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Upregulated TRIM32 correlates with enhanced cell proliferation and poor prognosis in hepatocellular carcinoma

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Abstract

Hepatocellular carcinoma (HCC) is a major type of primary liver cancer and the sixth most prevalent human malignancies worldwide. However, the molecular mechanisms underlying hepatocarcinogenesis remain unclear. For HCC patients, there is not only a lack of effective therapeutic targets but also a lack of predictive or prognostic biomarkers. In this article, we reported that TRIM32 was obviously upregulated in HCC tumor tissues and HCC cell lines. Its expression patterns were positively correlated with histological grade, tumor sizes, and HBsAg of HCC patients. TRIM32 expression was a significant predictor for the overall survival time of HCC patients. Moreover, the overexpression of TRIM32 in cells accelerated the G1-S phase transition, promoted cell proliferation rates, and induced the resistance of HCC patients to oxaliplatin. All these findings suggest that TRIM32 might play important roles in the hepatocarcinogenesis. TRIM32 could be a novel direction to explore the mechanism underlying HCC pathogenesis.

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Funding

This study was funded by the Natural Youth Foundation of China (Grant numbers 81502072, 81401985), National Natural Science Foundation of China (Grant number 81472272), The Administration of Science and Technology of Nantong (Grant number MS22015062).

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    Authors and Affiliations

    1. Department of General Surgery, Affiliated Hospital of Nantong University, Medical College of Nantong University, Nantong, 226001, Jiangsu, People’s Republic of China

      Xiaopeng Cui

    2. Department of Gastroenterology, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, People’s Republic of China

      Zhipeng Lin, Wenkai Ni, Jinxia Liu, Xiaohang Shan, Lingling Chen, Jiale Lv, Zhongyi Shen & Runzhou Ni

    3. Class 5 Grade 13, Clinical Medicine, Medical College, Nantong University, Nantong, 226001, Jiangsu, People’s Republic of China

      Yuyan Chen

    4. Department of Stomatology, The First Affiliated Hospital of Dalian Medical University, Dalian, 116000, Liaoning, People’s Republic of China

      Xiaofei Mao

    5. Key Laboratory of Neuroregeneration, Nantong University, Nantong, 226001, Jiangsu, People’s Republic of China

      Huiling Zhou

    6. The Second Peoples’ Hospital of Nantong, Nantong, 226001, Jiangsu, People’s Republic of China

      Chengwei Duan

    7. Basic Medical Research Centre, Medical College, Nantong University, Nantong, 226001, Jiangsu, People’s Republic of China

      Baoying Hu

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    1. Xiaopeng Cui
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    Correspondence to Baoying Hu or Runzhou Ni.

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    Xiaopeng Cui and Zhipeng Lin equally contributed to this work.

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    Cui, X., Lin, Z., Chen, Y. et al. Upregulated TRIM32 correlates with enhanced cell proliferation and poor prognosis in hepatocellular carcinoma. Mol Cell Biochem 421, 127–137 (2016). https://doi.org/10.1007/s11010-016-2793-z

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