Abstract
In an attempt to search for new natural products-based antifungal agents, a series of novel dehydroabietic acid derivatives bearing a 1,3,4-thiadiazole-thiazolidinone moiety were designed and synthesized. The primary bioassay used showed that at a concentration of \(50\,\upmu \hbox {g}/\hbox {mL}\), the target compounds 3c, 3f, and 3n exhibited excellent antifungal activity (91.3 % inhibition) against Gibberella zeae, which was equivalent to the commercial antifungal drug azoxystrobin (positive control).
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Acknowledgments
This study was financially supported by the National Natural Science Foundation of China (No. 31060100) and the Fund of Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization (No.FPRU2016-1). The authors are thankful to the Research Institute of Elemento-organic Chemistry, Nankai University, China, for the bioassay test.
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Chen, N., Duan, W., Lin, G. et al. Synthesis and antifungal activity of dehydroabietic acid-based 1,3,4-thiadiazole-thiazolidinone compounds. Mol Divers 20, 897–905 (2016). https://doi.org/10.1007/s11030-016-9691-x
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DOI: https://doi.org/10.1007/s11030-016-9691-x