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Radiocomplexation and biological evaluation of nemonoxacin in mice infected with multiresistant Staphylococcus aureus and penicillin-resistant Streptococci

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Abstract

In the current investigation nemonoxacin (NMX) was radiolabeled with 99mTc in the presence of stannous chloride dihydrate as reducing agent. Factors affecting the percent labeling yield of 99mTc-Nemonoxacin (99mTc-NMX) complex were studied in details. The labeled compound was radiochemically characterized and was stable for a time up to 4 h. The complex showed in vitro saturated binding with living multiresistant Staphylococcus aureus (MRSA) and penicillin-resistant Streptococci (PRSC). Biodistribution and imaging studies were performed. All results showed that 99mTc-NMX complex is a promising agent for MRSA and PRSC infection imaging and can differentiate between infected and sterile inflammations.

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Authors and Affiliations

  1. Labelled Compounds Department, Atomic Energy Authority, Cairo, 13759, Egypt

    O. A. El-Kawy & K. Farah

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  1. O. A. El-Kawy
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  2. K. Farah
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Correspondence to O. A. El-Kawy.

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El-Kawy, O.A., Farah, K. Radiocomplexation and biological evaluation of nemonoxacin in mice infected with multiresistant Staphylococcus aureus and penicillin-resistant Streptococci . J Radioanal Nucl Chem 306, 123–130 (2015). https://doi.org/10.1007/s10967-015-4069-6

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  • DOI: https://doi.org/10.1007/s10967-015-4069-6

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