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Combining click-multicomponent reaction: one-pot synthesis of triazolyl methoxy-phenyl indazolo[2,1-b]phthalazine-trione derivatives

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Abstract

[(1,2,3-Triazol-4-yl)methoxy-phenyl]-2H-indazolo[2,1-b]phthalazine-trione derivatives were synthesized in a simple and efficient method from the one-pot four-component condensation reaction of phthalhydrazide, aromatic propargyloxy aldehydes, active methylene compounds (dimedone and 1,3-cyclohexanedione), and azides in the presence of Cu(OAc)2/sodium ascorbate and p-toluenesulfonic acid as catalysts in good to excellent yields.

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Authors and Affiliations

  1. Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin, 1983963113, Tehran, Iran

    Peyman Salehi

  2. Department of Chemistry, University of New Brunswick, P.O. Box 4400, Fredericton, NB, E3B 5A3, Canada

    David I. MaGee & Jordan Donahue

  3. Department of Chemistry, Faculty of Science, Shahid Beheshti University, G. C., Evin, 1983963113, Tehran, Iran

    Minoo Dabiri & Laleh Torkian

Authors
  1. Peyman Salehi
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  2. David I. MaGee
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  3. Minoo Dabiri
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  4. Laleh Torkian
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  5. Jordan Donahue
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Correspondence to David I. MaGee.

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Salehi, P., MaGee, D.I., Dabiri, M. et al. Combining click-multicomponent reaction: one-pot synthesis of triazolyl methoxy-phenyl indazolo[2,1-b]phthalazine-trione derivatives. Mol Divers 16, 231–240 (2012). https://doi.org/10.1007/s11030-011-9348-8

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  • DOI: https://doi.org/10.1007/s11030-011-9348-8

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