Skip to main content

Advertisement

SpringerLink
Log in

−251 T/A polymorphism of the interleukin-8 gene and cancer risk: a HuGE review and meta-analysis based on 42 case–control studies

  • Published:
Molecular Biology Reports Aims and scope Submit manuscript

Abstract

The −251T/A (rs4073), a single nucleotide polymorphism, has been identified in the promoter region of the interleukin-8 (IL-8) gene. It’s presence could influence the production of IL-8 protein by regulating the transcriptional activity of the gene. A large number of studies have been performed to evaluate the role of −251T/A polymorphism on various cancers, with inconsistent results being reported. In this paper, we summarized 13,189 cases and 16,828 controls from 42 case–control studies and attempted to assess the susceptibility of −251T/A polymorphism to cancers by a comprehensive meta-analysis. Pooled odds ratios and 95% confidence intervals were calculated by using the random-effects model. Publication bias, subgroup, and sensitivity analysis were also performed. Results showed that the carriers of the −251A allele had about a 12–21% increased risk for the reviewed cancer, in total. The carriers of −251A had an elevated risk to breast cancer, gastric cancer and nasopharyngeal cancer and a reduced risk to prostate cancer, but no evidence was found to indicate that the −251A allele predisposed its carriers to colorectal and lung cancers. When stratified separately by ‘racial descent’ and ‘study design’, it was found that the carriers of the −251A allele among the African group, Asian group and hospital-based case–control study group were at a higher risk for cancer, but not in European group and population-based case–control study. These results show that −251A allele is susceptible in the development of low-penetrance cancers.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Brat DJ, Bellail AC, Van Meir EG (2005) The role of interleukin-8, its receptors in gliomagenesis, tumoral angiogenesis. Neuro-Oncology 7(2):122–133

    Article  PubMed  CAS  Google Scholar 

  2. Balkwill F (2004) Cancer and the chemokine network. Nat Rev Cancer 4(7):540–550

    Article  PubMed  CAS  Google Scholar 

  3. Vicari AP, Caux C (2002) Chemokines in cancer. Cytokine Growth Factor Rev 13(2):143–154

    Article  PubMed  CAS  Google Scholar 

  4. Harada A, Sekido N, Akahoshi T et al (1994) Essential involvement of interleukin-8 (IL-8) in acute inflammation. J Leukoc Biol 56(5):559–564

    PubMed  CAS  Google Scholar 

  5. Xie K (2001) Interleukin-8, human cancer biology. Cytokine Growth Factor Rev 12(4):375–391

    Article  PubMed  CAS  Google Scholar 

  6. Rollins BJ (1997) Chemokines. Blood 90(3):909–928

    PubMed  CAS  Google Scholar 

  7. Du H, Bay BH, Mahendran R et al (2002) Endogenous expression of interleukin-8, interleukin-10 in nasopharyngeal carcinoma cells, the effect of photodynamic therapy. Int J Mol Med 10(1):73–76

    PubMed  CAS  Google Scholar 

  8. Heinzmann A, Ahlert I, Kurz T et al (2004) Association study suggests opposite effects of polymorphisms within IL8 on bronchial asthma, respiratory syncytial virus bronchiolitis. J Allergy Clin Immunol 114(3):671–676

    Article  PubMed  CAS  Google Scholar 

  9. van Aken BE, Reitsma PH, Rosendaal FR (2002) Interleukin 8, venous thrombosis: evidence for a role of inflammation in thrombosis. Br J Haematol 116(1):173–177

    Article  PubMed  Google Scholar 

  10. Koch AE, Polverini PJ, Kunkel SL et al (1992) Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science 258(5089):1798–1801

    Article  PubMed  CAS  Google Scholar 

  11. Kitadai Y, Haruma K, Mukaida N et al (2000) Regulation of disease-progression genes in human gastric carcinoma cells by interleukin 8. Clin Cancer Res 6(7):2735–2740

    PubMed  CAS  Google Scholar 

  12. Bendre MS, Gaddy-Kurten D, Mon-Foote T et al (2002) Expression of interleukin 8 and not parathyroid hormone-related protein by human breast cancer cells correlates with bone metastasis in vivo. Cancer Res 62(19):5571–5579

    PubMed  CAS  Google Scholar 

  13. Li A, Dubey S, Varney ML et al (2003) IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis. J Immunol 170(6):3369–3376

    PubMed  CAS  Google Scholar 

  14. Hull J, Rowlands K, Lockhart E et al (2004) Haplotype mapping of the bronchiolitis susceptibility locus near IL8. Hum Genet 114(3):272–279

    Article  PubMed  CAS  Google Scholar 

  15. Canedo P, Castanheira-Vale AJ, Lunet N et al (2008) The interleukin-8-251*T/*A polymorphism is not associated with risk for gastric carcinoma development in a Portuguese population. Eur J Cancer Prev 17(1):28–32

    Article  PubMed  CAS  Google Scholar 

  16. Hull J, Thomson A, Kwiatkowski D (2000) Association of respiratory syncytial virus bronchiolitis with the interleukin 8 gene region in UK families. Thorax 55(12):1023–1027

    Article  PubMed  CAS  Google Scholar 

  17. Hull J, Ackerman H, Isles K et al (2001) Unusual haplotypic structure of IL8, a susceptibility locus for a common respiratory virus. Am J Hum Genet 69(2):413–419

    Article  PubMed  CAS  Google Scholar 

  18. Taguchi A, Ohmiya N, Shirai K et al (2005) Interleukin-8 promoter polymorphism increases the risk of atrophic gastritis and gastric cancer in Japan. Cancer Epidemiol Biomarkers Prev 14(11 Pt 1):2487–2493

    Article  PubMed  CAS  Google Scholar 

  19. Lee WP, Tai DI, Lan KH et al (2005) The −251T allele of the interleukin-8 promoter is associated with increased risk of gastric carcinoma featuring diffuse-type histopathology in Chinese population. Clin Cancer Res 11(18):6431–6441

    Article  PubMed  CAS  Google Scholar 

  20. Snoussi K, Mahfoudh W, Bouaouina N et al (2010) Combined effects of IL-8 and CXCR2 gene polymorphisms on breast cancer susceptibility and aggressiveness. BMC Cancer 10:283

    Article  PubMed  Google Scholar 

  21. Snoussi K, Mahfoudh W, Bouaouina N et al (2006) Genetic variation in IL-8 associated with increased risk and poor prognosis of breast carcinoma. Hum Immunol 67(1–2):13–21

    Article  PubMed  CAS  Google Scholar 

  22. Kamali-Sarvestani E, Aliparasti MR, Atefi S (2007) Association of interleukin-8 (IL-8 or CXCL8) −251T/A and CXCR2 +1208C/T gene polymorphisms with breast cancer. Neoplasma 54(6):484–489

    PubMed  CAS  Google Scholar 

  23. Vogel U, Christensen J, Nexo BA et al (2007) Peroxisome proliferator-activated [corrected] receptor-gamma2 [corrected] Pro12Ala, interaction with alcohol intake and NSAID use, in relation to risk of breast cancer in a prospective study of Danes. Carcinogenesis 28:427–434

    Article  PubMed  CAS  Google Scholar 

  24. Smith KC, Bateman AC, Fussell HM et al (2004) Cytokine gene polymorphisms, breast cancer susceptibility, prognosis. Eur J Immunogenet 31(4):167–173

    Article  PubMed  CAS  Google Scholar 

  25. Cacev T, Radosević S, Krizanac S et al (2008) Influence of interleukin-8 and interleukin-10 on sporadic colon cancer development and progression. Carcinogenesis 29(8):1572–1580

    Article  PubMed  CAS  Google Scholar 

  26. Wilkening S, Tavelin B, Canzian F et al (2008) Interleukin promoter polymorphisms and prognosis in colorectal cancer. Carcinogenesis 29:1202–1206

    Article  PubMed  CAS  Google Scholar 

  27. Vogel U, Christensen J, Dybdahl M et al (2007) Prospective study of interaction between alcohol, NSAID use and polymorphisms in genes involved in the inflammatory response in relation to risk of colorectal cancer. Mutat Res 624:88–100

    Article  PubMed  CAS  Google Scholar 

  28. Gunter MJ, Canzian F, Landi S et al (2006) Inflammation-related gene polymorphisms, colorectal adenoma. Cancer Epidemiol Biomarkers Prev 15(6):1126–1131

    Article  PubMed  CAS  Google Scholar 

  29. Theodoropoulos G, Papaconstantinou I, Felekouras E et al (2006) Relation between common polymorphisms in genes related to inflammatory response and colorectal cancer. World J Gastroenterol 12(31):5037–5043

    PubMed  CAS  Google Scholar 

  30. Bo S, Dianliang Z, Hongmei Z et al (2010) Association of interleukin-8 gene polymorphism with cachexia from patients with gastric cancer. J Interferon Cytokine Res 30(1):9–14

    Article  PubMed  Google Scholar 

  31. Zhang L, Du C, Guo X et al (2010) Interleukin-8-251A/T polymorphism and Helicobacter pylori infection influence risk for the development of gastric cardiac adenocarcinoma in a high-incidence area of China. Mol Biol Rep 37(8):3983–3989

    Article  PubMed  CAS  Google Scholar 

  32. Song B, Zhang D, Wang S et al (2009) Association of interleukin-8 with cachexia from patients with low-third gastric cancer. Comp Funct Genomics 2009:212345

    Article  Google Scholar 

  33. Ye BD, Kim SG, Park JH et al (2009) The interleukin-8 −251 A allele is associated with increased risk of noncardia gastric adenocarcinoma in Helicobacter pylori-infected Koreans. J Clin Gastroenterol 43:233–239

    Article  PubMed  CAS  Google Scholar 

  34. Ko KP, Park SK, Cho LY et al (2009) Soybean product intake modifies the association between interleukin-10 genetic polymorphisms and gastric cancer risk. J Nutr 139:1008–1012

    Article  PubMed  CAS  Google Scholar 

  35. Kang JM, Kim N, Lee DH et al (2009) The effects of genetic polymorphisms of IL-6, IL-8, and IL-10 on Helicobacter pylori-induced gastroduodenal diseases in Korea. J Clin Gastroenterol 43(5):420–428

    Article  PubMed  CAS  Google Scholar 

  36. Shirai K, Ohmiya N, Taguchi A et al (2006) Interleukin-8 gene polymorphism associated with susceptibility to non-cardia gastric carcinoma with microsatellite instability. J Gastroenterol Hepatol 21(7):1129–1135

    Article  PubMed  CAS  Google Scholar 

  37. Kamali-Sarvestani E, Bazargani A, Masoudian M et al (2006) Association of H. pylori cagA and vacA genotypes and IL-8 gene polymorphisms with clinical outcome of infection in Iranian patients with gastrointestinal diseases. World J Gastroenterol 12:5205–5210

    PubMed  CAS  Google Scholar 

  38. Lu W, Pan K, Zhang L et al (2005) Genetic polymorphisms of interleukin (IL)-1B, IL-1RN, IL-8, IL-10 and tumor necrosis factor alpha and risk of gastric cancer in a Chinese population. Carcinogenesis 26(3):631–636

    Article  PubMed  CAS  Google Scholar 

  39. Ohyauchi M, Imatani A, Yonechi M et al (2005) The polymorphism interleukin 8 −251 A/T influences the susceptibility of Helicobacter pylori related gastric diseases in the Japanese population. Gut 54(3):330–335

    Article  PubMed  CAS  Google Scholar 

  40. Savage SA, Abnet CC, Mark SD et al (2004) Variants of the IL8, IL8RB genes, risk for gastric cardia adenocarcinoma, esophageal squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev 13(12):2251–2257

    PubMed  CAS  Google Scholar 

  41. Crusius JB, Canzian F, Capella G et al (2008) Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST). Ann Oncol 19:1894–1902

    Article  PubMed  CAS  Google Scholar 

  42. Garza-Gonzalez E, Bosques-Padilla FJ, Mendoza-Ibarra SI et al (2007) Assessment of the toll-like receptor 4 Asp299Gly, Thr399Ile, interleukin-8-251 polymorphisms in the risk for the development of distal gastric cancer. BMC Cancer 7:70

    Article  PubMed  Google Scholar 

  43. Kamangar F, Abnet CC, Hutchinson AA et al (2006) Polymorphisms in inflammation-related genes, risk of gastric cancer (Finland). Cancer Causes Control 17(1):117–125

    Article  PubMed  Google Scholar 

  44. Savage SA, Hou L, Lissowska J et al (2006) Interleukin-8 polymorphisms are not associated with gastric cancer risk in a Polish population. Cancer Epidemiol Biomarkers Prev 15(3):589–591

    Article  PubMed  CAS  Google Scholar 

  45. Vogel U, Christensen J, Wallin H et al (2008) Polymorphisms in genes involved in the inflammatory response and interaction with NSAID use or smoking in relation to lung cancer risk in a prospective study. Mutat Res 639:89–100

    Article  PubMed  CAS  Google Scholar 

  46. Campa D, Hung RJ, Mates D et al (2005) Lack of association between −251T>A polymorphism of IL8, lung cancer risk. Cancer Epidemiol Biomarkers Prev 14(10):2457–2458

    Article  PubMed  CAS  Google Scholar 

  47. Campa D, Zienolddiny S, Maggini V et al (2005) Association of a common polymorphism in the cyclooxygenase 2 gene with risk of non-small cell lung cancer. Carcinogenesis 25(2):229–235; Erratum in Carcinogenesis 26(6):1157

    Google Scholar 

  48. Ben Nasr H, Chahed K, Mestiri S et al (2007) Association of IL-8 (−251)T/A polymorphism with susceptibility to and aggressiveness of nasopharyngeal carcinoma. Hum Immunol 68(9):761–769

    Article  PubMed  CAS  Google Scholar 

  49. Wei YS, Lan Y, Tang RG et al (2007) Single nucleotide polymorphism and haplotype association of the interleukin-8 gene with nasopharyngeal carcinoma. Clin Immunol 125(3):309–317

    Article  PubMed  CAS  Google Scholar 

  50. Wang MH, Helzlsouer KJ, Smith MW et al (2009) Association of IL10 and other immune response- and obesity-related genes with prostate cancer in CLUE II. Prostate 69:874–885

    Article  PubMed  CAS  Google Scholar 

  51. Michaud DS, Daugherty SE, Berndt SI et al (2006) Genetic polymorphisms of interleukin-1B (IL-1B), IL-6, IL-8, and IL-10 and risk of prostate cancer. Cancer Res 66(8):4525–4530

    Article  PubMed  CAS  Google Scholar 

  52. Yang HP, Woodson K, Taylor PR et al (2006) Genetic variation in interleukin 8, its receptor genes, its influence on the risk, prognosis of prostate cancer among Finnish men in a large cancer prevention trial. Eur J Cancer Prev 15(3):249–253

    Article  PubMed  CAS  Google Scholar 

  53. McCarron SL, Edwards S, Evans PR et al (2002) Influence of cytokine gene polymorphisms on the development of prostate cancer. Cancer Res 62(12):3369–3372

    PubMed  CAS  Google Scholar 

  54. Shimizu Y, Kondo S, Shirai A et al (2008) A single nucleotide polymorphism in the matrix metalloproteinase-1 and interleukin-8 gene promoter predicts poor prognosis in tongue cancer. Auris Nasus Larynx 35(3):381–389

    Article  PubMed  Google Scholar 

  55. Campa D, Hashibe M, Zaridze D et al (2007) Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract. Cancer Causes Control 18:449–455

    Article  PubMed  Google Scholar 

  56. Vogel U, Christensen J, Wallin H et al (2007) Polymorphisms in COX-2, NSAID use and risk of basal cell carcinoma in a prospective study of Danes. Mutat Res 617:138–146

    Article  PubMed  CAS  Google Scholar 

  57. van der Kuyl AC, Polstra AM, Weverling GJ et al (2004) An IL-8 gene promoter polymorphism is associated with the risk of the development of AIDS-related Kaposi’s sarcoma: a case–control study. AIDS 18:1206–1208

    Article  PubMed  Google Scholar 

  58. Howell WM, Turner SJ, Theaker JM et al (2003) Cytokine gene single nucleotide polymorphisms, susceptibility to, prognosis in cutaneous malignant melanoma. Eur J Immunogenet 30(6):409–414

    Article  PubMed  CAS  Google Scholar 

  59. Zhang J, Dhakal IB, Lang NP et al (2010) Polymorphisms in inflammatory genes, plasma antioxidants, and prostate cancer risk. Cancer Causes Control 21(9):1437–1444

    Article  PubMed  Google Scholar 

  60. Ahirwar DK, Mandhani A, Mittal RD (2010) IL-8 −251 T>A polymorphism is associated with bladder cancer susceptibility, outcome after BCG immunotherapy in a northern Indian cohort. Arch Med Res 41(2):97–103

    Article  PubMed  CAS  Google Scholar 

  61. Kury S, Buecher B, Robiou-du-Pont S et al (2008) Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case–controlled genetic association study. BMC Cancer 8:326

    Article  PubMed  Google Scholar 

  62. Vairaktaris E, Yapijakis C, Serefoglou Z et al (2007) The interleukin-8 (−251A/T) polymorphism is associated with increased risk for oral squamous cell carcinoma. Eur J Surg Oncol 33(4):504–507

    Article  PubMed  CAS  Google Scholar 

  63. Landi S, Moreno V, Gioia-Patricola L et al (2003) Association of common polymorphisms in inflammatory genes interleukin (IL)6, IL8, tumor necrosis factor alpha, NFKB1, and peroxisome proliferator-activated receptor gamma with colorectal cancer. Cancer Res 63(13):3560–3566

    PubMed  CAS  Google Scholar 

  64. Leibovici D, Grossman HB, Dinney CP et al (2005) Polymorphisms in inflammation genes and bladder cancer: from initiation to recurrence, progression, and survival. J Clin Oncol 23(24):5746–5756

    Article  PubMed  CAS  Google Scholar 

  65. Lee KM, Shen M, Chapman RS et al (2007) Polymorphisms in immunoregulatory genes, smoky coal exposure and lung cancer risk in Xuan Wei, China. Carcinogenesis 28:1437–1441

    Article  PubMed  CAS  Google Scholar 

  66. Vairaktaris E, Yapijakis C, Serefoglou Z et al (2008) Gene expression polymorphisms of interleukins-1 beta, -4, -6, -8, -10, and tumor necrosis factors-alpha, -beta: regression analysis of their effect upon oral squamous cell carcinoma. J Cancer Res Clin Oncol 134(8):821–832

    Article  PubMed  CAS  Google Scholar 

  67. Cochran WG (1954) The combination of estimates from different experiments. Biometrics 10:101–129

    Article  Google Scholar 

  68. Higgins JP, Thompson SG, Deeks JJ et al (2003) Measuring inconsistency in meta-analyses. BMJ 327(7414):557–560

    Article  PubMed  Google Scholar 

  69. Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50(4):1088–1101

    Article  PubMed  CAS  Google Scholar 

  70. Egger M, Davey Smith G, Schneider M et al (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315(7109):629–634

    Article  PubMed  CAS  Google Scholar 

  71. Tobias A (1999) Assessing the influence of a single study in the meta-analysis estimate. Stata Tech Bull 8:15–17

    Google Scholar 

  72. Zhang W, Stoehlmacher J, Park DJ et al (2005) Gene polymorphisms of epidermal growth factor receptor, its downstream effector, interleukin-8, predict oxaliplatin efficacy in patients with advanced colorectal cancer. Clin Colorectal Cancer 5(2):124–131

    Article  PubMed  Google Scholar 

  73. Lurje G, Husain H, Power DG et al (2010) Genetic variations in angiogenesis pathway genes associated with clinical outcome in localized gastric adenocarcinoma. Ann Oncol 21(1):78–86

    Article  PubMed  CAS  Google Scholar 

  74. Stocker G, Ott K, Henningsen N et al (2009) CyclinD1 and interleukin-1 receptor antagonist polymorphisms are associated with prognosis in neoadjuvant-treated gastric carcinoma. Eur J Cancer 45(18):3326–3335

    Article  PubMed  CAS  Google Scholar 

  75. Lurje G, Hendifar AE, Schultheis AM et al (2009) Polymorphisms in interleukin 1 beta, interleukin 1 receptor antagonist associated with tumor recurrence in stage II colon cancer. Pharmacogenet Genomics 19(2):95–102

    Article  PubMed  CAS  Google Scholar 

  76. Lurje G, Leers JM, Pohl A et al (2010) Genetic variations in angiogenesis pathway genes predict tumor recurrence in localized adenocarcinoma of the esophagus. Ann Surg 251(5):857–864

    Article  PubMed  Google Scholar 

  77. Reyes-Gibby CC, Shete S, Yennurajalingam S et al (2009) Genetic and nongenetic covariates of pain severity in patients with adenocarcinoma of the pancreas: assessing the influence of cytokine genes. J Pain Symptom Manage 38(6):894–902

    Article  PubMed  CAS  Google Scholar 

  78. Schultheis AM, Lurje G, Rhodes KE et al (2008) Polymorphisms and clinical outcome in recurrent ovarian cancer treated with cyclophosphamide and bevacizumab. Clin Cancer Res 14(22):7554–7563

    Article  PubMed  CAS  Google Scholar 

  79. Lin HC, Liu CC, Kang WY et al (2009) Influence of cytokine gene polymorphisms on prostate-specific antigen recurrence in prostate cancer after radical prostatectomy. Urol Int 83(4):463–470

    Article  PubMed  CAS  Google Scholar 

  80. Wang J, Pan HF, Hu YT et al (2010) Polymorphism of IL-8 in 251 allele and gastric cancer susceptibility: a meta-analysis. Dig Dis Sci 55(7):1818–1823

    Article  PubMed  CAS  Google Scholar 

  81. Liu L, Zhuang W, Wang C et al (2010) Interleukin-8 −251 A/T gene polymorphism and gastric cancer susceptibility: a meta-analysis of epidemiological studies. Cytokine 50(3):328–334

    Article  PubMed  CAS  Google Scholar 

  82. Gao LB, Pan XM, Jia J et al (2010) IL-8 −251A/T polymorphism is associated with decreased cancer risk among population-based studies: evidence from a meta-analysis. Eur J Cancer 46(8):1333–1343

    Article  PubMed  CAS  Google Scholar 

  83. Lee M, Lee Y, Cho HJ et al (2011) Copy number variations of chromosome 17p13.1 might be linked to high risk of lung cancer in heavy smokers. Mol Biol Rep. doi:10.1007/s11033-010-0672-3

  84. Zhang Q, Li Y, Li X et al (2009) PARP-1 Val762Ala polymorphism, CagA+ H. pylori infection, risk for gastric cancer in Han Chinese population. Mol Biol Rep 36(6):1461–1467

    Article  PubMed  CAS  Google Scholar 

  85. Duan S, Zhang G, Han Q et al (2010) CTLA-4 exon 1 +49 polymorphism alone and in a haplotype with −318 promoter polymorphism may confer susceptibility to chronic HBV infection in Chinese Han patients. Mol Biol Rep. doi:10.1007/s11033-010-0660-7

Download references

Acknowledgments

We greatly acknowledge Dr. Vogel [23], Dr. Ko [34] and Dr. Zhang [59], for they have provided the frequencies of IL-8 −251 T/A polymorphism between the cases and controls in detail. We also greatly acknowledge Stacey Dial (Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, USA) for her helpful comments. This work is supported by funds for the potentially distinguished scientific project construction program in Hebei universities.

Author information

Authors and Affiliations

  1. Department of Molecular Biology, The Fourth Hospital of Hebei Medical University, Jiankang Road 12, Shijiazhuang, 050011, Hebei, China

    Na Wang, Rongmiao Zhou & Yan Li

  2. Department of Biology, School of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China

    Chunmei Wang

  3. Department of Endoscopy, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China

    Xiaoqing Guo

  4. Department of Cancer Prevention and Control, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China

    Zhifeng Chen

  5. Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China

    Shan Yang

Authors
  1. Na Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rongmiao Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Chunmei Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Xiaoqing Guo
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Zhifeng Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Shan Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yan Li
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yan Li.

Additional information

Our study indicated that −251A allele of the interleukin-8 gene was emerging as a low-penetrance cancer susceptibility allele for the development of cancers.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (DOCX 18 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wang, N., Zhou, R., Wang, C. et al. −251 T/A polymorphism of the interleukin-8 gene and cancer risk: a HuGE review and meta-analysis based on 42 case–control studies. Mol Biol Rep 39, 2831–2841 (2012). https://doi.org/10.1007/s11033-011-1042-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11033-011-1042-5

Keywords

Search

Navigation