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Development of thermogravimetric method for quantitative determination of metronidazole

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Abstract

The objective of this work was to develop and validate a fast and reproducible method to determine the concentration of metronidazole in drug substance and tablets. The samples were analyzed by dynamic thermogravimetry, using 10, 20, 40, 60 and 80°C min–1 heating rates in nitrogen and in nitrogen with synthetic air. Obtained data were used in the Antoine and Langmuir equations in order to have the pressure curves. Vapor pressure curves of drug and tablet of metronidazole were evaluated using the mathematical indexes of difference factor, f 1, and similarity factor, f 2, to compare their profiles. The data showed that there is no significant difference between the vapor pressure profiles of drug and tablet of metronidazole in both environmental conditions, which confirms that the process is really vaporization. The concentration of metronidazole was determined in the raw material and tablets of the drug.

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Authors and Affiliations

  1. Unified Development and Medicine Assays Laboratories – LUDEM, Federal University of Paraíba – UFPB, João Pessoa, Brasil, 58051-970, Cidade Universitária, Campus I – CCS, Paraíba

    Ana Paula Barrêto Gomes, Lidiane Pinto Correia, Mônica Oliveira da Silva Simões & R. O. Macêdo

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  1. Ana Paula Barrêto Gomes
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  2. Lidiane Pinto Correia
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  3. Mônica Oliveira da Silva Simões
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  4. R. O. Macêdo
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Correspondence to Ana Paula Barrêto Gomes.

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Gomes, A.P.B., Correia, L.P., da Silva Simões, M.O. et al. Development of thermogravimetric method for quantitative determination of metronidazole. J Therm Anal Calorim 88, 383–387 (2007). https://doi.org/10.1007/s10973-006-8007-2

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  • DOI: https://doi.org/10.1007/s10973-006-8007-2

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