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miR-96 downregulates RECK to promote growth and motility of non-small cell lung cancer cells

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Abstract

MicroRNAs play critical roles in the development and progression of non-small cell lung cancer (NSCLC). miR-96 acts as an oncogene in some malignancies, while its role in NSCLC is unclear. Here, we validated that miR-96 was significantly increased in both human NSCLC tissues and cell lines. Inhibition of miR-96 expression remarkably reduced cell proliferation, colony formation, migration, and invasion of NSCLC cells. Reversion-inducing-cysteine-rich protein with kazal motifs (RECK) was identified as a target of miR-96 in NSCLC cells. In addition, the expression of RECK was found to be negatively correlated with the expression of miR-96 in NSCLC tissues. Our data suggest that miR-96 might promote the growth and motility of NSCLC cells partially by targeting RECK.

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Authors and Affiliations

  1. Department of thoracic surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China

    Haizhou Guo, Weihao Li, Tianliang Zheng & Song Zhao

  2. Department of Cardiothoracic Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, 200233, China

    Qianping Li

  3. Institute of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China

    Zhangsuo Liu

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  1. Haizhou Guo
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  2. Qianping Li
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  3. Weihao Li
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  4. Tianliang Zheng
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  5. Song Zhao
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  6. Zhangsuo Liu
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Correspondence to Zhangsuo Liu.

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Haizhou Guo and Qianping Li have contributed equally to this work.

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Guo, H., Li, Q., Li, W. et al. miR-96 downregulates RECK to promote growth and motility of non-small cell lung cancer cells. Mol Cell Biochem 390, 155–160 (2014). https://doi.org/10.1007/s11010-014-1966-x

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  • DOI: https://doi.org/10.1007/s11010-014-1966-x

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