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Pharmaceutical approaches involving carvedilol characterization, compatibility with different excipients and kinetic studies

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Abstract

This study was performed to investigate the physical–chemical characteristics of carvedilol (CRV), complemented by compatibility studies with a great variety of pharmaceutical excipients. Thermogravimetry and differential scanning calorimetry, supported by diffuse reflectance infrared fourier transform spectroscopy (DRIFT), X-ray powder diffraction, and scanning electron microscopy (SEM) were selected as the solid-state techniques for the intended analyses. In addition, non-isothermal methods were employed to investigate kinetic data of CRV decomposition process under nitrogen and air atmospheres. CRV is characterized by an endothermic sharp event (T peak = 389.81 K and ΔH fusion of −176.28 J g−1) and a thermal decomposition behavior in two stages, totalizing 98 % of mass loss. The CRV pattern diffraction presents prominent peaks at 2θ: 5.92°, 14.90°, 18.62°, 24.47°, and 26.30°, and the DRIFT spectrum showed the main characteristics bands for CRV chemical functional groups. The SEM photomicrographs demonstrate that CRV is characterized by irregular blocky shaped crystals. Zero order kinetics was determined by Ozawa method in both nitrogen and air atmospheres. The compatibility results showed no evidence of any incompatibility among CRV and all the excipients analyzed.

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Acknowledgements

The authors wish to thanks for Cambridge for the information available at Cambridge Structural Database (CSD), Prof. Dr. Adailton João Bortoluzzi of Bioorganic and Crystallographic Laboratory (LABINC)—at Federal University of Santa Catarina. The X-ray measurements were performed at X-ray Diffraction Laboratory (LDRX) at Federal University of Santa Catarina.

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Authors and Affiliations

  1. Quality Control Laboratory, Department of Pharmaceutical Sciences, Health Science Centre, Federal University of Santa Catarina, Florianópolis, SC, 88040-900, Brazil

    Paola Aline Amarante Borba, Manoela Klüppel Riekes, Rafael Nicolay Pereira, Monika Piazzon Tagliari, Marcos Antonio Segatto Silva, Silvia Lucia Cuffini & Hellen Karine Stulzer

  2. Department of Pharmaceutical Sciences, State University of Ponta Grossa, Ponta Grossa, PR, Brazil

    Debora Dalla Vecchia

  3. Post Graduation in Physics, Federal University of Santa Catarina, Florianópolis, SC, Brazil

    Carlos Eduardo Maduro de Campos

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  1. Paola Aline Amarante Borba
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  2. Debora Dalla Vecchia
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  3. Manoela Klüppel Riekes
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Correspondence to Hellen Karine Stulzer.

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Borba, P.A.A., Vecchia, D.D., Riekes, M.K. et al. Pharmaceutical approaches involving carvedilol characterization, compatibility with different excipients and kinetic studies. J Therm Anal Calorim 115, 2507–2515 (2014). https://doi.org/10.1007/s10973-014-3640-7

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  • DOI: https://doi.org/10.1007/s10973-014-3640-7

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