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Standardisation of a 68(Ge+Ga) solution within the CCRI(II)-K2.Ge-68 key comparison

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Abstract

This paper presents the work performed in IFIN-HH, Radionuclide Metrology Laboratory, for the standardization of a 68(Ge+Ga) solution, within our participation in the key-comparison codified as CCRI(II)-K2.Ge-68, organised by the CIPM-CCRI(II). Four methods were used: (i) the 4πβ(PC)-γ coincidence method, efficiency extrapolation variant, (ii) the liquid scintillation counting in the variant of triple to double coincidence ratio, (iii) the gamma-ray spectrometry and (iv) the well-type ionisation chamber measurement. The final result was calculated as “power moderate weighted mean” of all results. The results obtained in all methods are presented as relative figures.

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References

  1. Be M-M, Chiste V, Dulieu C, Mugeot X, Chechev V, Kondev F, Nicols AL, Huang X, Wang B (2013) Monographie BIPM-5. Table of radionuclides. Vol 7–A 14–245. Bureau International des Poids et Mesures

  2. Luca A, Sahagia M, Antohe A (2012) Measurementsof 64Cu and 68Ga half-lives and γ- ray emission intensities. Appl Radiat Isot 70:1876–1880

    Article  CAS  Google Scholar 

  3. Zimmerman BE (2013) Current status and future needs for standards of radionuclides used in positron emission tomography. Appl Radiat Isot 76:31–37

    Article  CAS  Google Scholar 

  4. CCRI(II)-13-37.(2013) CCRI(II) decision on the evaluation of the key comparison reference value in key and supplementary comparisons. http://www.bipm.org

  5. Zimmerman BE, Bergeron DE, Fitzgerald R, Cessna JT (2016) Long-term stability of carrier added Ge-68 standardized solutions. Appl Radiat Isot 109:214–216. doi:10.1016/j.apradiso.2015.11.078

    Article  CAS  Google Scholar 

  6. Grigorescu LE, Neguţ CD, Luca A, Răzdolescu AC, Tănase M (2004) Standardization of 68(Ge+Ga). Appl Radiat Isot 60:429–431

    Article  CAS  Google Scholar 

  7. Eberhan, T., Szucs, Z., Cîmpeanu, C., Dudu, D., Crăciun, L., Luca, A., Sahagia, M., Zeevaart, J.R. (2011) Production of 68Ge from natural Zink by cyclotron. 1st world congress on gallium-68 and peptide receptor radionuclide therapy (PRRNT) THERANOSTICS—on the way to personalized medicine. Zentralklinik Bad Berka, Germany June 23–26

  8. Yamada T, Ishizu H, Kawada Y, Yunoki A, Yano S (2016) Activity measurement of 68Ge–68Ga by use of 4π(β++γ) integral counting method. Appl Radiat Isot 109:325–329. doi:10.1016/j.apradiso.2015.12.006

    Article  CAS  Google Scholar 

  9. Schönfeld E, Schötzig U, Günter E (1994) Standardization and decay data of 68Ge/68Ga. Appl Radiat Isot 45:955–961

    Article  Google Scholar 

  10. Sahagia M, Luca A, Antohe A, Ivan C (2012) Standardization of 64Cu and 68Ga by the 4π(PC)β –γ coincidence method and calibration of the ionization chamber. Appl Radiat Isot 70(9):2025–2030

    Article  CAS  Google Scholar 

  11. Sahagia M, Ioan R, Luca A, Antohe A, Ivan C, Neacsu B, Ghioca C (2014) Standardisation of 18F and its use for the Romanian PET traceability chain assurance. Appl Radiat Isot 87:14–18

    Article  CAS  Google Scholar 

  12. Sahagia M, Ioan M-R, Antohe A, Luca A, Ivan C (2016) Measurement of 124I. Appl Radiat Isot 109:349–353. doi:10.1016/j.apradiso.2015.12.002

    Article  CAS  Google Scholar 

  13. Zimmerman BE, Cessna JT, Fitzgerald R (2008) Standardization of 68Ge/68Ga using three liquid scintillation counting based methods. J Res Natl Inst Stand Technol 113:265–280

    Article  CAS  Google Scholar 

  14. Ivan C, Wätjen AC, Cassette P, Sahagia M, Antohe A, Grigorescu EL (2010) Participation in the CCRI(II)-K2.H-3 comparison and study of the new TDCR-LS counter with 6 CPMs. Appl Radiat Isot 68:1543–1545

    Article  CAS  Google Scholar 

  15. Sahagia M, Antohe A, Ioan M-R, Luca A, Ivan C (2014) Standardization of Tc-99 by two methods and participation at the CCRI(II)-K2.Tc-99 comparison. Appl Radiat Isot 87:410–413

    Article  CAS  Google Scholar 

  16. Cassette P. (2015) GeGa68 software. Private communication

  17. Broda R, Cassette P, Kossert K (2007) Radionuclide metrology using liquid scintillation counting. Metrologia 44:S36–S52

    Article  CAS  Google Scholar 

  18. Sahagia M, Wätjen AC, Luca A, Ivan C (2010) IFIN-HH ionization chamber calibration and its validation; electrometric system improvement. Appl Radiat Isot 68:1266–1269

    Article  CAS  Google Scholar 

  19. Joint Committee for Guides in Metrology (2010) GUM: evaluation of measurement data—guide to the expression of uncertainty in measurement, JCGM. 100:2008

  20. CCRI(II)/13-18. (2012) EUR 25355 of the JCR-IRMM. S. Pommé. Determination of a reference value, associated standard uncertainty and degrees of equivalence for CCRI(II) key comparison data. EC. JRC scientific and policy reports.JRC 71285. ISBN 978-92-79-25104-7. ISSN 1831-9424

  21. Pommé S (2015) Determination of a reference value and its uncertainty through a power-moderated mean. Metrologia 52:S200–S212

    Article  Google Scholar 

  22. Sahagia M, Luca A, Margineanu RM, Navarro Ortega N, Peyres V, Perez Lopez B, Garcia Torano E, Suarez-Navarro JA (2013) Determination of the content of natural radionuclides in furnace slag used for the preparation of standard sources. J Radioanal Nucl Chem 298:2037–2044

    Article  CAS  Google Scholar 

  23. Sahagia M, Luca A, Antohe A, Ioan M-R, Garcia Toraño E (2016) Application of the power-moderate weighted mean (PMM) concept in the calculation of reference values of interlaboratory comparisons. Rom J Phys 61(3–4):697–706

    Google Scholar 

  24. Paule RC, Mandel J (1982) Consensus values and weighting factors. J Res Nat Bur Std 87:377–385

    Article  Google Scholar 

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Acknowledgments

This work was supported by a grant of the Romanian National Authority for Scientific Research and Innovation (ANCSI): Program Nucleu, Project PN-IFIN-HH, code 16 42 02 04.

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Authors and Affiliations

  1. Horia Hulubei National Institute of Physics and Nuclear Engineering, IFIN-HH, 30 Reactorului Street, 077125, Măgurele, Ilfov County, Romania

    Maria Sahagia, Aurelian Luca, Andrei Antohe, Mihail-Răzvan Ioan, Cătălina Cîmpeanu, Cătălina Barna & Constantin Ivan

Authors
  1. Maria Sahagia
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  2. Aurelian Luca
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  3. Andrei Antohe
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  4. Mihail-Răzvan Ioan
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  5. Cătălina Cîmpeanu
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  6. Cătălina Barna
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  7. Constantin Ivan
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Correspondence to Maria Sahagia.

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Sahagia, M., Luca, A., Antohe, A. et al. Standardisation of a 68(Ge+Ga) solution within the CCRI(II)-K2.Ge-68 key comparison. J Radioanal Nucl Chem 311, 983–990 (2017). https://doi.org/10.1007/s10967-016-4981-4

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  • DOI: https://doi.org/10.1007/s10967-016-4981-4

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