Abstract
Osteoarthritis, although classically conceived of as a degenerative consequence of aging, is a disease with an increasingly well-characterized molecular pathophysiology. Pathologic changes in cartilage composition and molecular organization, as well as elevated water content, alter the exquisite balance of biomechanical properties. Much of what is known about changes in the extracellular matrix in osteoarthritis comes from animal models.
Previously, thermogravimetric methods have not been used for compositional thermoanalytical study of normal and degenerative human hyaline cartilage. For this reason the research group established a sufficient new thermogravimetric protocol, which proved water content elevation contributing to disease progression.
Similar content being viewed by others
References
M. Lethbridge-Çejku, J. S. Schiller and L. Bernadel, National Center for Health Statistics, 10 (2004) 222.
R. C. Lawrence et al., C. G. Helmick, Arthritis Rheum, 41 (1998) 778.
J. Hootman, J. Bolen, C. Helmick and G. Langmaid, Morbidity and Mortality Weekly Report, 55 (2006) 1089.
C. W. Wu and K. C. Kalunian, Clin. Geriatr. Med., 21 (2005) 589.
E. D. Harris et al., Kelley’s Textbook of Rheumatology 7th Ed., Elsevier Saunders, Philadelphia 2005, p. 1496.
P. Than and L. Kereskai, J. Therm. Anal. Cal., 82 (2005) 213.
M. A. Soltz and G. A. Ateshian, J. Biomechanics, 31 (1998) 927.
C. C.-B. Wang, J.-M. Deng, G. A. Ateshian and C. T. Hung, J. Biomechanical Eng., 124 (2002) 557.
H. J. Mankin and K. D. Brandt, Osteoarthritis: Diagnosis and Medical/Surgical Management, WB Saunders, Philadelphia 1992, p. 109.
D. Herbage, A. Huc and D. Chabrand, Biochim. Biophys. Acta, 271 (1972) 339
H. Muir, Ann. Rheum. Dis., 36 (1977) 199.
H. J. Mankin, V. C. Mow and J. A. Buckwalter, Orthopaedic Basic Science, AAOS, Chicago 1994, p. 1.
P. Than and D. Lőrinczy, Thermochim. Acta, 404 (2003) 149.
O. T. Sørensen, Thermochim. Acta, 50 (1981) 163.
F. Paulik and J. Paulik, Thermochim. Acta, 100 (1986) 23.
J. Rouquerol, Thermochim. Acta, 144 (1989) 209.
P. S. Gill, S. R. Sauerbrunn and B. S. Crowe, J. Thermal Anal., 38 (1992) 255.
M. Reading, Thermal Analysis — Techniques and Applications, The Royal Society of Chemistry, Cambridge 1992, p. 127.
R. Riesen, J. Thermal Anal., 53 (1998) 365.
M. Reading, Handbook of Thermal Analysis and Calorimetry, Elsevier Science B. V., Amsterdam 1998, p. 423.
P. Than, C. Vermes, B. Schäffer and D. Lőrinczy, Thermochim. Acta, 346 (2000) 147.
T. Sillinger, P. Than, B. Kocsis and D. Lőrinczy, J. Therm. Anal. Cal., 82 (2005) 221.
H. E. Kissinger, Anal. Chem., 29 (1957) 1702.
M. Arnold, P. Somogyvári, J. Paulik and F. Paulik, J. Thermal Anal., 32 (1987) 679.
D. Doyle, Nature, 207 (1965) 290.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Sohár, G., Pallagi, E., Szabó-Révész, P. et al. New thermogravimetric protocol for the investigation of normal and damaged human hyaline cartilage. J Therm Anal Calorim 89, 853–856 (2007). https://doi.org/10.1007/s10973-007-8256-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10973-007-8256-8