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Genetic polymorphisms of XRCC1 (at codons 194 and 399) in Shiraz population (Fars province, southern Iran)

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Abstract

Objective Several potential functional polymorphisms in the DNA base excision repair gene X-ray repair cross-complementing group 1 (XRCC1) have been reported. There has been no information on interindividual variability of Arg194Trp and Arg399Gln polymorphisms of XRCC1 in the Iranian population. Due to the association between the polymorphisms of XRCC1 and the risk of some types of cancers, the present study was done. Methods The genetic polymorphisms of XRCC1 were detected by PCR-based method in 707 healthy individuals from Shiraz population, (Fars province, southern Iran). Results Considering that there was no statistically significant difference between males and females, the sex groups were pooled. The frequencies of 194Trp and 399Gln alleles were 9.05% and 33.95%, respectively. When both polymorphisms were considered, the linkage-disequilibrium was observed (D′ = 0.8986, r 2 = 0.0413, P < 0.00001). Conclusion The present results indicated that the allelic frequencies in Iranian populations showed intermediate frequencies in comparison with European and other Asian countries.

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References

  1. Cardecott KW (2003) XRCC1 and DNA stand break repair. DNA Repiar 2:955–969

    Article  Google Scholar 

  2. Hu Z, Ma H, Chen F et al (2005) XRCC1 polymorphisms and cancer risk: a meta-analysis of 38 case-control studies. Cancer Epidemiol Biomarkers Prev 14:1810–1818

    Article  PubMed  CAS  Google Scholar 

  3. Hung RJ, Hall J, Bernnan P et al (2005) Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review. Am J Epidemiol 162:925–942

    Article  PubMed  Google Scholar 

  4. Goode EL, Ulrich CM, Potter JD (2002) Polymorphisms in DNA repair genes and associations with cancer risk. Cancer Epidemiol Biomarkers Prev 11:1513–1530

    PubMed  CAS  Google Scholar 

  5. Amirshahi P, Sunderland E, Farhud DD et al (1992) Population genetics of the peoples of Iran. I. Genetic polymorphisms of blood groups, serum proteins and red cell enzymes. Int J Anthropol 7:1–10

    Article  Google Scholar 

  6. Saadat M, Amirshahi P, Farhud DD (1997) ABO and Rh blood groups distribution in the populations of Laerstan and Lamerd, Fars province, Iran. Iran J Public Health 25:21–26

    Google Scholar 

  7. Kamkar M, Saadat M, Saadat I et al (2003) Report of VNTR with 13 repeats linked to phenylalanine hydoxylase locus in unaffected members of two PKU families. Iran Biomed J 7:89–90

    CAS  Google Scholar 

  8. Saadat M (2006) Genetic polymorphisms of glutathione S-transferase T1 (GSTT1) and susceptibility to gastric cancer, a meta-analysis. Cancer Sci 97:505–509

    Article  PubMed  CAS  Google Scholar 

  9. Saadat M, Dadbine-Pour A (2005) Influence of polymorphism of glutathione S-transferase M1 on systolic blood pressure of normotensive individuals. Biochem Biophys Res Commun 326:449–454

    Article  PubMed  CAS  Google Scholar 

  10. Saadat M, Farhud DD, Saadat I (2001) Frequency of glutathione S-transferase M1 (GSTM1) and GSTT1 null genotypes in Fars population (south of Iran). Iran J Public Health 30:83–86

    CAS  Google Scholar 

  11. Saadat M, Farhud DD (2005) Frequency of genetic polymorphism of the gene encoding 16 KDa Clara cell secretory pprotein (CC16) in Shiraz, Iran. Iran J Public Health 34:27–30

    CAS  Google Scholar 

  12. Saadat M, Kamkar M, Mohabbatkar H et al (2003) High frequency of IVS10nt546 linked to VNTR 8 in Iranian PKU patients from Fars province. Iran Biomed J 7:145

    Google Scholar 

  13. Saadat M, Saadat I, Saboori Z et al (2004) Combination of CC16, GSTM1, and GSTT1 genetic polymorphisms is associated with asthma. J Allergy Clin Immunol 113:996–668

    Article  PubMed  CAS  Google Scholar 

  14. Saadat M, Pakyari N, Farrashbandi H (2007) Genetic polymorphism in the DNA repair gene XRCC1 and susceptibility to schizophrenia. Psychiatry Res, doi:10.1016/j.psychers.2007.07.014

  15. Abdel-Rahman SZ, El-Zein RA (2000) The 399Gln polymorphism in the DNA repair gene XRCC1 modulates the genotoxic response induced in human lymphocytes by tobacco-specific nitrosamine NNK. Cancer Lett 159:63–71

    Article  PubMed  CAS  Google Scholar 

  16. Lunn RM, Langlois RG, Hsieh LL et al (1999) XRCC1 polymorphisms: effects on aftatoxin B DNA adducts and glycophorin A variant frequency. Cancer Res 59:255–256

    Google Scholar 

  17. Hu JJ, Smith TR, Miller MS et al (2001) Amino acid substitution variants of APE1 and XRCC1 genes associated with ionizing radiation sensitivity. Carcinogenesis 22:917–922

    Article  PubMed  CAS  Google Scholar 

  18. Duell EJ, Millikan RC, Pittman GS et al (2001) Polymorphisms in the DNA repair gene XRCC1 and breast cancer. Cancer Epidemiol Biomarkers Prev 10:217–222

    PubMed  CAS  Google Scholar 

  19. Shu XO, Cai Q, Gao YT et al (2003) A population-based case-control study of the Arg399Gln polymorphism in DNA repair gene XRCC1 and risk of breast cancer. Cancer Epidemiol Biomarkers Prev 12:1462–1467

    PubMed  CAS  Google Scholar 

  20. Ratnasingle D, Yao SX, Tangvea JA et al (2001) Polymorphisms of the DNA repair gene XRCC1 and lung cancer risk. Cancer Epidemiol Biomarkers Prev 10:119–123

    Google Scholar 

  21. Chacko P, Rajan B, Joseph T et al (2005) Polymorphisms in DNA repair gene XRCC1 and increased genetic susceptibility to breast cancer. Breast Cancer Res Treat 89:15–21

    Article  PubMed  CAS  Google Scholar 

  22. Matsuo K, Hamajima N, Suzuki R et al (2004) Lack of association between DNA base excision repair gene XRCC1 Gln399Arg polymorphism and risk of malignant lymphoma in Japan. Cancer Genet Cytogenet 149:77–80

    Article  PubMed  CAS  Google Scholar 

  23. Kim SU, Park SK, Yoo KY et al (2002) XRCC1 genetic polymorphism and breast cancer risk. Pharmacogenetics 12:335–338

    Article  PubMed  CAS  Google Scholar 

  24. Deligezer U, Dalay N (2004) Association of the XRCC1 gene polymorphisms with cancer risk in Turkish breast cancer patients. Exp Mol Med 36:572–575

    PubMed  CAS  Google Scholar 

  25. Forsti A, Angelini S, Festa F et al (2004) Single nucleotide polymorphisms in breast cancer. Oncol Rep 11:917–922

    PubMed  Google Scholar 

  26. Moullan N, Cox DG, Angele S et al (2003) Polymorphisms in the DNA repair gene XRCC1, breast cancer risk, and response to radiotherapy. Cancer Epidemiol Biomarkers Prev 12:1168–1174

    PubMed  CAS  Google Scholar 

  27. Varzim G, Monteiro E, Silva RA et al (2003) CYP1A1 and XRCC1 gene polymorphisms in SCC of the larynx. Eur J Cancer Prev 12:495–499

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

The authors are indebted to the participants for their close cooperation. This study was supported by Shiraz University.

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Authors and Affiliations

  1. Department of Biology, College of Sciences, Shiraz University, Shiraz, 71454, Iran

    Parisa Mohamadynejad & Mostafa Saadat

  2. Institute of Biotechnology, Shiraz University, Shiraz, Iran

    Parisa Mohamadynejad & Mostafa Saadat

Authors
  1. Parisa Mohamadynejad
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  2. Mostafa Saadat
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Correspondence to Mostafa Saadat.

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Mohamadynejad, P., Saadat, M. Genetic polymorphisms of XRCC1 (at codons 194 and 399) in Shiraz population (Fars province, southern Iran). Mol Biol Rep 35, 669–672 (2008). https://doi.org/10.1007/s11033-007-9138-7

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  • DOI: https://doi.org/10.1007/s11033-007-9138-7

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