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Association between CYP1A1 polymorphisms and esophageal cancer: a meta-analysis

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Abstract

Cytochrome P4501A1 (CYP1A1) enzyme is a member of the CYP superfamily of enzymes. CYP1A1 A2455G and T3801C are two most commonly studied polymorphisms loci. Previous studies have reported that CYP1A1 polymorphisms increase esophageal cancer (EC) risk. However, the results remain controversial and ambiguous. To further investigate the association between CYP1A1 polymorphisms (A2455G and T3801C) and EC risk. A meta-analysis was performed to investigate the association between CYP1A1 polymorphisms and EC risk. A total of 13 articles (A2455G and T3801C: 2 papers, A2455G: 8 papers, T3801C: 3 papers) from the PubMed containing information on the CYP1A1 polymorphisms and EC were included in this meta-analysis, with summational sample size of 1,881 EC cases and 3,786 controls. Stratified analysis was performed to evaluate the ethnicity (Caucasians and Asian) and histopathology type (esophageal squamous cell carcinoma and esophageal adenocarcinoma) effect. No obvious publication bias in the two polymorphisms was observed. Our meta-analysis revealed a significant association between the A2455G polymorphism and EC (OR = 1.55 per A allele, 95 % CI 1.29–1.85, P < 0.001). Stratification analysis by ethnicity and histopathology type showed significant association in the population of Asian origin (OR = 1.55, 95 % CI 1.28–1.89, P < 0.001) and in histopathology type of ESCC (OR = 1.40, 95 % CI 1.19–1.65, P < 0.001). We didn’t observe the significant association between CYP1A1 T3801C polymorphism and EC. We observed a difference of allele frequencies between Caucasian and Asian population in the meta-analysis. The allele frequencies in our meta-analysis were consistent with the allele frequencies in 1000 Genome Project. Our meta-analysis demonstrated distinct evidence that CYP1A1 A2455G polymorphism was associated with the risk of EC.

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References

  1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J Clin 61:69–90

    Article  PubMed  Google Scholar 

  2. Guo W, Jiang YG (2009) Current gene expression studies in esophageal carcinoma. Curr Genomics 10:534–539

    Article  PubMed  CAS  Google Scholar 

  3. Daly JM, Fry WA, Little AG, Winchester DP, McKee RF, Stewart AK et al (2000) Esophageal cancer: results of an American College of Surgeons Patient Care Evaluation Study. J Am Coll Surg 190:562–572 discussion 563–572

    Article  PubMed  CAS  Google Scholar 

  4. Engel LS, Chow WH, Vaughan TL, Gammon MD, Risch HA, Stanford JL et al (2003) Population attributable risks of esophageal and gastric cancers. J Natl Cancer Inst 95:1404–1413

    Article  PubMed  Google Scholar 

  5. Morita M, Kumashiro R, Kubo N, Nakashima Y, Yoshida R, Yoshinaga K et al (2010) Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus: epidemiology, clinical findings, and prevention. Int J Clin Oncol 15:126–134

    Article  PubMed  Google Scholar 

  6. Messmann H (2001) Squamous cell cancer of the oesophagus. Best Pract Res Clin Gastroenterol 15:249–265

    Article  PubMed  CAS  Google Scholar 

  7. Tran GD, Sun XD, Abnet CC, Fan JH, Dawsey SM, Dong ZW et al (2005) Prospective study of risk factors for esophageal and gastric cancers in the Linxian general population trial cohort in China. Int J Cancer 113:456–463

    Article  PubMed  CAS  Google Scholar 

  8. Hongo M, Nagasaki Y, Shoji T (2009) Epidemiology of esophageal cancer: orient to occident. Effects of chronology, geography and ethnicity. J Gastroenterol Hepatol 24:729–735

    Article  PubMed  Google Scholar 

  9. Cheung WY, Liu G (2009) Genetic variations in esophageal cancer risk and prognosis. Gastroenterol Clin North Am 38:75–91

    Article  PubMed  Google Scholar 

  10. Agundez JA (2004) Cytochrome P450 gene polymorphism and cancer. Curr Drug Metab 5:211–224

    Article  PubMed  CAS  Google Scholar 

  11. Cascorbi I, Brockmoller J, Roots I (1996) A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility. Cancer Res 56:4965–4969

    PubMed  CAS  Google Scholar 

  12. Hayashi S, Watanabe J, Nakachi K, Kawajiri K (1991) Genetic linkage of lung cancer-associated MspI polymorphisms with amino acid replacement in the heme binding region of the human cytochrome P450IA1 gene. J Biochem 110:407–411

    PubMed  CAS  Google Scholar 

  13. Kawajiri K, Nakachi K, Imai K, Yoshii A, Shinoda N, Watanabe J (1990) Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P450IA1 gene. FEBS Lett 263:131–133

    Article  PubMed  CAS  Google Scholar 

  14. Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327:557–560

    Article  PubMed  Google Scholar 

  15. Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629–634

    Article  PubMed  CAS  Google Scholar 

  16. Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50:1088–1101

    Article  PubMed  CAS  Google Scholar 

  17. Malik MA, Upadhyay R, Mittal RD, Zargar SA, Mittal B (2010) Association of xenobiotic metabolizing enzymes genetic polymorphisms with esophageal cancer in Kashmir Valley and influence of environmental factors. Nutr Cancer 62:734–742

    Article  PubMed  CAS  Google Scholar 

  18. Jain M, Kumar S, Ghoshal UC, Mittal B (2007) CYP1A1 Msp1 T/C polymorphism in esophageal cancer: no association and risk modulation. Oncol Res 16:437–443

    PubMed  CAS  Google Scholar 

  19. Casson AG, Zheng Z, Chiasson D, MacDonald K, Riddell DC, Guernsey JR et al (2003) Associations between genetic polymorphisms of phase I and II metabolizing enzymes, p53 and susceptibility to esophageal adenocarcinoma. Cancer Detect Prev 27:139–146

    Article  PubMed  CAS  Google Scholar 

  20. van Lieshout EM, Roelofs HM, Dekker S, Mulder CJ, Wobbes T, Jansen JB et al (1999) Polymorphic expression of the glutathione S-transferase P1 gene and its susceptibility to Barrett’s esophagus and esophageal carcinoma. Cancer Res 59:586–589

    PubMed  Google Scholar 

  21. Hori H, Kawano T, Endo M, Yuasa Y (1997) Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and human esophageal squamous cell carcinoma susceptibility. J Clin Gastroenterol 25:568–575

    Article  PubMed  CAS  Google Scholar 

  22. Wang D, Su M, Tian D, Liang S, Zhang J (2012) Associations between CYP1A1 and CYP2E1 polymorphisms and susceptibility to esophageal cancer in Chaoshan and Taihang areas of China. Cancer Epidemiol 36:276–282

    Article  PubMed  CAS  Google Scholar 

  23. Wideroff L, Vaughan TL, Farin FM, Gammon MD, Risch H, Stanford JL et al (2007) GST, NAT1, CYP1A1 polymorphisms and risk of esophageal and gastric adenocarcinomas. Cancer Detect Prev 31:233–236

    Article  PubMed  CAS  Google Scholar 

  24. Abbas A, Delvinquiere K, Lechevrel M, Lebailly P, Gauduchon P, Launoy G et al (2004) GSTM1, GSTT1, GSTP1 and CYP1A1 genetic polymorphisms and susceptibility to esophageal cancer in a French population: different pattern of squamous cell carcinoma and adenocarcinoma. World J Gastroenterol 10:3389–3393

    PubMed  CAS  Google Scholar 

  25. Wang AH, Sun CS, Li LS, Huang JY, Chen QS (2002) Relationship of tobacco smoking CYP1A1 GSTM1 gene polymorphism and esophageal cancer in Xi’an. World J Gastroenterol 8:49–53

    PubMed  CAS  Google Scholar 

  26. Shao G, Su Y, Huang G, Wen B (2000) Relationship between CYP1A1, GSTM1 genetic polymorphisms and susceptibility to esophageal squamous cell carcinoma. Zhonghua Liu Xing Bing Xue Za Zhi 21:420–423

    PubMed  CAS  Google Scholar 

  27. Zhang H, Sun C, Li L, Yan M (2000) Cytochrome P450IA1 and the genetic susceptibility to esophageal carcinoma. Zhonghua Yu Fang Yi Xue Za Zhi 34:69–71

    PubMed  CAS  Google Scholar 

  28. Morita S, Yano M, Shiozaki H, Tsujinaka T, Ebisui C, Morimoto T et al (1997) CYP1A1, CYP2E1 and GSTM1 polymorphisms are not associated with susceptibility to squamous-cell carcinoma of the esophagus. Int J Cancer 71:192–195

    Article  PubMed  CAS  Google Scholar 

  29. Nimura Y, Yokoyama S, Fujimori M, Aoki T, Adachi W, Nasu T et al (1997) Genotyping of the CYP1A1 and GSTM1 genes in esophageal carcinoma patients with special reference to smoking. Cancer 80:852–857

    Article  PubMed  CAS  Google Scholar 

  30. Wang AH, Sun CS, Li LS, Huang JY, Chen QS, Xu DZ (2004) Genetic susceptibility and environmental factors of esophageal cancer in Xi’an. World J Gastroenterol 10:940–944

    PubMed  Google Scholar 

  31. Wang Z, Tang L, Sun G, Tang Y, Xie Y, Wang S et al (2006) Etiological study of esophageal squamous cell carcinoma in an endemic region: a population-based case control study in Huaian, China. BMC Cancer 6:287

    Article  PubMed  Google Scholar 

  32. Sepehr A, Kamangar F, Abnet CC, Fahimi S, Pourshams A, Poustchi H et al (2004) Genetic polymorphisms in three Iranian populations with different risks of esophageal cancer, an ecologic comparison. Cancer Lett 213:195–202

    Article  PubMed  CAS  Google Scholar 

  33. Layke JC, Lopez PP (2006) Esophageal cancer: a review and update. Am Fam Phys 73:2187–2194

    Google Scholar 

  34. Wu C, Kraft P, Zhai K, Chang J, Wang Z, Li Y et al (2012) Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. Nat Genet 44:1090–1097

    Article  PubMed  CAS  Google Scholar 

  35. Umar SB, Fleischer DE (2008) Esophageal cancer: epidemiology, pathogenesis and prevention. Nat Clin Pract Gastroenterol Hepatol 5:517–526

    Google Scholar 

  36. Wu C, Hu Z, He Z, Jia W, Wang F, Zhou Y et al (2011) Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. Nat Genet 43:679–684

    Article  PubMed  CAS  Google Scholar 

  37. Wang LD, Zhou FY, Li XM, Sun LD, Song X, Jin Y et al (2010) Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. Nat Genet 42:759–763

    Article  PubMed  CAS  Google Scholar 

  38. Abnet CC, Freedman ND, Hu N, Wang Z, Yu K, Shu XO et al (2010) A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. Nat Genet 42:764–767

    Article  PubMed  CAS  Google Scholar 

  39. Bartsch H, Nair U, Risch A, Rojas M, Wikman H, Alexandrov K (2000) Genetic polymorphism of CYP genes, alone or in combination, as a risk modifier of tobacco-related cancers. Cancer Epidemiol Biomarkers Prev 9:3–28

    PubMed  CAS  Google Scholar 

  40. Lechevrel M, Casson AG, Wolf CR, Hardie LJ, Flinterman MB, Montesano R et al (1999) Characterization of cytochrome P450 expression in human oesophageal mucosa. Carcinogenesis 20:243–248

    Article  PubMed  CAS  Google Scholar 

  41. Chen C, Huang Y, Li Y, Mao Y, Xie Y (2007) Cytochrome P450 1A1 (CYP1A1) T3801C and A2455G polymorphisms in breast cancer risk: a meta-analysis. J Hum Genet 52:423–435

    Article  PubMed  CAS  Google Scholar 

  42. Landi MT, Bertazzi PA, Shields PG, Clark G, Lucier GW, Garte SJ et al (1994) Association between CYP1A1 genotype, mRNA expression and enzymatic activity in humans. Pharmacogenetics 4:242–246

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

Dr. Hou-Feng Zheng is supported by the Canadian Institutes of Health Research (CIHR). We thank Dr. Wan-Cai Yang from the School of Basal Medical Sciences, Xinxiang Medical University, Xinxiang, Henan, China, for carefully reading of this manuscript.

Conflict of interest

None.

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Authors and Affiliations

  1. The Key Laboratory for Tumor Translational Medicine, The Third Affiliated Hospital, Xinxiang Medical University, Xinxiang, Henan, China

    Fang-Fang Shen, Ying Pan & Hua Zhang

  2. Department of Thoracic Surgery, Anyang Tumor Hospital, Anyang, Henan, China

    Fu-You Zhou

  3. Intensive Care Unit, Royal Victoria Hospital, Montreal, H3A 1A1, Quebec, Canada

    Qi-Si Xue

  4. Fuzhou Medical College, Nanchang University, Nanchang, China

    Lu Zheng

  5. Henan Key Laboratory for Esophageal Cancer Research, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China

    Li-Dong Wang

  6. Department of Medicine and Human Genetics, McGill University, Montreal, H3A 0G4, QC, Canada

    Hou-Feng Zheng

  7. Department of Epidemiology and Biostatistics, Lady Davis Institute, Jewish General Hospital, Montreal, H3T 1E2, QC, Canada

    Hou-Feng Zheng

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  1. Fang-Fang Shen
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Correspondence to Hou-Feng Zheng.

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Fang-Fang Shen, Fu-You Zhou, and Qi-Si Xue contributed equally to this work.

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Shen, FF., Zhou, FY., Xue, QS. et al. Association between CYP1A1 polymorphisms and esophageal cancer: a meta-analysis. Mol Biol Rep 40, 6035–6042 (2013). https://doi.org/10.1007/s11033-013-2713-1

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  • DOI: https://doi.org/10.1007/s11033-013-2713-1

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