Abstract
In recent years management scholars and practitioners have been interested in Research and Development (R&D) partnering, especially in high-tech industries. While the motivations of research partnership formation have been widely explored in literature, little attempt has been undertaken to examine the effects of research partnerships on R&D productivity and the implications for business models of the new ventures. In this paper we try to shed some light on the business models of the young ventures involved in R&D partnerships and their effect on R&D productivity. Our hypotheses are that experience in previous alliances, repeated partnerships and tight relationships have positive effects on R&D productivity while rigid governance structures and public R&D subsidies have negative effects on such productivity. We discuss how these aspects affect the business models of biotech firms. We test our hypotheses on a sample of 55 Italian DBFs (Dedicated Biotech Firms). Results support our hypotheses. Managerial implications and further issues for future research are discussed.
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References
Aghion, P., & Tirole, J. (1994). On the management of innovation. Quarterly Journal of Economics, 109(4), 1185–1207.
Ahuja, G. (2000). The duality of collaboration: Inducements and opportunities in the formation of interfirm linkages. Strategic Management Journal, 21(3), 317–343.
Almus, M., & Czarnitzky, D. (2003). The effect of public R&D subsidies on firms’innovation activities: The case of eastern germany. Journal of Business and Economic Statistics, 21(2), 226–236.
Anand, B. N., & Khanna, T. (2000). Do firms learn to create value? The case of alliance. Strategic Management Journal, 21, 295–315.
Arora, A., & Gambardella, A. (1990). Complementarity and external linkages: The strategies of the large firms in biotechnology. Journal of Industrial Economics, 38, 361–379.
Audretsch, D. B., & Feldman, M. P. (2003). Small-Firm strategic research partnerships: The case of biotechnology. Technology Analysis & Strategic Management, 15(2), 273–288.
Barney, J. B. (1991). Firm resources and sustained competitive advantage. Journal of Management, 17(1), 99–120.
Barney, J. B., & Hansen, M. H. (1994). Trustworthiness as a source of competitive advantage. Strategic Management Journal, 15, 175–190.
Baum, J. A. C., Calabrese, T., & Silverman, B. S. (2000). Don’t go it alone: Alliance network composition and startups’ performance in Canadian biotechnology. Strategic Management Journal, 21(3), 267–294.
Berkovitz, J. E. L., & Feldman, M. P. (2007). Fishing upstream: Firm innovation strategy and university research alliances. Research Policy, 36, 930–948.
Bigliardi, B., Nosella, A., & Verbano, A. (2005). Business model in Italian biotechnology industry: a quantitative analysis. Technovation, 25(11), 1299–1306.
Biopolo (2008). Italian biotechnology directory. Facts&Trends analysis. Report 2008. Resource document Biopolo.
Bleeke, J., & Ernst, D. (1991). The way to win in cross border alliances. Harvard Business Review, 69(6), 127–135.
Blossom (2008). Biotecnologie in Italia. Analisi Strategica e Finanziaria. Rapporto Blossom Associati-Assobiotec. http://www.farmindustria.it/pubblico/Rapporto_Blossom.pdf.
Blossom (2009). Biotecnologie in Italia. Analisi Strategica e Finanziaria. Rapporto Blossom Associati-Assobiotec.
Busom, I. (2000). An empirical evaluation of the effects of R&D subsidies. Economics of Innovation and New Technology, 9, 111–148.
Cohen, P., Cohen, J., West, S. G., & Aiken, L. S. (2003). Applied multiple regression/correlation analysis for the behavioural sciences (3rd ed.). Erlbaum: Hillsdale.
Cunningham, B. C. (2002). Biotech and pharma: State of the relationship in the new millennium. Drug Development Research, 57, 97–102.
Dacin, M. T., Hitt, M. A., & Levitas, E. (1997). Selecting partners for successful international alliances: Examination of US and Korean firms. Journal of World Business, 32(1), 3–16.
Danzon, P. M., Nicholson, S., & Pereira, N. S. (2005). Productivity in pharmaceutical-biotechnology R&D: The role of experience and alliances. Journal of Health Economics, 24, 317–339.
Das, T. K., & Teng, B. (1998). Between trust and control: Developing confidence in partner cooperation in alliances. Academy of Management Review, 23(3), 491–512.
Datamonitor. (2006). Biotechnology in Italy. Industry profile. London: Datamonitor Europe.
De Carolis, D. M., & Deeds, D. L. (1999). The impact of stocks and flows of organizational knowledge on firm performance: An empirical investigation of the biotechnology industry. Strategic Management Journal, 20, 953–968.
Deeds, D. L., & Hill, C. W. L. (1996). Strategic alliances and the rate of new product development: An empirical study of entrepreneurial biotechnology firms. Journal of Business Venturing, 11, 41–55.
Deeds, D. L., DeCarolis, D. M., & Coombs, J. (2000). Dynamics capabilities and new product development in high technology ventures: An empirical analysis of new biotechnology firms. Journal of Business Venturing, 15, 211–229.
Duysters, G. (1996). The dynamics of technical innovation: The evolution and development of information technology. Chelternham: Edward Elgar.
Duysters, G. G., Kok, G., & Vaandrager, M. (1999). Crafting successful strategic technology partnerships. R&D Management, 29(4), 343–351.
Dyer, J., & Singh, H. (1998). The relational view: Cooperative strategies and sources of interorganizational competitive advantage. Academy of Management Review, 23(4), 660–679.
Eisenhardt, K. M., & Martin, J. A. (2000). Dynamics capabilities: What are they? Strategic Management Journal, 21, 1105–1121.
Ernst & Young (2006) Beyond borders. Global Biotechnology Report. Global Biotechnology Center.
Ernst & Young (2008) Beyond borders. Annual Global Biotechnology Report. Global Biotechnology Center.
Freeman, J. G. R., Carroll, R., & Hannan, M. T. (1983). The liability of newness: Age dependence in organizational death rates. American Sociological Review, 48, 692–710.
Gadde, L. E., Huemer, L., & Hakansson, H. (2003). Strategizing in industrial networks. Industrial Marketing Management, 32, 357–364.
Gambardella, A. (1990). Science and Innovation: The US Pharmaceutical Industry During the 1980s. Cambridge: Cambridge University Press.
Gans, J. S., & Stern, S. (2003). The product market and the market for “ideas”: Commercialization strategies for technology entrepreneurs. Research Policy, 32, 333–350.
Goerzen, A. (2007). Alliance network and firm performance: The impact of repeated ties. Strategic Management Journal, 28, 487–509.
Gomes-Casseres, B. (1996). The alliance revolution: The new shape of business rivalry. Cambridge: Harvard University Press.
Griliches, Z. (1986). Productivity, R&D and Basic Research at the Firm Level in the 1970’s. American Economic Review, 76(1), 41–154.
Grossman, S., & Hart, O. (1986). The costs and the benefits of ownership: A theory of vertical and lateral integration. Journal of Political Economy, 94, 691–719.
Gulati, R. (1998). Alliances and networks. Strategic Management Journal, 19, 293–317.
Gulati, R., Nohria, N., & Zaheer, A. (2000). Strategic networks. Strategic Management Journal, 21(3), 203–215.
Hagedoorn, J. (1993). Understanding the rational of strategic technology partnering: interorganizational modes of cooperation and sectoral differences. Strategic Management Journal, 14(5), 371–385.
Hagedoorn, J. (1996). Trends and Patterns in strategic technology partnering since the early seventies. Review of Industrial Organization, 11, 601–616.
Hagedoorn, J., & Schakenraad, J. (1990). Strategic partnering and technological co-operation. In B. Dankbaar, et al. (Eds.), Perspectives in industrial economics. Dordrecht: Kluwer.
Hagedoorn, J., & Schakenraad, J. (1992). Leading companies and networks of strategic alliances in information technologies. Research Policy, 21, 163–190.
Hagedoorn, J., Link, A. N., & Vonortas, N. S. (2000). Research partnerships. Research Policy, 29, 567–586.
Hagedoorn, J., Lorenz-Orlean, S., & Kranenburg, H. (2006). Inter-firm technology transfer: Partnership-embedded licensing or standard licensing agreement? Working Paper Series.
Hamel, G., Doz, Y., & Prahalad, C. K. (1989). Collaborate with your competitors and win. Harvard Business Review, 67(1), 133–139.
Harrigan, K. R. (1985). Strategies for Joint Ventures. Lexington: Lexington Books.
Hill, C. W. L., & Rothaermel, F. T. (2003). The performance of incumbent firms in the face of radical technological innovation. Academy of Management Review, 28, 257–274.
Hoang, H., & Rothaermel, F. T. (2005). The effect of general and partner-specific alliance experience on joint R&D project performance. Academy of Management Journal, 48(2), 332–345.
Hopkins, M. M., et al. (2007). The myth of the biotech revolution: An assessment of technological, clinical and organisational change. Research Policy, 36, 566–589.
Huber, G., & Daft, R. (1987). The information environment of organizations. In F. Jablin, et al. (Eds.), Handbook of Organizational Communication. Newbury Park: Sage.
Hwang, Y., & Park, S. H. (2007). The organizational life cycle as a determinant of strategic alliance tactics: Research propositions. International Journal of Management, 24(3), 427–435.
Inkpen, A. C., & Ross, J. (2001). Why do some strategic alliances persist beyond their useful life? California Management Review, 44(1), 132–148.
Ipi. (2007). Il settore delle biotecnologie in Italia. Roma: Un quadro conoscitivo degli operatori e dei programmi di sostegno.
Jablin, F., Putnam, L., Roberts, K., & Porter, L. (1987). Handbook of Organizational Communication. Newbury Park: Sage.
Kale, P., & Singh, H. (2007). Building firm capabilities through learning: The role of the alliance learning process in alliance capability and firm level alliance success. Strategic Management Journal, 28, 981–1000.
Kanter, R. M. (1989). When Giants Learn to Dance. New York: Simon & Schuster.
Khanna, T., Gulati, R., & Nohria, N. (1998). The dynamics of learning alliances: Competition, cooperation and relative scope. Strategic Management Journal, 19(3), 193–210.
Kleinbaum, D. G., Kupper, L. L., Muller, K. E., & Nizam, A. (2007). Applied Regression Analysis and Multivariable Methods 4 th Edition. Boston: Duxbury Press.
Klette, T. J., Moen, J., & Griliches, Z. (2000). Do subsidies to commercial R&D reduce market failures? Microeconometric evaluation studies. Research Policy, 29, 471–495.
Kogut, B. (1989). The stability of joint ventures: reciprocity and competitive rivalry. Journal of Industrial Economics, 38, 183–198.
Lacetera, N. (2001). Corporate governance and the governance of innovation: the case of pharmaceutical industry. Journal of Management and Governance, 5(1), 29–59.
Lawton-Smith, H., Dickson, K., & Smith, S. L. (1991). There are two sides to every story: Innovation and collaboration within networks of large and small firms. Research Policy, 20, 457–468.
Lechner, C., & Dowling, M. (1999). The evolution of industrial districts and regional networks: The case of the biotechnology region munich/martinsried. Journal of Management and Governance, 3(4), 309–338.
Leifer, R., & Mills, P. K. (1996). An information processing approach for deciding upon control strategies and reducing control loss in emerging organizations. Journal of Management, 22, 113–137.
Lerner, J., & Merges, R. P. (1998). The control of technological alliances: An empirical analysis of the biotechnology industry. Journal of Industrial Economics, 46(2), 125–156.
Levitt, B., & March, J. G. (1988). Organizational learning. In W.R. Scott (Ed.), Annual review of sociology (pp. 319-340). Greenwich: JAI Press.
Link, A. N. (1998a). A case study of R&D efficiency in ATP joint ventures. Journal of Technology Transfer, 23, 43–52.
Link, A. N. (1998b). The U.S. display consortium: an analysis of a public/private partnership. Industry and Innovation, 5, 35–50.
Lyles, M. (1988). Learning among joint venture sophisticated firms. In F. Contractor & P. Lorange (Eds.), Cooperative strategies in international business (pp. 301–316). Lexington: Lexington Books.
Maggioni, V., Sorrentino, M., & Williams, M. (1999). Mixed consequences of government aid for new ventures. Journal of Management and Governance, 3(3), 287–305.
March, J. G. (1991). Exploration and exploitation is organizational learning. Organization Science, 2, 71–87.
Miles, R. E., Miles, G., & Snow, C. C. (2006). Collaborative entrepreneurship: A business model for continuous innovation. Organizational Dynamics, 35, 1–11.
Miotti, L., & Sachwald, F. (2003). Co-operative R&D: why and with whom? An integrated framework of analysis. Research Policy, 32, 1481–1499.
Mohr, J., & Spekman, R. (1994). Characteristics of partnership success: partnership attributes, communication behaviour, and conflict resolution techniques. Strategic Management Journal, 15, 135–152.
Mowery, D. C., & Rosenberg, N. (1989). Technology and the pursuit of economic growth. Cambridge: Cambridge University Press.
Niosi, J. (2003). Alliances are not enough explaining rapid growth in biotechnology firms. Research Policy, 32, 737–750.
Onetti, A., Versaggi, C. S., & Mackler, B. F. (2009). Italian biotech revamps old-world mindset. Casting off traditional business customs expected to push the industry forward. Genetic Engineering & Biotechnology News (GEN), 29(14), 60.
Onetti, A., Zucchella, A., Jones, M. V., & McDougall-Covin, P. P. (2010). Internationalization, innovation and entrepreneurship: Business models for new technology-based firms. Journal of Management and Governance. doi:10.1007/s10997-010-9154-1.
Orsenigo, L. (2001). The (failed) development of a biotechnology cluster: The case of lombardy. Small Business Economics, 17, 77–92.
Orsenigo, L., Pammolli, F., Riccaboni, M., Bonaccorsi, A., & Turchetti, G. (1998). The evolution of knowledge and the dynamics of an industry network. Journal of Management and Governance, 1(2), 147–175.
Patel, P., Arundel, A., & Hopkins, M. (2008). Sectoral innovation systems in Europe: Monitoring, analysing trends and identifying challenges in biotechnology. Europe Innova, Final Report, Bruxelles, European Commission.
Penrose, E. T. (1959). The theory of the growth of the firm. New York: ME Sharpe.
Peteraf, M. A. (1993). The cornerstones of competitive advantage: A resource-based view. Strategic Management Journal, 14(3), 179–191.
Pisano, G. P. (1990). The R&D boundaries of the firm: An empirical analysis. Administrative Science Quarterly, 35(1), 153–176.
Pisano, G. P. (2006). Science business: The promise, reality and future of biotech. Cambridge: Harvard Business School Press.
Powell, W. W. (1998). Learning from collaboration: Knowledge networks in biotechnology and pharmaceutical industries. California Management Review, 40(3), 228–240.
Powell, W. W., Koput, K. W., & Smith-Doerr, L. (1996). Inter-organizational collaboration and the locus of innovation: Networks of learning in biotechnology. Administrative Science Quarterly, 41, 116–145.
Recap (2009). Analyst’s Notebook–Trends in Big Ticket Alliances ($ + 100 M) 1998–2007. Resource document. Recap.
Roijakkers, N., & Hagedoorn, J. (2006). Inter-firm R&D partnering in pharmaceutical biotechnology since 1975: Trends, patterns, and networks. Research Policy, 35, 431–446.
Roijakkers, N., Hagedoorn, J., & van Kranenburg, H. (2005). Dual market structures and the likelihood of repeated ties–evidence from pharmaceutical biotechnology. Research Policy, 34, 235–245.
Rothaermel, F. T., & Boeker, W. (2008). Old technology meets new technology. Strategic Management Journal, 29, 47–77.
Rothaermel, F. T., & Deeds, D. L. (2004). Exploration and Exploitation alliances in biotechnology: a system of new product development. Strategic Management Journal, 25, 201–221.
Saxton, T. (1997). The effects of partner and relationship characteristics on alliance outcomes. Academy of Management Journal, 40(2), 443–461.
Shan, W., Walker, G., & Kogut, B. (1994). Inter-firm cooperation and start-up innovation in the biotechnology industry. Strategic Management Journal, 15(5), 387–394.
Stinchcombe, A. L. (1965). Social structure and organizations. In J. G. March (Ed.), Handbook of organizations. Chicago: Rand McNally.
Stuart, T. E., Hoang, H., & Hybels, R. C. (1999). Interorganizational endorsements and the performance of entrepreneurial ventures. Administrative Science Quarterly, 44, 315–349.
Stuart, T. E., Ozdemir, S. Z., & Ding, W. W. (2007). Vertical alliance networks: The case of university-biotechnology-pharmaceutical alliance chains. Research Policy, 36, 477–498.
Teece, D. J. (1992). Competition, cooperation and innovation: Organizational arrangements for regimes of rapid technological progress. Journal of Economic Behaviour and Organization, 18, 1–25.
Wernerfelt, B. (1984). A resource-based view of the firm. Strategic Management Journal, 5, 171–180.
Acknowledgments
The authors would like to express their gratitude to Professor Ian C. MacMillan and Professor Donna M. De Carolis for their helpful comments on a previous draft of the paper. We would also like to thank the editor and the two anonymous reviewers for their insightful and valuable comments and suggestions.
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Sorrentino, F., Garraffo, F. Explaining performing R&D through alliances: Implications for the business model of Italian dedicated biotech firms. J Manag Gov 16, 449–475 (2012). https://doi.org/10.1007/s10997-010-9159-9
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DOI: https://doi.org/10.1007/s10997-010-9159-9