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Gastrointestinal tract specific gene GDDR inhibits the progression of gastric cancer in a TFF1 dependent manner

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Abstract

The novel gene GDDR, also named trefoil factor interactions 1, is abundantly expressed in human gastric epithelial cells but significantly down-regulated in gastric cancer. In this study, we first demonstrated that GDDR was specifically expressed in the gastrointestinal tract epithelium, while suppressed in gastric cancer cells. Forced expression of GDDR suppressed the tumor growth as shown by MTT and xenograft assay. siRNA mediated TFF1 inhibition nearly blocked the growth inhibitory role of GDDR. In summary, our study suggested that gastrointestinal tract specific gene GDDR might inhibit gastric cancer growth in a TFF1 dependent manner.

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Acknowledgment

This study was funded by National Science Foundation of China NSFC: No.30471698.

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Authors and Affiliations

  1. Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Changlexi Road No. 15th, Xi’an, 710032, China

    Guanghui Chu, Shengbin Qi & Jianjun Du

  2. Department of Biochemistry and Molecular Biology, The State Key Lab of Cancer Biology, The Fourth Military Medical University, Changlexi Road No. 17th, Xi’an, 710032, China

    Guodong Yang & Zifan Lu

  3. Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, China

    Kefeng Dou

Authors
  1. Guanghui Chu
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  2. Shengbin Qi
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  3. Guodong Yang
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  4. Kefeng Dou
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  5. Jianjun Du
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  6. Zifan Lu
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Correspondence to Jianjun Du or Zifan Lu.

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Guanghui Chu and Shengbin Qi are co-first authors.

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Chu, G., Qi, S., Yang, G. et al. Gastrointestinal tract specific gene GDDR inhibits the progression of gastric cancer in a TFF1 dependent manner. Mol Cell Biochem 359, 369–374 (2012). https://doi.org/10.1007/s11010-011-1030-z

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  • DOI: https://doi.org/10.1007/s11010-011-1030-z

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