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Polymorphism of IL-8 in 251 Allele and Gastric Cancer Susceptibility: A Meta-Analysis

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Abstract

Background

The relationship of gastric cancer to the presence of interleukin-8 (IL-8) 251 T/A has been reported with conflicting results.

Aim

To further explore the association of IL-8 251 allele polymorphism with gastric cancer susceptibility.

Methods

We performed an extensive search of relevant studies and carried out a meta-analysis, including ten studies with 2,195 gastric cancer cases and 3,505 controls, to obtain a more precise estimate.

Results

The combined results based on all studies showed that the IL-8 251 allele AA genotype was a risk factor for gastric cancer [AA versus TT: odds ratio (OR) = 1.363, 95% confidence interval (CI): 1.199–1.527]. In subgroup analysis, a clear effect of AA in IL-8 251 allele was shown in Asians (AA versus TT: OR = 1.593, 95% CI: 1.013–2.173) but not in Caucasians or Mexicans. When stratified by Lauren classification, we found that the IL-8 251 allele TA and AA polymorphism was significantly associated with the diffuse type of gastric cancer (TA versus TT: OR = 1.448, 95% CI: 1.177–1.720; AA versus TT: OR = 1.586, 95% CI: 1.128–2.044). The IL-8 251 AA genotype was found to be a risk factor for cardiac gastric cancer (AA versus TT: OR = 1.840, 95% CI: 1.112–2.568) but not for noncardiac gastric cancer.

Conclusions

This meta-analysis suggested that IL-8 251 allele A>T polymorphism might be a risk factor for gastric cancer.

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Acknowledgments

This research was supported by the Humane and Social Sciences Research Fund, Education Department of Anhui Province (reference: 2009sk192zd), Cademic Leader Foundation of Anhui Medical University, and Doctor’s Scientific Research Foundation of Anhui Medical University. At the same time, thanks are due to Dr. De bin Wang for help in the revision of the manuscript.

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Authors and Affiliations

  1. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, 230032, Hefei, Anhui, People’s Republic of China

    Jing Wang, Hai-Feng Pan, Yu Zhu & Qian He

  2. Department of Clinical Medicine, Anhui Medical University, Hefei, Anhui, People’s Republic of China

    Yun-Tao Hu

Authors
  1. Jing Wang
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  2. Hai-Feng Pan
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  3. Yun-Tao Hu
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  4. Yu Zhu
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Correspondence to Jing Wang.

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Wang, J., Pan, HF., Hu, YT. et al. Polymorphism of IL-8 in 251 Allele and Gastric Cancer Susceptibility: A Meta-Analysis. Dig Dis Sci 55, 1818–1823 (2010). https://doi.org/10.1007/s10620-009-0978-y

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  • DOI: https://doi.org/10.1007/s10620-009-0978-y

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