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Intercellular adhesion molecule 1 gene K469E polymorphism is associated with coronary heart disease risk: a meta-analysis involving 12 studies

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Abstract

Coronary atherosclerosis is a leading cause of coronary heart disease (CHD). Atherosclerotic lesion is a complex polygenic disease in which gene-environment interactions play a critical role in disease onset and progression. The ICAM1 gene-E469K polymorphism has been reported to be associated with CHD, but results were conflicting. A systematic review and meta-analysis of the published studies were performed to gain a clearer understanding of this association. The PubMed, Embase, and CNKI databases were searched for case–control studies published up to August 2011. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. Twelve eligible studies, comprising 2,157 cases and 1,952 controls, were included in the meta-analysis. The pooled result showed that the ICAM1 gene-E469K polymorphism was significantly associated with an increased risk of CHD (OR = 1.496, 95% CI = 1.363–1.642, for the allele K vs. allele E; OR = 1.919, 95% CI = 11.635–2.253, for the K allele carriers vs. EE). Subgroup analysis supported the results in the Asian populations and in the Caucasian populations. This meta-analysis suggests that the ICAM1 gene K469E polymorphism is associated with CHD risk and the K allele is a more significant risk factor for developing CHD among Asian and Caucasians populations.

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References

  1. Ross R (1999) Atherosclerosis—an inflammatory disease. N Engl J Med 340:115–126

    Article  PubMed  CAS  Google Scholar 

  2. Blankenberg S, Barbaux S, Tiret L (2003) Adhesion molecules and atherosclerosis. Atherosclerosis 170:191–203

    Article  PubMed  CAS  Google Scholar 

  3. Hayflick JS, Kilgannon P, Gallatin WM (1998) The intercellular adhesion molecule (ICAM) family of proteins. New members and novel functions. Immunol Res 17:313–327

    Article  PubMed  CAS  Google Scholar 

  4. Gaetani E, Flex A, Pola R, Papaleo P, De Martini D, Pola E, Aloi F, Flore R, Serricchio M, Gasbarrini A, Pola P (2002) The K469E polymorphism of the ICAM-1 gene is a risk factor for peripheral arterial occlusive disease. Blood Coagul Fibrinolysis 13:483–488

    Article  PubMed  CAS  Google Scholar 

  5. Iwao M, Morisaki H, Morisaki T (2004) Single-nucleotide polymorphism g.1548 G > A (E469K) in human ICAM-1 gene affects mRNA splicing pattern and TPA-induced apoptosis. Biochem Biophys Res Commun 317:729–735

    Article  PubMed  CAS  Google Scholar 

  6. Cochran WG (1954) The combination of estimates from different experiments. Biometrics 10:101–129

    Article  Google Scholar 

  7. Mantel N, Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22:719–748

    PubMed  CAS  Google Scholar 

  8. DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177–188

    Article  PubMed  CAS  Google Scholar 

  9. Tobias A (1999) Assessing the influence of a single study in the meta-analysis estimate. Stata Tech Bull 8:15–17

    Google Scholar 

  10. Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in metaanalysis detected by a simple, graphical test. BMJ 315:629–634

    Article  PubMed  CAS  Google Scholar 

  11. Li YJ, Han M, Zheng B et al (2010) The relationship between K469E polymorphism of the intercellular adhesion molecule-1 gene and coronary heart disease [in chinese]. Chin J Gerontol 23:3494–3495

    Google Scholar 

  12. Lu FH, Shan Q, Wen P et al (2006) A study on K469E polymorphismof ICAM1 and ICAM1 plasma level in patient s with coronary heart disease [in chinese]. Chin J Med Genet 23:195–197

    CAS  Google Scholar 

  13. Rao D, Jiang H, Zeng QT et al (2005) The study of intercellular adhesion molecule-1 gene polymorphisms C469T in patients with coronary heart disease [in chinese]. J Clin Cardiol(China) 21:648–650

    Google Scholar 

  14. Shan Q, Lu FH, Wen P et al (2005) The study of intercellular adhesion molecule-1 gene polymorphisms C469T in the elderly with coronary heart disease [in chinese]. Chin J Geriatr 24:444–445

    Google Scholar 

  15. Wang M, Li Y, Zhang PA, Yang C, Xiang PX, Wei YS, Li XY, Huang CX (2005) Study on the intercellular molecule-1 polymorphisms in an Chinese population with myocardial infarction [in chinese]. Chin J Epidemiol 26:702–706

    Google Scholar 

  16. Wei YS, Tang RG, Yuan XH et al (2006) Association between polymorphism of intercellular adhesion molecule-1 gene K469E and coronary heart disease[in chinese]. Chin J Immunol 22:1056–1059

    CAS  Google Scholar 

  17. Zhang SR, Xu LX, Gao QQ, Zhang HQ, Xu BS, Lin J, Huang WJ (2006) The correlation between ICAM-1 gene K469E polymorphism and coronary heart disease [in chinese]. Chin J Med Gene 23:205–207

    Google Scholar 

  18. Zhou YL, Zhu MA, Ding Y et al (2006) Association between intercellular adhesion molecule-1 gene polymorphism and coronary heart disease [in chinese]. J Clin Cardiol 22:519–522

    Google Scholar 

  19. Milutinović A, Petrovic D (2006) The K469E polymorphism of the intracellular adhesion molecule 1 (ICAM-1) gene is not associated with myocardial infarction in Caucasians with type 2 diabetes. Folia Biol (Praha) 52:79–80

    Google Scholar 

  20. Jiang H, Klein RM, Niederacher D, Du M, Marx R, Horlitz M, Boerrigter G, Lapp H, Scheffold T, Krakau I, Gülker H (2002) C/T polymorphism of the intercellular adhesion molecule-1 gene (exon 6, codon 469). A risk factor for coronary heart disease and myocardial infarction. Int J Cardiol 84:171–177

    Article  PubMed  Google Scholar 

  21. Mohamed AA, Rashed L, Amin H, Abu-Farha M, El Fadl SA, Pakhoum S (2010) K469E polymorphism of the intercellular adhesion molecule-1 gene in Egyptians with coronary heart disease. Ann Saudi Med 30:432–436

    PubMed  Google Scholar 

  22. Sarecka-Hujar B, Zak I, Krauze J (2009) Interactions between rs5498 polymorphism in the ICAM1 gene and traditional risk factors influence susceptibility to coronary artery disease. Clin Exp Med 9:117–124

    Article  PubMed  CAS  Google Scholar 

  23. Sarecka-Hujar B, Zak I, Krauze J (2008) Carrier-state of two or three polymorphic variants of MTHFR, IL-6 and ICAM1 genes increases the risk of coronary artery disease. Kardiol Pol 66:1269–1277

    PubMed  Google Scholar 

  24. Kitagawa K, Matsumoto M, Sasaki T, Hashimoto H, Kuwabara K, Ohtsuki T, Hori M (2002) Involvement of ICAM-1 in the progression of atherosclerosis in APOE-knockout mice. Atherosclerosis 160:305–310

    Article  PubMed  CAS  Google Scholar 

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Conflict of interest

The authors declare no conflicts of interest in this research.

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Authors and Affiliations

  1. Jiangsu Province Hospital of Traditional Chinese Medicine, 155 Hanzhong Road, Nanjing, 210029, China

    Ya-Nan Ji

  2. Department of Respiratory Medicine, No. 81 Hospital of PLA, Nanjing, China

    Qin Wang

  3. First Department of Respiratory Medicine, Nanjing Chest Hospital, 215 Guangzhou Road, Nanjing, 210029, China

    Ping Zhan

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  1. Ya-Nan Ji
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  2. Qin Wang
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  3. Ping Zhan
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Correspondence to Ping Zhan.

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Ya-Nan Ji and Qin Wang contributed equally to this work and should be considered as co-first authors.

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Ji, YN., Wang, Q. & Zhan, P. Intercellular adhesion molecule 1 gene K469E polymorphism is associated with coronary heart disease risk: a meta-analysis involving 12 studies. Mol Biol Rep 39, 6043–6048 (2012). https://doi.org/10.1007/s11033-011-1418-6

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  • DOI: https://doi.org/10.1007/s11033-011-1418-6

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