Abstract
The neurite outgrowth inhibitor Nogo has attracted great interest, but its relevance with hepatocellular carcinoma has not been reported. This paper first found mutations of Nogo-C in HCC patients from Qidong in China: A172G (Thr58Ala), A340G (Arg114Gly), A571G (Ile191Val). In six examined patient cases from Qidong, the mutations occurred in five cases. The mutation Arg114Gly was predicted bioinformatically to affect Nogo-66 dimensional structure of Nogo-C. Our previous works also had indicated that mutant Nogo-C promoted liver cancer cell line apoptosis and resulted in molecular marker of HCC p53 gene transfer from nucleus to cytoplast. Above results revealed a new physiological role and clinical implications of Nogo-C on HCC.
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Acknowledgments
We thank Dr. Chuanjun Wen at the Jiangsu Key Laboratory of Molecular and Medical Biotechnology and Dr. Dongdong Lu for providing us the HCC patient cases.
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Chen, Y., Tang, X., Zhang, X. et al. New mutations of Nogo-C in hepatocellular carcinoma. Mol Biol Rep 36, 377–380 (2009). https://doi.org/10.1007/s11033-007-9190-3
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DOI: https://doi.org/10.1007/s11033-007-9190-3