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Characterization of human cartilage in degenerated spine disease with differential scanning calorimetry

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Abstract

The purpose of this study was to further characterize the altered metabolism spondylolisthesis that promotes disease progression. Degenerative human cartilage (intervertebral disc, facet joint and vertebral end-plate) was obtained during 15 posterior lumbar spine interbody fusion procedures performed at the University of Szeged. The thermal properties of samples were determined by differential scanning calorimetry (Mettler-Toledo DSC 821e). Greatest change in the enthalpy was observed in the intervertebral disc samples: −1600.78 J g−1. Denaturation caused by heating in the normal human hyaline cartilage needed −1493.31 J g−1 energy. Characterization of the altered metabolism that promotes disease progression should lead to future treatment options.

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Authors and Affiliations

  1. Department of Orthopaedics, University of Szeged, Faculty of Medicine, Semmelweis u. 6, 6725, Szeged, Hungary

    L. Mécs, G. Sohár & K. Tóth

  2. Department of Pharmaceutical Technology, University of Szeged, Faculty of Pharmacy, Eötvös u. 6, 6720, Szeged, Hungary

    Z. Aigner & Piroska Szabó-Révész

Authors
  1. L. Mécs
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  2. Z. Aigner
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  3. G. Sohár
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  4. Piroska Szabó-Révész
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  5. K. Tóth
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Correspondence to K. Tóth.

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Mécs, L., Aigner, Z., Sohár, G. et al. Characterization of human cartilage in degenerated spine disease with differential scanning calorimetry. J Therm Anal Calorim 95, 809–811 (2009). https://doi.org/10.1007/s10973-008-9415-2

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  • DOI: https://doi.org/10.1007/s10973-008-9415-2

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