after cancer treatment: an American Cancer Society guide for informed choices. CA Cancer J Clin 56:323–353

    Article  PubMed  Google Scholar 

  29. Schmitz KH, Holtzman J, Courneya KS, Masse LC, Duval S, Kane R (2005) Controlled physical activity trials in cancer survivors: a systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev 14:1588–1595

    Article  PubMed  Google Scholar 

  30. Courneya KS (2003) Exercise in cancer survivors: an overview of research. Med Sci Sports Exerc 35:1846–1852

    Article  PubMed  Google Scholar 

  31. Knols R, Aaronson NK, Uebelhart D, Fransen J, Aufdemkampe G (2005) Physical exercise in cancer patients during and after medical treatment: a systematic review of randomized and controlled clinical trials. J Clin Oncol 23:3830–3842

    Article  PubMed  Google Scholar 

  32. McTiernan A, Ulrich C, Slate S, Potter J (1998) Physical activity and cancer etiology: associations and mechanisms. Cancer Causes Control 9:487–509

    Article  CAS  PubMed  Google Scholar 

  33. Courneya KS, Mackey JR, Bell GJ, Jones LW, Field CJ, Fairey AS (2003) Randomized controlled trail of exercise training in postmenopausal breast cancer survivors: cardiopulmonary and quality of life outcomes. J Clin Oncol 21:1660–1668

    Article  PubMed  Google Scholar 

  34. Basen-Engquist K, Hughes D, Perkins H, Shinn E, Taylor CC (2008) Dimensions of physical activity and their relationship to physical and emotional symptoms in breast cancer survivors. J Cancer Surviv 2:253–261

    Article  PubMed Central  PubMed  Google Scholar 

  35. Hughes DC, Leung P, Naus MJ (2008) Using single-system analyses to assess the effectiveness of an exercise intervention on quality of life for Hispanic breast cancer survivors: a pilot study. Soc Work Health Care 47:73–91

    Article  PubMed  Google Scholar 

  36. Schmitz KH, Courneya KS, Matthews C et al (2010) American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Med Sci Sports Exerc 42:1409–1426

    Article  PubMed  Google Scholar 

  37. Segal R, Evans W, Johnson D et al (2001) Structured exercise improves physical functioning in women with stages I and II breast cancer: results of a randomized controlled trial. J Clin Oncol 19:657–665

    CAS  PubMed  Google Scholar 

  38. Segal RJ, Reid RD, Courneya KS et al (2003) Resistance exercise in men receiving androgen deprivation therapy for prostate cancer. J Clin Oncol 21:1653–1659

    Article  PubMed  Google Scholar 

  39. Pinto BM, Clark MM, Maruyama NC, Feder SI (2003) Psychological and fitness changes associated with exercise participation among women with breast cancer. Psychooncology 12:118–126

    Article  PubMed  Google Scholar 

  40. Lavie CJ, De Schutter A, Patel DA, Romero-Corral A, Artham SM, Milani RV (2012) Body composition and survival in stable coronary heart disease: impact of lean mass index and body fat in the “obesity paradox”. J Am Coll Cardiol 60:1374–1380

    Article  PubMed  Google Scholar 

  41. American College of Sports Medicine (2009) ACSM’s guidelines for exercise testing and prescription. Lippincott Williams & Wilkins, Philadelphia

    Google Scholar 

  42. Jackson AS, Moss RM (1997) Understanding exercise for health and fitness. Kendall/Hunt Publishing Company, Dubuque

    Google Scholar 

  43. Jackson AS, Ellis KJ, McFarlin BK, Sailors MH, Bray MS (2009) Cross-validation of generalised body composition equations with diverse young men and women: the Training Intervention and Genetics of Exercise Response (TIGER) Study. Br J Nutr 101:871–878

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  44. Demark-Wahnefried W (2007) Diet: energy balance and adiposity. In: American Society of Clinical Oncology (ed) ASCO curriculum: cancer prevention. American Society of Clinical Oncology, Alexandria, pp 3–33

    Google Scholar 

  45. Vona-Davis L, Howard-McNatt M, Rose DP (2007) Adiposity, type 2 diabetes and the metabolic syndrome in breast cancer. Obes Rev 8:395–408

    Article  CAS  PubMed  Google Scholar 

  46. Zhang Y, Daquinag A, Traktuev DO et al (2009) White adipose tissue cells are recruited by experimental tumors and promote cancer progression in mouse models. Cancer Res 69:5259–5266

    Article  CAS  PubMed  Google Scholar 

  47. Roberts DL, Dive C, Renehan AG (2010) Biological mechanisms linking obesity and cancer risk: new perspectives. Annu Rev Med 61:301–316

    Article  CAS  PubMed  Google Scholar 

  48. Khandekar MJ, Cohen P, Spiegelman BM (2011) Molecular mechanisms of cancer development in obesity. Nat Rev Cancer 11:886–895

    Article  CAS  PubMed  Google Scholar 

  49. Grossmann ME, Ray A, Nkhata KJ et al (2010) Obesity and breast cancer: status of leptin and adiponectin in pathological processes. Cancer Metastasis Rev 29:641–653

    Article  CAS  PubMed  Google Scholar 

  50. Ghosh S, Kang T, Wang H, Hu Y, Li R (2011) Mechanical phenotype is important for stromal aromatase expression. Steroids 76:797–801

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  51. Nichols JE, Bulun SE, Simpson ER (1995) Effects of conditioned medium from different cultured cell types on aromatase expression in adipose stromal cells. J Soc Gynecol Investig 2:45–50

    Article  CAS  PubMed  Google Scholar 

  52. Bulun SE, Chen D, Moy I, Brooks DC, Zhao H (2012) Aromatase, breast cancer and obesity: a complex interaction. Trends Endocrinol Metab 23:83–89

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  53. Reed MJ (1994) The role of aromatase in breast tumors. Breast Cancer Res Treat 30:7–17

    Article  CAS  PubMed  Google Scholar 

  54. Joe AW, Yi L, Even Y, Vogl AW, Rossi FM (2009) Depot-specific differences in adipogenic progenitor abundance and proliferative response to high-fat diet. Stem Cells 27:2563–2570

    Article  CAS  PubMed  Google Scholar 

  55. Maumus M, Sengenes C, Decaunes P et al (2008) Evidence of in situ proliferation of adult adipose tissue-derived progenitor cells: influence of fat mass microenvironment and growth. J Clin Endocrinol Metab 93:4098–4106

    Article  CAS  PubMed  Google Scholar 

  56. Daquinag AC, Zhang Y, Kolonin MG (2011) Vascular targeting of adipose tissue as an anti-obesity approach. Trends Pharmacol Sci 32:300–307

    Article  CAS  PubMed  Google Scholar 

  57. Chantrain CF, Feron O, Marbaix E, DeClerck YA (2008) Bone marrow microenvironment and tumor progression. Cancer Microenviron 1:23–35

    Article  PubMed Central  PubMed  Google Scholar 

  58. Galie M, Konstantinidou G, Peroni D et al (2008) Mesenchymal stem cells share molecular signature with mesenchymal tumor cells and favor early tumor growth in syngeneic mice. Oncogene 27:2542–2551

    Article  CAS  PubMed  Google Scholar 

  59. Karnoub AE, Dash AB, Vo AP et al (2007) Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 449:557–563

    Article  CAS  PubMed  Google Scholar 

  60. Bhowmick NA, Neilson EG, Moses HL (2004) Stromal fibroblasts in cancer initiation and progression. Nature 432:332–337

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  61. Ghosh S, Dean A, Walter M et al (2010) Cell density-dependent transcriptional activation of endocrine-related genes in human adipose tissue-derived stem cells. Exp Cell Res 316:2087–2098

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  62. Walter M, Liang S, Ghosh S, Hornsby PJ, Li R (2009) Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells. Oncogene 28:2745–2755

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  63. Blaber SP, Webster RA, Hill CJ et al (2012) Analysis of in vitro secretion profiles from adipose-derived cell populations. J Transl Med 10:172

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  64. Klopp AH, Zhang Y, Solley T et al (2012) Omental adipose tissue-derived stromal cells promote vascularization and growth of endometrial tumors. Clin Cancer Res 18:771–782

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  65. Muehlberg FL, Song YH, Krohn A et al (2009) Tissue-resident stem cells promote breast cancer growth and metastasis. Carcinogenesis 30:589–597

    Article  CAS  PubMed  Google Scholar 

  66. Prantl L, Muehlberg F, Navone NM et al (2010) Adipose tissue-derived stem cells promote prostate tumor growth. Prostate 70:1709–1715

    Article  CAS  PubMed  Google Scholar 

  67. Zimmerlin L, Donnenberg AD, Rubin JP, Basse P, Landreneau RJ, Donnenberg VS (2011) Regenerative therapy and cancer: in vitro and in vivo studies of the interaction between adipose-derived stem cells and breast cancer cells from clinical isolates. Tissue Eng Part A 17:93–106

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  68. Bellows CF, Zhang Y, Chen J, Frazier ML, Kolonin MG (2011) Circulation of progenitor cells in obese and lean colorectal cancer patients. Cancer Epidemiol Biomarkers Prev 20:2461–2468

    Article  CAS  PubMed  Google Scholar 

  69. Bellows CF, Zhang Y, Simmons PJ, Khalsa AS, Kolonin MG (2011) Influence of BMI on level of circulating progenitor cells. Obesity 19:1722–1726

    Article  PubMed Central  PubMed  Google Scholar 

  70. Ribeiro R, Monteiro C, Silvestre R et al (2012) Human periprostatic white adipose tissue is rich in stromal progenitor cells and a potential source of prostate tumor stroma. Exp Biol Med 237:1155–1162

    Article  CAS  Google Scholar 

  71. Cesari F, Sofi F, Gori AM et al (2012) Physical activity and circulating endothelial progenitor cells: an intervention study. Eur J Clin Invest 42:927–932

    Article  CAS  PubMed  Google Scholar 

  72. Kroepfl JM, Pekovits K, Stelzer I et al (2012) Exercise increases the frequency of circulating hematopoietic progenitor cells, but reduces hematopoietic colony-forming capacity. Stem Cells Dev 21:2915–2925

    Article  CAS  PubMed  Google Scholar 

  73. Ahmed RL, Thomas W, Yee D, Schmitz KH (2006) Randomized Controlled Trial of Weight Training and Lymphedema in Breast Cancer Survivors. J Clin Oncol 24:2765–2772

    Article  PubMed  Google Scholar 

  74. Schmitz KH (2010) Balancing lymphedema risk: exercise versus deconditioning for breast cancer survivors. Exerc Sport Sci Rev 38:17–24

    Article  PubMed Central  PubMed  Google Scholar 

  75. Schmitz KH, Ahmed RL, Troxel A et al (2009) Weight lifting in women with breast-cancer-related lymphedema. N Engl J Med 361:664–673

    Article  CAS  PubMed  Google Scholar 

  76. Schmitz KH, Ahmed RL, Troxel AB et al (2010) Weight lifting for women at risk for breast cancer-related lymphedema: a randomized trial. JAMA 304:2699–2705

    Article  CAS  PubMed  Google Scholar 

  77. Schmitz KH, Troxel AB, Cheville A et al (2009) Physical Activity and Lymphedema (the PAL trial): assessing the safety of progressive strength training in breast cancer survivors. Contemp Clin Trials 30:233–245

    Article  PubMed Central  PubMed  Google Scholar 

  78. Baumgartner TA, Jackson AS (1995) Measurement for evaluation in physical education and exercise science. Wm. C. Brown Communications Inc., Dubuque

    Google Scholar 

  79. Borg G (1998) Borg’s perceived exertion and pain scales. Human Kinetics, Champaign

    Google Scholar 

  80. Borg G (1982) Ratings of perceived exertion and heart rates during short-term cycle exercise and their use in a new cycling strength test. Int J Sports Med 3:153–158

    Article  CAS  PubMed  Google Scholar 

  81. Rikli RE, Jones CJ (1999) Development and validation of a functional fitness test for community-residing older adults. J Aging Phys Act 7:129–161

    Google Scholar 

  82. Duda DG, Cohen KS, Scadden DT, Jain RK (2007) A protocol for phenotypic detection and enumeration of circulating endothelial cells and circulating progenitor cells in human blood. Nat Protoc 2:805–810

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  83. Cuevas B, Hughes DC, Long Parma D, et al (2013) Motivation, exercise and stress in breast cancer survivors. Support Care Cancer (in press)

  84. Sazlina SG, Browning CJ, Yasin S (2012) Promoting physical activity in sedentary elderly Malays with type 2 diabetes: a protocol for randomised controlled trial. BMJ Open. doi:10.1136/bmjopen-2012-002119

    PubMed Central  PubMed  Google Scholar 

  85. Jane ML, Ho CC, Chen SC, Huang YC, Lai CH, Liaw YP (2012) A simple method for increasing high-density lipoprotein cholesterol levels: a pilot study of combination aerobic and resistance exercise training. Int J Sport Nutr Exerc Metab 2012 Nov 19. [Epub ahead of print]. http://www.ncbi.nlm.nih.gov/pubmed/23307435

  86. Davis CL, Pollock NK, Waller JL et al (2012) Exercise dose and diabetes risk in overweight and obese children: a randomized controlled trial. JAMA 308:1103–1112

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  87. Wang X, Sun Q, Mao F, Shen S, Huang L (2012) CTCs hemodialysis: can it be a new therapy for breast cancer? Med Hypotheses 80:99–101

    Article  CAS  PubMed  Google Scholar 

  88. Bidard FC, Fehm T, Ignatiadis M et al (2012) Clinical application of circulating tumor cells in breast cancer: overview of the current interventional trials. Cancer Metastasis Rev 32:179–188

    Article  PubMed Central  Google Scholar 

  89. Sinha G (2012) Circulating tumor cells in early-stage breast cancer. J Natl Cancer Inst 104:1693–1694

    Article  PubMed  Google Scholar 

  90. Zhang Y, Daquinag AC, Amaya-Manzanares F, Sirin O, Tseng C, Kolonin MG (2012) Stromal progenitor cells from endogenous adipose tissue contribute to pericytes and adipocytes that populate the tumor microenvironment. Cancer Res 72:5198–5208

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

This work was funded by Grants to Dr. Li from NIH (CA161349) and Cancer Prevention Research Institute of Texas (RP110524); to Dr. Ramirez from Susan G. Komen for the Cure (SAB08-00005); to Dr. Ghosh from San Antonio Area Foundation and ThriveWell Cancer Foundation; and to Dr. Hughes from the National Cancer Institute (K22 CA 154626, U54 CA153511). The content is solely the responsibility of the authors and does not necessarily represent the official views of the above-mentioned funding agencies. The authors gratefully acknowledge the support of the Cancer Therapy and Research Center at The University of Texas Health Science Center—San Antonio, an NCI-designated Cancer Center (P30CA054174). The authors also gratefully acknowledge the support of Dr. Amy Lang, the ThriveWell™ Cancer Foundation, and the START Center for Cancer Care.

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The authors declare to comply with all requirements for publication. There is no conflict of interest.

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Authors and Affiliations

  1. Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA

    Sagar Ghosh & Rong Li

  2. Department of Epidemiology & Biostatistics, Institute for Health Promotion Research, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA

    Daniel Hughes, Dorothy Long Parma & Amelie Ramirez

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  1. Sagar Ghosh
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  2. Daniel Hughes
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Correspondence to Rong Li.

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Ghosh, S., Hughes, D., Parma, D.L. et al. Association of obesity and circulating adipose stromal cells among breast cancer survivors. Mol Biol Rep 41, 2907–2916 (2014). https://doi.org/10.1007/s11033-014-3146-1

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