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Differential scanning calorimetric examination of transverse carpal ligament in carpal tunnel disease

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Abstract

The carpal tunnel syndrome - compression of the median nerve by the transverse ligament of the wrist - is a serious disease of the human hand. The electrophysiological changes in the median nerve can be easily followed by electroneurography (ENG). The degenerative changes in the collagen structures of the carpal ligament cause shrinking of the ligament and compression of the nerve.

According to the present study we could demonstrate that DSC is a useful and well applicable method for the investigation of collagen tissue of the human carpal transverse ligament. DSC scans clearly demonstrated significant differences between the different types and conditions of samples (control: T m=61.3°C and ΔHcal=4.04 J g−1, mild: Tm=62°C and ΔH cal=4.3 J g−1, middle: T m=61.5°C and ΔHcal=5.17 J g−1 as well as severe: T m=61.85°C and ΔH cal=8.44 J g−1). After these investigations we can choose the optimal time of surgical therapy of different clinical level carpal tunnel syndrome too.

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Authors and Affiliations

  1. Department of Traumatology, University of Pécs, Faculty of Medicine, 7624, Pécs, Szigeti str. 12, Hungary

    N. Wiegand, L. Vámhidy, B. Patczai & E. Dömse

  2. Department of Orthopaedics, University of Pécs, Faculty of Medicine, 7624, Pécs, Szigeti str. 12, Hungary

    P. Than

  3. Department of Pathology, University of Pécs, Faculty of Medicine, 7624, Pécs, Szigeti str. 12, Hungary

    L. Kereskai

  4. Department of Biophysics, University of Pécs, Faculty of Medicine, 7624, Pécs, Szigeti str. 12, Hungary

    D. Lőrinczy

Authors
  1. N. Wiegand
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  2. L. Vámhidy
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  3. B. Patczai
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  4. E. Dömse
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  5. P. Than
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  6. L. Kereskai
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  7. D. Lőrinczy
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Correspondence to D. Lőrinczy.

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Wiegand, N., Vámhidy, L., Patczai, B. et al. Differential scanning calorimetric examination of transverse carpal ligament in carpal tunnel disease. J Therm Anal Calorim 95, 793–796 (2009). https://doi.org/10.1007/s10973-008-9417-0

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  • DOI: https://doi.org/10.1007/s10973-008-9417-0

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