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Development of stem cell therapy for atherosclerosis

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Abstract

Cardiovascular disease (CVD) has a high incidence and low cure rate worldwide, and atherosclerosis (AS) is the main factor inducing cardiovascular disease, of which lipid deposition in the vessel wall is the main marker of AS. Currently, although statins can be used to lower lipids and low-density lipoprotein (LDL) in AS, the cure rate for AS remains low. Therefore, there is an urgent need to develop new therapeutic approaches, and stem cells are now widely studied, while stem cells are a class of cell types that always maintain the ability to differentiate and can differentiate to form other cells and tissues, and stem cell transplantation techniques have shown efficacy in the treatment of other diseases. With the establishment of cellular therapies and continued research in stem cell technology, stem cells are also being used to address the problem of AS. In this paper, we focus on recent research advances in stem cell therapy for AS and briefly summarize the relevant factors that induce the formation of AS. We mainly discuss the efficacy and application prospects of mesenchymal stem cells (MSCs) for the treatment of AS, in addition to the partial role and potential of exosomes in the treatment of AS. Further, provide new ideas for the clinical application of stem cells.

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Funding

This work was supported by the National Key Research and Development Project (2019YFA0801601) and the National Natural Science Foundation of China (81971087).

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  1. Institute of Biochemistry and Molecular Biology, Hengyang Medical College, University of South China, Hengyang, 421001, Hunan, China

    Yun Ma, Tianhe Gu, Siqi He, Shuya He & Zhisheng Jiang

  2. Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hengyang Medical School, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, University of South China, Hengyang, 421001, Hunan, China

    Yun Ma & Zhisheng Jiang

  3. Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China

    Yun Ma

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Ma, Y., Gu, T., He, S. et al. Development of stem cell therapy for atherosclerosis. Mol Cell Biochem 479, 779–791 (2024). https://doi.org/10.1007/s11010-023-04762-8

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  • DOI: https://doi.org/10.1007/s11010-023-04762-8

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