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Synthesis of new curcumin-based aminocarbonitrile derivatives incorporating 4H-pyran and 1,4-dihydropyridine heterocycles

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Abstract

A multicomponent reaction containing curcumin, aldehydes, malononitrile and amine was developed for the one-pot synthesis of a novel library of 4H-pyran and 1,4-dihyropyridin heterocycles incorporating curcumin moiety. The products were obtained in the presence of p-toluenesulfonic acid as catalyst in ethanol as solvent in good to excellent yields.

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  1. Department of Chemistry, College of Sciences, Shiraz University, Shiraz, 71454, Iran

    Soheila Khajeh Dangolani, Farhad Panahi & Ali Khalafi-Nezhad

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Khajeh Dangolani, S., Panahi, F. & Khalafi-Nezhad, A. Synthesis of new curcumin-based aminocarbonitrile derivatives incorporating 4H-pyran and 1,4-dihydropyridine heterocycles. Mol Divers 25, 2123–2135 (2021). https://doi.org/10.1007/s11030-020-10104-3

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