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Obesity and breast cancer: status of leptin and adiponectin in pathological processes

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Abstract

It is well recognized that obesity increases the risk of various cancers, including breast malignancies in postmenopausal women. Furthermore, obesity may adversely affect tumor progression, metastasis, and overall prognosis in both pre- and postmenopausal women with breast cancer. However, the precise mechanism(s) through which obesity acts is/are still elusive and this relationship has been the subject of much investigation and speculation. Recently, adipose tissue and its associated cytokine-like proteins, adipokines, particularly leptin and adiponectin, have been investigated as mediators for the association of obesity with breast cancer. Higher circulating levels of leptin found in obese subjects could be a growth-enhancing factor as supported by in vitro and preclinical studies, whereas low adiponectin levels in obese women may be permissive for leptin’s growth-promoting effects. These speculations are supported by in vitro studies which indicate that leptin promotes human breast cancer cell proliferation while adiponectin exhibits anti-proliferative actions. Further, estrogen and its receptors have a definite impact on the response of human breast cancer cell lines to leptin and adiponectin. More in-depth studies are needed to provide additional and precise links between the in vivo development of breast cancer and the balance of adiponectin and leptin.

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Acknowledgements

We are thankful to Dr. Joseph P. Grande of the Mayo Foundation, Rochester, Minnesota, for his pathological diagnosis of the tumors. We also thank The Breast Cancer Research Foundation, NCI grant CA101858 and the Hormel Foundation for the support.

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  1. The Hormel Institute, University of Minnesota, 801-16th Avenue NE, Austin, MN, 55912, USA

    Michael E. Grossmann, Amitabha Ray, Katai J. Nkhata, Dmitry A. Malakhov, Olga P. Rogozina, Soner Dogan & Margot P. Cleary

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  1. Michael E. Grossmann
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  2. Amitabha Ray
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Correspondence to Margot P. Cleary.

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Michael E. Grossmann and Amitabha Ray contributed equally to this review.

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Grossmann, M.E., Ray, A., Nkhata, K.J. et al. Obesity and breast cancer: status of leptin and adiponectin in pathological processes. Cancer Metastasis Rev 29, 641–653 (2010). https://doi.org/10.1007/s10555-010-9252-1

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