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Quantitative assessment of the effect of ABCA1 R219K polymorphism on the risk of coronary heart disease

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Abstract

In the past decade, a number of case-control studies have been conducted to investigate the relationship between the ATP-binding cassette transporter A1 (ABCA1) R219K polymorphism and coronary heart disease (CHD). However, the results have been inconclusive. The purpose of the present study is to investigate whether this polymorphism confers significant susceptibility to CHD using a meta-analysis. PubMed, Embase and CNKI database were searched to get the genetic association studies. Then data were extracted. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated. Moreover, subgroup and sensitive analysis were performed. In total, 9,437 cases and 16,270 controls were involved in the meta-analysis. The K219 was significantly associated with CHD (OR = 0.80, 95% CI 0.69–0.92, P(Z) = 0.001). However, significant heterogeneity was present. Further subgroup analysis suggested ethnicity explained much heterogeneity. In Asians, K219 showed a strong protective effect and the pooled OR was 0.69 (95% CI 0.55–0.86 P(Z) = 0.0009). While in Caucasians the result was not significant (OR = 0.87, 95% CI 0.73–1.04, P(Z) = 0.12). In conclusion, our results indicate that the ABCA1 R219K polymorphism is a protective factor of CHD in Asians, but not in Caucasians.

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Acknowledgments

This work was supported by the 973 Program (2010CB529600, 2007CB947300), the 863 Program (2009AA022701), the National Nature Science Foundation of China (31071159), the Shanghai Municipal Commission of Science and Technology Program (09DJ1400601), the National Key Technology R&D Program (2006BAI05A09), the National Key Project for Investigational New Drugs 2008ZX09312-003, the Shanghai Leading Academic Discipline Project (B205).

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Authors and Affiliations

  1. Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai, 200030, China

    Yang Li, Kefu Tang, Kejun Zhou, Zhiyun Wei, Zhen Zeng, Lin He & Chunling Wan

  2. Institutes for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, 200031, China

    Yang Li, Kefu Tang, Kejun Zhou, Zhiyun Wei, Zhen Zeng, Lin He & Chunling Wan

  3. Institutes of Biomedical Sciences, Fudan University, 130 Dongan Road, Shanghai, 200032, China

    Lin He

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  1. Yang Li
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  2. Kefu Tang
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  3. Kejun Zhou
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  4. Zhiyun Wei
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  5. Zhen Zeng
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Correspondence to Lin He or Chunling Wan.

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Li, Y., Tang, K., Zhou, K. et al. Quantitative assessment of the effect of ABCA1 R219K polymorphism on the risk of coronary heart disease. Mol Biol Rep 39, 1809–1813 (2012). https://doi.org/10.1007/s11033-011-0922-z

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  • DOI: https://doi.org/10.1007/s11033-011-0922-z

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