Abstract
The P5CS ({Delta} 1-Pyrroline–5-Carboxylate Synthetase) gene encodes for a bifunctional enzyme that catalyzes the rate limiting reaction in proline biosynthesis in living organisms. A wide range of multifunctional roles of proline have now been shown in stress defense. The proline biosynthetic genes, especially, P5CS is commonly used in metabolic engineering for proline overproduction conferring stress tolerance in plants. The gene is functionally well characterized at the molecular level, but there is more to learn about its evolutionary path in the plant kingdom, particularly the drive behind functional (osmoprotective and developmental) divergence of duplication of P5CS genes. In this review, we present the current understanding of the evolutionary trail of plant P5CS gene which plays a key role in stress tolerance.
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Rai, A.N., Penna, S. Molecular evolution of plant P5CS gene involved in proline biosynthesis. Mol Biol Rep 40, 6429–6435 (2013). https://doi.org/10.1007/s11033-013-2757-2
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DOI: https://doi.org/10.1007/s11033-013-2757-2