Skip to main content
SpringerLink
Log in

Performance validation of step-isothermal calorimeters

Application of a test and reference reaction

  • Published:
Journal of Thermal Analysis and Calorimetry Aims and scope Submit manuscript

Abstract

Isothermal calorimetry is becoming indispensable as a tool for the study of a wide variety of systems. As with all scientific instruments it is essential that robust calibration routines be developed in order to validate the data obtained. Chemical test reactions offer many advantages over (the traditionally used) joule effect heating methods, not least because they have the potential to validate instrument performance (i.e. they can be used to assess all aspects of calorimeter operation). In this work the results of a validation exercise, conducted by Thermal Hazard Technology as part of an installation routine, using the base catalysed hydrolysis of methyl paraben are discussed. In the case described, a systematic misreporting of the reported temperature of a calorimeter was identified, caused by an upgrade to the calorimeter's firmware, a discrepancy which may not have been noted using traditional electrical calibration methods and one which highlights the importance of both manufacturers and end-users adopting chemical test reactions into their test and validation routines.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. SE Harding BZ Chowdhry (2001) Protein-ligand Interactions: Hydrodynamics and Calorimetry, A Practical Approach. Oxford University Press Oxford

    Google Scholar 

  2. WH Ward GA Holdgate (2001) Progr. Med. Chem. 38 309 Occurrence Handle1:CAS:528:DC%2BD3MXivVGntbY%3D

    CAS  Google Scholar 

  3. G Buckton (2001) Pharm. Tech. Eur. November 44

    Google Scholar 

  4. MA Phipps LA Mackin (2000) Pharm. Sci. Tech. Today 3 9 Occurrence Handle1:CAS:528:DC%2BD3cXosFWnuw%3D%3D

    CAS  Google Scholar 

  5. K Thompson (2000) Thermochim. Acta, 355 83 Occurrence Handle10.1016/S0040-6031(00)00461-5 Occurrence Handle1:CAS:528:DC%2BD3cXjvF2qu7Y%3D

    Article  CAS  Google Scholar 

  6. S Gaisford G Buckton (2001) Thermochim. Acta 380 185 Occurrence Handle10.1016/S0040-6031(01)00669-4 Occurrence Handle1:CAS:528:DC%2BD3MXos1ChsLk%3D

    Article  CAS  Google Scholar 

  7. AE Beezer S Gaisford AK Hills RJ Willson JC Mitchell (1999) Int. J. Pharm. 179 159 Occurrence Handle10.1016/S0378-5173(98)00336-6 Occurrence Handle1:CAS:528:DyaK1MXhsVensb8%3D

    Article  CAS  Google Scholar 

  8. D Giron (1995) Thermochim. Acta 248 1 Occurrence Handle10.1016/0040-6031(94)01953-E Occurrence Handle1:CAS:528:DyaK2MXivVOrtr8%3D

    Article  CAS  Google Scholar 

  9. C. V. Skaria, S. Gaisford, M. A. A. O'Neill, G. Buckton and A. E. Beezer, Int. J. Pharm., In press, (2005).

  10. I Wadso R Goldberg (2001) Pure Appl. Chem. 73 1625 Occurrence Handle1:CAS:528:DC%2BD38XjslWrug%3D%3D

    CAS  Google Scholar 

  11. AK Hills AE Beezer JC Mitchell JA Connor (2001) Thermochim. Acta 380 19 Occurrence Handle10.1016/S0040-6031(01)00630-X Occurrence Handle1:CAS:528:DC%2BD3MXotlWms7g%3D

    Article  CAS  Google Scholar 

  12. AE Beezer AK HillS MAA O'Neill AC Morris KTE Kierstan RM Deal LJ Waters J Hadgraft JC Mitchell JA Connor JE Orchard RJ Willson TC Hofelich J Beaudin G Wolf F Baitalow S Gaisford RA Lane G Buckton MA Phipps RA Winneke EA Schmitt LD Hansen D O'Sullivan MK Parmar (2001) Thermochim. Acta 380 13 Occurrence Handle1:CAS:528:DC%2BD3MXotlWms7s%3D

    CAS  Google Scholar 

  13. MAA O'Neill AE Beezer C Labetoulle L Nicolaides JC Mitchell JA Orchard JA Connor RB Kemp D Olomolaiye (2003) Thermochim. Acta 399 63 Occurrence Handle10.1016/S0040-6031(02)00401-X

    Article  Google Scholar 

  14. A Bakri LHM Janssen J Wilting (1988) J. Thermal Anal. 33 185

    Google Scholar 

  15. RJ Willson AE Beezer JC Mitchell W Loh (1995) J. Phys. Chem. 99 7108 Occurrence Handle10.1021/j100018a051 Occurrence Handle1:CAS:528:DyaK2MXlt1Srsrs%3D

    Article  CAS  Google Scholar 

  16. AE Beezer AC Morris MAA O'Neill RJ Willson AK Hills JC Mitchell JA Connor (2001) J. Phys. Chem. B 105 1212 Occurrence Handle10.1021/jp003539s Occurrence Handle1:CAS:528:DC%2BD3MXksVyktw%3D%3D

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Victorian College of Pharmacy, Monash University, Parkville, Victoria , Australia, 3052, 381 Royal Parade

    Finnin B A & O'Neill M A A

  2. University of London, School of Pharmacy, London , UK, WC1N 1AX, 29-39 Brunswick Square

    Gaisford S , Beezer A E & Hadgraft J

  3. Thermal Hazard Technology, 1 North House, Bletchley, Buckinghamshire , UK, MK1 1SW, Bond Avenue

    Sears P

Authors
  1. Finnin B A
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. O'Neill M A A
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Gaisford S
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Beezer A E
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hadgraft J
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Sears P
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to O'Neill M A A.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Finnin, B.A., O'Neill, M.A.A., Gaisford, S. et al. Performance validation of step-isothermal calorimeters . J Therm Anal Calorim 83, 331–334 (2006). https://doi.org/10.1007/s10973-005-7223-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10973-005-7223-5

Keywords

Search

Navigation