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Physico-chemical study of norfloxacin and metronidazole binary mixtures

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Abstract

The physico-chemical characterization of norfloxacin commercial sample (NF), norfloxacin anhydrous form A (NFanhA), norfloxacin pentahydrate (NF·5H2O) and metronidazole (MZ) has been carried out. It was determined that the commercial sample is a mixture of 74% anhydrous NF form A and 26% hemipentahydrate NF. From XRPD analysis, it was observed that after the water loss, NF·5H2O undergoes a solid–solid transition and is converting to NFanhA. Solid–liquid equilibrium for NFanhA–MZ and NF·5H2O–MZ binary systems has been investigated using differential scanning calorimetry, and simple eutectic point was observed, in good approximation, at 419 K for all the mixtures studied. The experimental solid–liquid phase diagram was compared with predictions obtained from available eutectic equilibrium models. The results indicate non-ideality for the mixture. The mixing enthalpy was determined at the eutectic composition and the negative value obtained, ΔMH = − 13.28 kJ mol−1, indicates that molecules of the two components form clusters in the eutectic melt.

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Acknowledgements

This work was possible with the financial support of the Sectoral Operational Programme for Human Resources Development 2007–2013, co-financed by the European Social Fund, under the Project Number POSDRU/107/1.5/S/80765.

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Authors and Affiliations

  1. Department of Physical Chemistry, Faculty of Chemistry, University of Bucharest, Bd. Regina Elisabeta 4-12, 030018, Bucharest, Romania

    Daniela-Crina Salceanu, Elena Pincu & Viorica Meltzer

  2. Department of Chemistry, Section of Physical Chemistry, C.S.G.I, University of Pavia, Viale Taramelli 16, 27100, Pavia, Italy

    Giovanna Bruni & Amedeo Marini

Authors
  1. Daniela-Crina Salceanu
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  2. Elena Pincu
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Correspondence to Viorica Meltzer.

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Salceanu, DC., Pincu, E., Bruni, G. et al. Physico-chemical study of norfloxacin and metronidazole binary mixtures. J Therm Anal Calorim 132, 1095–1103 (2018). https://doi.org/10.1007/s10973-017-6919-7

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  • DOI: https://doi.org/10.1007/s10973-017-6919-7

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