Skip to main content

Advertisement

SpringerLink
Log in

TNF-308 gene polymorphism is associated with COPD risk among Asians: meta-analysis of data for 6,118 subjects

  • Published:
Molecular Biology Reports Aims and scope Submit manuscript

Abstract

Chronic obstructive pulmonary disease (COPD) is a complex polygenic disease in which gene–environment interactions play a critical role in disease onset and progression. The gene encoding tumor necrosis factor (TNF) is one of several candidate loci for the pathogenesis of COPD and is highly polymorphic. A number of studies have investigated the association between the TNF-308 polymorphisms and COPD risk in different populations, and resulted in inconsistent results. A systematic review and meta-analysis of the published studies were performed to gain a clearer understanding of this association. The PubMed, Embase, Web of Science, and CNKI databases were searched for case–control studies published from 1966 to April 2009. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. Twenty-four eligible studies, comprising 2,380 COPD cases and 3,738 controls, were included in the meta-analysis. The pooled result showed that the TNF-308 polymorphisms were significantly associated with an increased risk of COPD (OR = 1.335, 95% CI: 1.172–1.522, for allele A carriers versus G/G; OR = 1.330, 95% CI = 1.174–1.505, for allele A versus allele G). Subgroup analysis supported the results in the Asian populations, but not in the Caucasian populations. When the analysis was limited to only those studies in which the COPD cases and controls were smokers/ex-smokers, the pooled results supported the conclusion. This meta-analysis suggested that the TNF-308 A allele is a more significant risk factor for developing COPD among Asian populations, but not among Caucasians.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Pauwels RA, Buist AS, Calverley PM, Jenkins CR, Hurd SS (2001) Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am J Respir Crit Care Med 163:1256–1276. Updated version 2006 is available from URL: http://www.goldcopd.org/

  2. Mannino DM, Homa DM, Akinbami LJ, Ford ES, Redd SC (2002) Chronic obstructive pulmonary disease surveillance-United States, 1971–2000. MMWR Surveill Summ 51:1–16

    Google Scholar 

  3. Silverman EK (2002) Genetic epidemiology of COPD. Chest 121:1S–6S

    Article  PubMed  Google Scholar 

  4. Sandford AJ, Silverman EK (2002) Chronic obstructive pulmonary disease: susceptibility factors for COPD the genotype-environment interaction. Thorax 57:736–741

    Article  CAS  PubMed  Google Scholar 

  5. Koyama H, Geddes DM (1998) Genes, oxidative stress, and the risk of chronic obstructive pulmonary disease. Thorax 53(Suppl 2):S10–S14

    Article  PubMed  Google Scholar 

  6. Molfino NA (2004) Genetics of COPD. Chest 125:1929–1940

    Article  PubMed  Google Scholar 

  7. Keatings VM, Collins PD, Scott DM, Barnes PJ (1996) Differences in interleukin-8 and tumor necrosis factor-α in induced sputum from patients with chronic obstructive pulmonary disease or asthma. Am J Respir Crit Care Med 153:530–534

    CAS  PubMed  Google Scholar 

  8. Wilson AG, di Giovine FS, Blakemore AIF et al (1992) Single base polymorphism in the human TNFα gene detectable by Nco1 restriction of PCR product. Hum Mol Genet 1:353

    Article  CAS  PubMed  Google Scholar 

  9. Kroeger KM, Carville KS, Abraham LJ (1997) The -308 tumor necrosis factor-α promoter polymorphism effects transcription. Mol Immunol 34:391–399

    Article  CAS  PubMed  Google Scholar 

  10. Wilson AG, Symons JA, McDowell TL et al (1997) Effects of a polymorphism in the human tumor necrosis factor-α promoter on transcriptional activation. Proc Natl Acad Sci USA 94:3195–3199

    Article  CAS  PubMed  Google Scholar 

  11. Brogger J, Steen VM, Eiken HG, Gulsvik A, Bakke P (2006) Genetic association between COPD and polymorphisms in TNF, ADRB2 and EPHX1. Eur Respir J 27:682–688

    Article  CAS  PubMed  Google Scholar 

  12. Gingo MR, Silveira LJ, Miller YE et al (2008) Tumour necrosis factor gene polymorphisms are associated with COPD. Eur Respir J 31:1005–1012

    Article  CAS  PubMed  Google Scholar 

  13. Cochran WG (1954) The combination of estimates from different experiments. Biometrics 10:101–129

    Article  Google Scholar 

  14. Mantel N, Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22:719–748

    CAS  PubMed  Google Scholar 

  15. DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177–188

    Article  CAS  PubMed  Google Scholar 

  16. Tobias A (1999) Assessing the influence of a single study in the meta-analysis estimate. Stata Tech Bull 8:15–17

    Google Scholar 

  17. Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in metaanalysis detected by a simple, graphical test. BMJ 315:629–634

    CAS  PubMed  Google Scholar 

  18. Jiang P, Li Y (2006) Association among genetic polymorphisms of HO21, TNF2α and chronic obstructive pulmonary disease. J Shangdong Univ 44:1253–1257 (in Chinese)

    CAS  Google Scholar 

  19. Hsieh MH, Chong IW, Hwang JJ, Lee CH et al (2008) Lack of associations between several polymorphisms in cytokine genes and the risk of chronic obstructive pulmonary diseases in Taiwan. Kaohsiung J Med Sci 24:126–137

    Article  CAS  PubMed  Google Scholar 

  20. Zhang YQ, Lu BQ (2008) Analysis of TNFA and LTA-gene allele variation in COPD. Chin J Gerontol 19:1909–1911 (in Chinese)

    Google Scholar 

  21. Du Y, Sun SM, Li Y (2008) The Relationship between genetic polymorphism of tumor necrosis factor-α, humanβ-defensin-1 and the development of chronic obstructive pulmonary disease. Clinical Medical Journal of China 15:329–331 (in Chinese)

    Google Scholar 

  22. Gong Y, Jin ML, Ren T et al (2008) Association of tumor necrosis factor gene promoter polymorphism with chronic obstructive pulmonary disease. Clin Med J China 15:166–169 (in Chinese)

    Google Scholar 

  23. Shi YZ, Liu B, Zhang W et al (2007) Association between tumor necrosis factor-α olymorphisms and chronic obstructive pulmonary disease in Heirongjiang province. Chin J Tuberc Respir Dis 30:233–234 (in Chinese)

    CAS  Google Scholar 

  24. Zhang Y, Wang W, Xu SH et al (2007) Association between polymorphism in the gene coding for tumor necrosis factor-α and chronic obstructive pulmonary disease. J Taishan Med Coll 28:106–109 (in Chinese)

    Google Scholar 

  25. Papatheodorou A, Latsi P, Vrettou C et al (2007) Development of a novel microarray methodology for the study of SNPs in the promoter region of the TNF-alpha gene: their association with obstructive pulmonary disease in Greek patients. Clin Biochem 40:843–850

    Article  CAS  PubMed  Google Scholar 

  26. Broekhuizen R, Grimble RF, Howell WM, Shale DJ, Creutzberg EC, Wouters EF, Schols AM (2005) Pulmonary cachexia, systemic inflammatory profile, and the interleukin 1beta -511 single nucleotide polymorphism. Am J Clin Nutr 82:1059–1064

    CAS  PubMed  Google Scholar 

  27. Seifart C, Dempfle A, Plagens A, Seifart U, Clostermann U, Müller B, Vogelmeier C, von Wichert P (2005) TNF-alpha-, TNF-beta-, IL-6-, and IL-10-promoter polymorphisms in patients with chronic obstructive pulmonary disease. Tissue Antigens 65:93–100

    Article  CAS  PubMed  Google Scholar 

  28. Chierakul N, Wongwisutikul P, Vejbaesya S, Chotvilaiwan K (2005) Tumor necrosis factor-alpha gene promoter polymorphism is not associated with smoking-related COPD in Thailand. Respirology 10:36–39

    Article  PubMed  Google Scholar 

  29. Hegab AE, Sakamoto T, Saitoh W et al (2005) Polymorphisms of TNF-α, IL1β, and IL1RN genes in chronic obstructive pulmonary disease. Biochem Biophys Res Commun 329:1246–1252

    Article  CAS  PubMed  Google Scholar 

  30. Ma ZM, Zhang ZX, Han ZM et al (2005) A study on the relationship between tumor necrosis factor α gene promoter polymorphism and the expressive levels of TNF2α protein. J Clin Intern Med 22:230–232 (in Chinese)

    Google Scholar 

  31. Jiang L, He B, Zhao MW, Ning LD, Li XY, Yao WZ (2005) Association of gene polymorphisms of tumour necrosis factor-alpha and interleukin-13 with chronic obstructive pulmonary disease in Han nationality in Beijing. Chin Med J (Engl) 118:541–547

    CAS  Google Scholar 

  32. Zui FZ, Li Y, Wang L et al (2004) Association between tumor necrosis factor-α olymorphisms and chronic obstructive pulmonary disease [in Chinese]. J Shandong Univ 42:711–720

    Google Scholar 

  33. Ma ZM, Zhang ZX, Han ZM et al (2004) A study on relationship between tumor necrosis factor α gene promoter polymorphism and susceptibility to development of COPD. Pract Prev Med 11:417–419 (in Chinese)

    Google Scholar 

  34. Ferrarotti I, Zorzetto M, Beccaria M, Gilè LS, Porta R, Ambrosino N, Pignatti PF, Cerveri I, Pozzi E, Luisetti M (2003) Tumour necrosis factor family genes in a phenotype of COPD associated with emphysema. Eur Respir J 21:444–449

    Article  CAS  PubMed  Google Scholar 

  35. He B, Jiang L, Ning LD et al (2003) Tumor necrosis factor-α gene 308 A allele can predispose to chronic obstructive pulmonary disease in smokers. Chin J Respir Crit Care Med 12:226–229 (in Chinese)

    Google Scholar 

  36. Kucukaycan M, Van Krugten M, Pennings HJ, Huizinga TW, Buurman WA, Dentener MA, Wouters EF (2002) Tumor necrosis factor-alpha +489G/A gene polymorphism is associated with chronic obstructive pulmonary disease. Respir Res 3:29

    Article  PubMed  Google Scholar 

  37. Sakao S, Tatsumi K, Igari H, Shino Y, Shirasawa H, Kuriyama T (2001) Association of tumor necrosis factor alpha gene promoter polymorphism with the presence of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 163:420–422

    CAS  PubMed  Google Scholar 

  38. Higham MA, Pride NB, Alikhan A, Morrell NW (2000) Tumour necrosis factor-alpha gene promoter polymorphism in chronic obstructive pulmonary disease. Eur Respir J 15:281–284

    Article  CAS  PubMed  Google Scholar 

  39. Keatings V, Cave S, Henry M et al (2000) A polymorphism in the tumor necrosis factor-α gene promoter region may predispose to a poor prognosis in COPD. Chest 118:971–975

    Article  CAS  PubMed  Google Scholar 

  40. Huang SL, Su CH, Chang SC (1997) Tumor necrosis factor-α gene polymorphism in chronic bronchitis. Am J Respir Crit Care Med 156:1436–1439

    CAS  PubMed  Google Scholar 

  41. COPD Branch in Chinese Thoracic Society (2002) The guideline of diagnosis and management for COPD. Chin J Tuberc Respir Dis 25:453–460

    Google Scholar 

  42. American Thoracic Society (1995) Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 152:S77–S120

    Google Scholar 

  43. Chinese Thoracic Society (1997) The guideline of diagnosis and management for COPD. Chin J Tuberc Respir Dis 20:199–233

    Google Scholar 

  44. British Thoracic Society (1997) BTS guidelines for the management of chronic obstructive pulmonary disease. The COPD Guidelines Group of the Standards of Care Committee of the BTS. Thorax 52(Suppl 15):S1–S28

    Google Scholar 

  45. Farber JL (1994) Mechanisms of cell injury by activated oxygen species. Environ Health Perspect 102:17–24

    Article  CAS  PubMed  Google Scholar 

  46. Rahman I, Swarska E, Henry M, Stolk J, MacNee W (2000) Is there any relationship between plasma antioxidant capacity and lung function in smokers and in patients with chronic obstructive pulmonary disease? Thorax 55:189–193

    Article  CAS  PubMed  Google Scholar 

  47. Lomas DA, Silverman EK (2001) The genetics of chronic obstructive pulmonary disease. Respir Res 2:20–26

    Article  CAS  PubMed  Google Scholar 

  48. Hirschhorn JN, Lohmueller K, Byrne E (2002) A comprehensive review of genetic association studies. Genet Med 4:45–61

    Article  CAS  PubMed  Google Scholar 

  49. Lee YH, Woo J-H, Choi SJ, Ji JD, Song GG (2009) Functional monocyte chemoattractant protein-1 promoter –2518 polymorphism and systemic lupus erythematosus: a meta-analysis. Mol Biol Rep. doi:10.1007/s11033-009-9932-5

    Google Scholar 

  50. Mao C, Pan H, Chen Q, Wang X, Ye D, Qiu L (2010) Association between Fc receptor-like 3 C169T polymorphism and risk of systemic lupus erythematosus: a meta-analysis. Mol Biol Rep 37:191–196

    Article  CAS  PubMed  Google Scholar 

  51. Ji JD, Lee WJ, Kong KA, Woo JH, Choi SJ, Lee YH, Song GG (2010) Association of STAT4 polymorphism with rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis. Mol Biol Rep 37:141–147

    Article  CAS  PubMed  Google Scholar 

  52. Yuan H, Pan HF, Li LH, Feng JB, Li WX, Li XP, Ye DQ (2009) Meta analysis on the association between FcgammaRIIa-R/H131 polymorphisms and systemic lupus erythematosus. Mol Biol Rep 36:1053–1058

    Article  CAS  PubMed  Google Scholar 

  53. Liao R-Y, Mao C, Qiu L-X, Ding H, Chen Q, Pan H-F (2009) TGFBR1*6A/9A polymorphism and cancer risk: a meta-analysis of 13,662 cases and 14,147 controls. Mol Biol Rep. doi:10.1007/s11033-009-9906-7

    Google Scholar 

  54. Li L, Huang X, Huo K (2010) IGFBP3 polymorphisms and risk of cancer: a meta-analysis. Mol Biol Rep 37:127–140

    Article  PubMed  Google Scholar 

  55. Zhu W, Wei BB, Shan X, Liu P (2010) 765G>C and 8473T>C polymorphisms of COX-2 and cancer risk: a meta-analysis based on 33 case-control studies. Mol Biol Rep 37:277–288

    Article  CAS  PubMed  Google Scholar 

  56. Li C, Jiang Z, Liu X (2010) XPD Lys(751)Gln and Asp (312)Asn polymorphisms and bladder cancer risk: a meta-analysis. Mol Biol Rep 37:301–309

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

This study was supported in part by a grant from the Great Medical Research Program of the Nanjing Sanitary Bureau of Jiangsu Province “Personalized Therapy of No Small Cell Lung Cancer Patients”, and the Jiangsu province Natural Science Foundation of China (BK2008326).

Author information

Authors and Affiliations

  1. First Department of Respiratory Medicine, Nanjing Chest Hospital, 215 Guangzhou Road, Nanjing, 210029, China

    Ping Zhan & Li-Ke Yu

  2. Department of Hematology, The Affiliated Drum Tower Hospital of Nanjing University School of Medicine, Nanjing, 210008, China

    Jing Wang

  3. Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, 305 East Zhongshan Road, Nanjing, 210002, China

    Shu-Zhen Wei, Qian Qian & Yong Song

  4. Department of Medical Oncology, Cancer Hospital, Shanghai Medical College, Fudan University, Shanghai, China

    Li-Xin Qiu

Authors
  1. Ping Zhan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jing Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shu-Zhen Wei
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Qian Qian
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Li-Xin Qiu
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Li-Ke Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yong Song
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Li-Ke Yu or Yong Song.

Additional information

P. Zhan and J. Wang contributed equally to this work and should be considered as co-first authors.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zhan, P., Wang, J., Wei, SZ. et al. TNF-308 gene polymorphism is associated with COPD risk among Asians: meta-analysis of data for 6,118 subjects. Mol Biol Rep 38, 219–227 (2011). https://doi.org/10.1007/s11033-010-0098-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11033-010-0098-y

Keywords

Search

Navigation