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Variants in hormone biosynthesis genes and risk of endometrial cancer

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Abstract

We investigated the risk associated with variants in three genes involved in estrogen biosynthesis, CYP11A1, CYP17A1, and CYP19A1, in the population-based case–control study of Estrogen, Diet, Genetics, and Endometrial Cancer. This study was conducted in New Jersey in 2001–2006 with 417 cases and 402 controls. For CYP11A1, there was no association between the number of [TTTTA] n repeats (D15S520) and risk. For CYP17A1, risk was somewhat lower among women with the C/C genotype at T-34C (rs743572) (adjusted OR = 0.65, 95% CI 0.41–1.02). For CYP19A1, risk was lower among women homozygous for the 3-bp deletion (rs11575899) in exon 4 (adjusted OR = 0.44, 95% CI 0.26–0.76), while the number of [TTTA] n repeats was not significantly related to risk: the adjusted OR for n = 7/7 repeats versus n > 7/>7 repeats was 0.81 (95% CI 0.54–1.23). In stratified analyses, results for CYP19A1 were stronger among women with higher (≥27.4) body mass index: for the homozygous deletion, OR = 0.30 (95% CI 0.15–0.62); for the n = 7/7 genotype, OR = 0.49 (95% CI 0.26–0.93). The interaction between the n = 7/7 genotype and BMI was statistically significant (p = 0.01). The insertion/deletion variant in CYP19A1 appears to be related to risk of endometrial cancer; risk associated with variants in this gene may vary according to BMI.

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Acknowledgments

We thank the interviewers, students, and staff who worked on this study: Silvia Brendel, Nora Geraghty, Dina Gifkins, June Kittredge, Sharon Lojun, Elinor Miller, Louise Salant, Mathilde Saxon, Michelle Sriprasert, Elizabeth Ward, Doreen Wass, Melony Williams, Kay Yoon; and New Jersey Department of Health and Senior Services personnel Tara Blando, Stacey Izzard, Joan Kay, Betsy Kohler, Kevin Masterson, Helen Weiss. Financial support: National Cancer Institute grants R01CA83918 (S. Olson) and K07CA095666 (E. Bandera).

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Authors and Affiliations

  1. Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, 307 East 63 Street, New York, NY, 10065, USA

    Sara H. Olson, Irene Orlow, Sharon Bayuga, Camelia Sima, Diana Tommasi, Pampa Roy & Ann G. Zauber

  2. Cancer Institute of New Jersey, New Brunswick, NJ, USA

    Elisa V. Bandera

  3. William Randolph Hearst Burn Center, New York Presbyterian Hospital, 525 East 68th Street, New York, NY, 10021, USA

    Katherine Pulick

  4. Glencoe/McGraw-Hill, 21600 Oxnard Street, Woodland Hills, CA, 91367, USA

    Shameka Faulkner

  5. Department of Medecine, NYU Medical Center, 550 First Avenue, New York, NY, 10016, USA

    Daniel Egan

  6. New Jersey Department of Health and Senior Services, Trenton, NJ, USA

    Homer Wilcox

  7. Department of Pathology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10021, USA

    Ali Asya, Ippolito Modica & Robert Soslow

  8. Department of Pathology, Memorial Sloan-Kettering Cancer Center, 307 East 63 Street, New York, NY, 10065, USA

    Haider Asad

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  1. Sara H. Olson
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  12. Ali Asya
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  16. Ann G. Zauber
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Correspondence to Sara H. Olson.

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Olson, S.H., Orlow, I., Bayuga, S. et al. Variants in hormone biosynthesis genes and risk of endometrial cancer. Cancer Causes Control 19, 955–963 (2008). https://doi.org/10.1007/s10552-008-9160-7

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  • DOI: https://doi.org/10.1007/s10552-008-9160-7

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