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Thermal, spectral and antimicrobial study on some Cu(II) complexes with ligands bearing biguanide moieties

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Abstract

New complexes of type [Cu(HTBG)2]Cl2 (1), [Cu(TBG)2]·3H2O (2) and [CuL]·nH2O (3) L:L1, n = 2 and (4) L:L2, n = 1 (HTBG: 2-tolylbiguanide, L1 and L2: ligands resulted from 2-tolylbiguanide, ammonia/hydrazine and formaldehyde one pot condensation) were synthesised and characterised. The features of complexes have been assigned from microanalytical, IR and UV–Vis data. Redox behaviour was established by cyclic voltammetry. The in vitro qualitative and quantitative antimicrobial activity assays showed that the complexes exhibited variable antimicrobial activity against Gram-negative and Gram-positive strains isolated from the hospital environment. The thermal analyses have evidenced the thermal intervals of stability and also the thermodynamic effects that accompany them. After water elimination, complexes have a similar thermal behaviour. Processes as water elimination, melting, chloride anion removal as well as oxidative degradation of the organic ligands were observed. The final product of decomposition was copper (II) oxide.

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Authors and Affiliations

  1. Faculty of Chemistry, Department of Inorganic Chemistry, University of Bucharest, 90-92 Panduri Str. Sector 5, 050663, Bucharest, Romania

    Rodica Olar, Mihaela Badea, Dana Marinescu & Eliza Frunza

  2. Faculty of Chemistry, Department of Analytical Chemistry, University of Bucharest, 90-92 Panduri Str. Sector 5, 050663, Bucharest, Romania

    Emilia Elena Iorgulescu

  3. Faculty of Biology, Department of Microbiology, University of Bucharest, 1-3 Aleea Portocalilor St., Sector 6, 060101, Bucharest, Romania

    Veronica Lazar & Carmen Chifiriuc

Authors
  1. Rodica Olar
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  2. Mihaela Badea
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  3. Dana Marinescu
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  4. Emilia Elena Iorgulescu
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  5. Eliza Frunza
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  6. Veronica Lazar
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  7. Carmen Chifiriuc
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Correspondence to Rodica Olar.

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Olar, R., Badea, M., Marinescu, D. et al. Thermal, spectral and antimicrobial study on some Cu(II) complexes with ligands bearing biguanide moieties. J Therm Anal Calorim 99, 815–821 (2010). https://doi.org/10.1007/s10973-009-0414-8

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  • DOI: https://doi.org/10.1007/s10973-009-0414-8

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