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Differential scanning calorimetry study of blood serum in chronic obstructive pulmonary disease

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Abstract

Differential scanning calorimetry (DSC) has been applied for studies of blood serum from patients sick with chronic obstructive pulmonary disease (COPD). The denaturation of serum proceeds as endothermic process over the temperature range 45–85 °C. Distinct changes in the shape of DSC curves have been observed for serum from patients with severe stage of COPD (treated with inhaled corticosteroids) relative to serum from healthy individuals. The first moment of the thermal transition with respect to the temperature axis shifts from the normal value of 63.9 ± 0.3 to 65.3 ± 0.7 °C and to 67.6 ± 1.6 °C for early and advanced stages of disease, respectively. The results of our studies suggest age dependence of blood serum denaturation transition.

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Authors and Affiliations

  1. Department of Medical Physics, A. Chełkowski Institute of Physics, University of Silesia, ul. Uniwerytecka 4, 40-007, Katowice, Poland

    A. Michnik, Z. Drzazga & K. Michalik

  2. Department of Pneumology, Medical University of Silesia, ul. Medyków 14, 40-752, Katowice, Poland

    A. Barczyk, I. Santura, E. Sozańska & W. Pierzchała

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  1. A. Michnik
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  2. Z. Drzazga
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  3. K. Michalik
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  4. A. Barczyk
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  5. I. Santura
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  6. E. Sozańska
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  7. W. Pierzchała
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Correspondence to A. Michnik.

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Michnik, A., Drzazga, Z., Michalik, K. et al. Differential scanning calorimetry study of blood serum in chronic obstructive pulmonary disease. J Therm Anal Calorim 102, 57–60 (2010). https://doi.org/10.1007/s10973-009-0602-6

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  • DOI: https://doi.org/10.1007/s10973-009-0602-6

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