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Association of IL-10−1082 G/G genotype with lower mortality of acute respiratory distress syndrome in a Chinese population

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Abstract

We aimed to investigate whether interleukin-10 (IL-10) −1082 G/G genotype is associated with lower mortality of acute respiratory distress syndrome (ARDS) in a Chinese population. A hospital-based case–control study was conducted in 314 cases of ARDS and 210 controls who were admitted to an intensive care unit with sepsis, trauma, aspiration or massive transfusions. Cases were followed for 30-day mortality. The −1082G/G genotype was associated with lower development of ARDS (OR = 0.51; 95% CI 0.34–0.76; P = 0.001). Among patients with ARDS, the −1082G/G genotype was associated with lower 30-day mortality (OR = 0.44; 95% CI 0.25–0.76; P = 0.003). In conclusion, IL-10−1082 G/G genotype is associated with lower development and mortality of ARDS in a Chinese population.

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Authors and Affiliations

  1. Intensive Care Unit, West China Hospital, Sichuan University, 37 Guo Xue Road, Chengdu, 610041, Sichuan, China

    Xiaodong Jin, Zhi Hu, Yan Kang, Chang Liu, Yongfang Zhou, Xiaodong Wu, Mingxing Zhong, Chuanxing Luo, Lijing Deng, Yiyun Deng, Xiaoqi Xie, Zhongwei Zhang, Yan Zhou & Xuelian Liao

  2. The Anesthesiology and Critical Care Medicine Teaching and Research Division, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China

    Jin Liu

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  1. Xiaodong Jin
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  2. Zhi Hu
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  3. Yan Kang
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  4. Chang Liu
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Correspondence to Xiaodong Jin.

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Jin, X., Hu, Z., Kang, Y. et al. Association of IL-10−1082 G/G genotype with lower mortality of acute respiratory distress syndrome in a Chinese population. Mol Biol Rep 39, 1–4 (2012). https://doi.org/10.1007/s11033-010-0377-7

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  • DOI: https://doi.org/10.1007/s11033-010-0377-7

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