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Adipose-Derived Stem Cell Exosomes and Related microRNAs in Atherosclerotic Cardiovascular Disease

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Abstract

Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of death from noncommunicable diseases worldwide. The pathological development of ASCVD begins with atherosclerosis, followed by the narrowing and occlusion of the vascular lumen and, subsequently, ischemic necrosis in coronary arteries. Preventing atherosclerosis development and delaying ischemia progression may be effective ways of pre-diagnosing and treating ASCVD. Studies have demonstrated that exosomes from adipose-derived stem cells play an increasingly important role in basic research on cardiovascular diseases in terms of the impact of macrophage polarization and the endothelial, anti-apoptosis, and angiogenesis effects. The related microRNAs play a significant role in ASCVD. This study was novel in reviewing the role of exosomes from adipose-derived stem cells and related microRNAs in ASCVD.

Graphical abstract

Therapeutic potentials of adipose-derived stem cell exosomes in terms of their impact on macrophage polarization, endothelial effect, anti-apoptosis intervention, and angiogenesis

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Abbreviations

ASCVD:

Atherosclerotic cardiovascular disease

AS:

Atherosclerosis

MI:

Myocardial infarction

ASCs:

Adipose-derived stem cells

MSCs:

mesenchymal stem cells

miRNAs:

microRNAs

AMI:

acute myocardial infarction

ECs:

endothelial cells

I/R:

ischemia/reperfusion

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Acknowledgements

The authors appreciate the language edit service from Medsci. Fan Zhou and Ke Li contribute to this work equally.

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  1. Department of Cardiology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, 434023, China

    Fan Zhou, Ke Li & Keping Yang

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  1. Fan Zhou
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Correspondence to Keping Yang.

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Zhou, F., Li, K. & Yang, K. Adipose-Derived Stem Cell Exosomes and Related microRNAs in Atherosclerotic Cardiovascular Disease. J. of Cardiovasc. Trans. Res. 16, 453–462 (2023). https://doi.org/10.1007/s12265-022-10329-7

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