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The effects of polyvinyl alcohol-coated selenium nanoparticles on memory impairment in rats

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Abstract

Some mineral elements exert beneficial neuroprotection, especially in the form of nanoparticles. The aim of the present study was to evaluate the effects of selenium nanoparticles (SeNPs) and polyvinyl alcohol (PVA)-coated SeNPs (PVA-SeNPs) on Alzheimer’s disease (AD) in a rat model of AD. Twenty-eight rats were randomly divided into four groups of seven rats: control, Alz, Alz + Se, and Alz + Se-PV groups. PVA-SeNPs and SeNPs were chemically synthesized and orally administrated (0.4 mg/kg) to the AD rats for one month. AD was induced by an intracerebroventricular (ICV) injection of streptozotocin (STZ). The memory function was assessed by the novel object recognition (NOR) and passive avoidance learning (PAL) tests. The expression of hippocampal brain-derived neurotrophic factor (BDNF) and stress oxidative markers (MDA and TAC), and the number of amyloid-beta (Aβ) plaques were assessed using ELISA kits, biochemical methods, and Congo red staining, respectively. The results of the behavioral tests showed that the discrimination index in the NOR test increased in the Alz + PVA-SeNPs group compared to the Alz group. Memory performance in the PAL task improved in the PVA-SeNPs and SeNPs groups compared to the Alz group. The level of the BDNF in both of the Alz treatment groups (PVA-SeNPs and SeNPs) showed a significant increase compared to the Alz group. MDA levels and Aβ plaques decreased in both NPs-treated Alz groups, while TAC levels decreased in all Alz groups. PVA-SeNPs were more effective than SeNPs in the improvement of the cognition deficit. The results suggest that PVA-SeNPs improve the cognition and memory deficit induced by an ICV injection of STZ through a decrease in the number of Aβ plaques and malondialdehyde levels and an increase in the BDNF levels.

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Funding

This research was supported by a grant (No. 9808286340) from the Neurophysiology Research Center of the Hamadan Universityof Medical Sciences.

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Authors and Affiliations

  1. Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

    Nasrin Hashemi-Firouzi, Simin Afshar & Siamak Shahidi

  2. Department of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

    Sara Soleimani Asl & Bahareh Gholamigeravand

  3. Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran

    Alireza Samzadeh-Kermani

  4. School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

    Kimia Amiri & Mahsa Majidi

Authors
  1. Nasrin Hashemi-Firouzi
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Contributions

Conceptualization: Nasrin Hashemi-Firouzi, Simin Afshar, Sara Soleimani Asl, Siamak Shahidi; Data curation: Simin Afshar, Alireza Samzadeh-Kermani, Bahareh Gholamigeravand, Kimia Amiri, Mahsa Majidi; Formal analysis: Nasrin Hashemi-Firouzi, Sara Soleimani Asl, Siamak Shahidi; Funding acquisition: Siamak Shahidi; Investigation: Nasrin Hashemi-Firouzi, Simin Afshar, Sara Soleimani Asl, Siamak Shahidi; Methodology: Nasrin Hashemi-Firouzi, Simin Afshar, Sara Soleimani Asl, Alireza Samzadeh-Kermani, Siamak Shahidi; Project administration: Siamak Shahidi; Software: Sara Soleimani Asl; Supervision: Siamak Shahidi; Visualization: Simin Afshar, Sara Soleimani Asl, Alireza Samzadeh-Kermani, Siamak Shahidi; Writing - original draft; Writing - review & editing: Nasrin Hashemi-Firouzi, Sara Soleimani Asl, Siamak Shahidi.

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The Medical Ethics Committee of Hamadan University of Medical Sciences (IR.UMSHA.REC.1398.629) approved all treatment and experimental procedures of the current study. All research and animal care procedures were in accordance with the National Institutes of Health Guide for Care and Use of Laboratory Animals (Publication No. 85–23, revised 1985).

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Hashemi-Firouzi, N., Afshar, S., Asl, S.S. et al. The effects of polyvinyl alcohol-coated selenium nanoparticles on memory impairment in rats. Metab Brain Dis 37, 3011–3021 (2022). https://doi.org/10.1007/s11011-022-01084-4

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