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Investigation of the thermal stability of the antihypertensive drug nebivolol under different conditions: Experimental and computational analysis

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Abstract

The thermal decomposition of the third-generation beta-blocker nebivolol (NEB) was investigated using thermogravimetric analysis (TG) under isothermal and non-isothermal environments, revealing important steadiness performance for the dispensation in the pharma manufacturing, expecting shelf life, and appropriate storing features. Kinetic analysis was carried out using Kissinger–Akahira–Sunose, Friedman, Flynn–Wall–Ozawa, and Starink methods. The analysis reveals that the activation energy estimated from the disintegration reactions via different techniques is unswerving with each other. Furthermore, the thermodynamic constraints (ΔH, ΔS, and ΔG) of the decomposition reaction were also estimated. A correlation between the mass spectrometry and thermal behavior of NEB has also been investigated. The study provides valuable stability data, expected shelf life, and optimal storing conditions that would help drug design and manufacturing. Density functional theory was also employed to study the possible thermodynamic dissociation channels of NEB.

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Authors and Affiliations

  1. Deanship of the Common First Year, Al-Jouf University, Al-Jouf, Saudi Arabia

    Aml M. Asran

  2. Faculty of Engineering, Modern Academy for Technology and Engineering, Cairo, Egypt

    Aml M. Asran

  3. Pharmaceutical Chemistry Department, National Organization for Drug Control and Research (NODCAR), Egyptian Drug Authority, Giza, Egypt

    Mona A. Mohamed & Ghada M. G. Eldin

  4. Energy Materials Laboratory, School of Sciences and Engineering, The American University, Cairo, 11835, New Cairo, Egypt

    Mona A. Mohamed, Ghada E. Khedr & Nageh K. Allam

  5. Department of Analysis and Evaluation, Egyptian Petroleum Research Institute, Cairo, 11727, Egypt

    Ghada E. Khedr

  6. Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt

    Ali M. Yehia

  7. School of Life and Medical Sciences, University of Hertfordshire Hosted By Global Academic Foundation, New Capital, Garden City, Cairo, R5 New, Egypt

    Ali M. Yehia

  8. Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur, 303002, India

    Rupesh K. Mishra

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  1. Aml M. Asran
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Asran, A.M., Mohamed, M.A., Khedr, G.E. et al. Investigation of the thermal stability of the antihypertensive drug nebivolol under different conditions: Experimental and computational analysis. J Therm Anal Calorim 147, 5779–5786 (2022). https://doi.org/10.1007/s10973-021-10893-1

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