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Grinding of drugs with pharmaceutical excipients at cryogenic temperatures

Part I. Cryogenic grinding of piroxicam-polyvinylpyrrolidone mixtures

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Abstract

The effect of cryogenic grinding on the piroxicam and its mixtures with polyvinylpyrrolidone (PVP) was studied by powder X-ray diffraction and differential scanning calorimetry (DSC). The crystallization of the amorphous piroxicam obtained during cryogrinding showed two events in a DSC curve (noticeable for pure piroxicam, and much more pronounced for the PVP-piroxicam mixtures). For the same measurement conditions, the intensity ratio of the peaks corresponding to the two events differed for the PVP-piroxicam mixtures of different drug-excipient ratios. The temperatures, at which these events were observed, increased with the increase in the PVP-concentration in the mixture. For the mixtures with a high relative content of PVP (≥60%), crystallization was not observed at all. Only one glass transition was revealed for the mixture containing 80% PVP suggesting that a molecular alloy was formed.

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Authors and Affiliations

  1. Institute of Solid State Chemistry and Mechanochemistry SB RAS, 18 Kutateladze, Novosibirsk, 630128, Russia

    T. P. Shakhtshneider, S. A. Myz, E. V. Boldyreva & V. V. Boldyrev

  2. Research and Education Centre ‘Molecular Design and Ecologically Safe Technologies’ at Novosibirsk State University, 2 Pirogova, Novosibirsk, 630090, Russia

    T. P. Shakhtshneider, S. A. Myz, E. V. Boldyreva & V. V. Boldyrev

  3. Laboratoire de Dynamique et Structure des Matériaux Moléculaires, UMR CNRS 8024, ERT 1018, Université de Lille 1 Bât. P5, 59655, Villeneuve d’Ascq, France

    F. Danède, F. Capet, J. F. Willart & M. Descamps

Authors
  1. T. P. Shakhtshneider
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  2. F. Danède
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  3. F. Capet
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  4. J. F. Willart
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  5. M. Descamps
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  6. S. A. Myz
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  7. E. V. Boldyreva
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  8. V. V. Boldyrev
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Correspondence to T. P. Shakhtshneider.

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Shakhtshneider, T.P., Danède, F., Capet, F. et al. Grinding of drugs with pharmaceutical excipients at cryogenic temperatures. J Therm Anal Calorim 89, 699–707 (2007). https://doi.org/10.1007/s10973-006-7958-7

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