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Genetic variation of the CYP17 and susceptibility to endometrial cancer: a meta-analysis

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Abstract

Excessive estrogenic influence is known to be associated with initiation/promotion of endometrial cancer (EC). Common variants among genes coding for enzymes in sex steroid biosynthetic pathways may influence the risk of EC. Cytochrome P450c17α (CYP17), a gene that codes for a key enzyme (cytochrome P450c17α) in a rate-limiting step of estrogen biosynthesis has attracted considerable attention as a candidate gene for EC. The relationship between CYP17 and EC has been reported in various ethnic groups; however, these studies have yielded contradictory results. To investigate this inconsistency, we performed a meta-analysis of 13 studies involving a total of 3,258 cases and 4,614 controls for −34T>C (rs743572) polymorphism of the CYP17 gene to evaluate the effect of CYP17 on genetic susceptibility for EC. An overall random effects odds ratio of 0.71 (95 % confidence interval 0.58–0.88, P = 0.001) was found under recessive genetic model. Stratified analysis based on ethnicity, sample size and Hardy–Weinberg equilibrium status was conducted to explore potential heterogeneity. This meta-analysis demonstrated that the C allele of −34T>C in CYP17 is a protective factor associated with decreased EC susceptibility, but these associations vary in different ethnic populations.

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Authors and Affiliations

  1. Department of Gynaecology and Obstetrics, Shanghai Minhang District Center Hospital, 285 Xindong Road, Shanghai, 201100, People’s Republic of China

    Jun Xu, Xiao Lin, Haoping Zhu, Zhiling Zhang & Baohua Yang

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  1. Jun Xu
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  2. Xiao Lin
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  3. Haoping Zhu
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  4. Zhiling Zhang
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  5. Baohua Yang
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Correspondence to Jun Xu.

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Xu, J., Lin, X., Zhu, H. et al. Genetic variation of the CYP17 and susceptibility to endometrial cancer: a meta-analysis. Mol Biol Rep 40, 5085–5091 (2013). https://doi.org/10.1007/s11033-013-2609-0

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  • DOI: https://doi.org/10.1007/s11033-013-2609-0

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