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Combining mesoporous silica–magnetite and thermally-sensitive polymers for applications in hyperthermia

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Abstract

In this work, the synthesis strategy of a multifunctional system of [SBA-16/P(N-iPAAm)/Fe3O4] hybrids of interest for magneto-hyperthermia was explored. Magnetite nanoparticles coated by mesoporous silica were prepared by an alternative chemical route using neutral surfactant and without the application of any functionalization method. Monomer adsorption followed by in situ polymerization initiated by a radical was used to incorporate the hydrogel into the pore channels of the silica nanocomposite. Structural and magnetic characterization of the obtained materials was carried out by using thermal analysis, X-ray diffraction, N2 adsorption desorption isotherms, 57Fe Mössbauer spectroscopy, vibrating sample magnetometry and transmission electron microscopy. Measurements of alternating current magnetic-field-induced heating behaviour under different applied magnetic fields showed that the [SBA-16/P(N-iPAAm)/Fe3O4] hybrid here synthesized is suitable as a hyperthermia agent for biological applications.

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Acknowledgments

The authors are grateful to CNPq—Conselho Nacional de Desenvolvimento Científico e Tecnológico, FAPEMIG—Fundação de Amparo à Pesquisa do Estado de Minas Gerais, and CAPES—Coordenação de Aperfeiçoamento de pessoal de Nível Superior, for the financial support.

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Authors and Affiliations

  1. Serviço de Nanotecnologia, Centro de Desenvolvimento da Tecnologia Nuclear, Belo Horizonte, MG, Brazil

    R. C. S. Azevedo, W. A. A. Macedo & E. M. B. Sousa

  2. Laboratório de Ciência e Tecnologia de Polímeros, Departamento de Engenharia Química, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil

    R. G. Sousa

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  1. R. C. S. Azevedo
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  2. R. G. Sousa
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  3. W. A. A. Macedo
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  4. E. M. B. Sousa
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Correspondence to E. M. B. Sousa.

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Azevedo, R.C.S., Sousa, R.G., Macedo, W.A.A. et al. Combining mesoporous silica–magnetite and thermally-sensitive polymers for applications in hyperthermia. J Sol-Gel Sci Technol 72, 208–218 (2014). https://doi.org/10.1007/s10971-014-3307-7

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  • DOI: https://doi.org/10.1007/s10971-014-3307-7

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