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Validation of an extraction paper chromatography (EPC) technique for estimation of trace levels of 90Sr in 90Y solutions obtained from 90Sr/90Y generator systems

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Abstract

While the extraction paper chromatography (EPC) technique constitutes a novel paradigm for the determination of few Becquerels of 90Sr in MBq quantities of 90Y obtained from 90Sr/90Y generator, validation of the technique is essential to ensure its usefulness as a real time analytical tool. With a view to explore the relevance and applicability of EPC technique as a real time quality control (QC) technique for the routine estimation of 90Sr content in generator produced 90Y, a systematic validation study was carried out diligently not only to establish its worthiness but also to broaden its horizon. The ability of the EPC technique to separate trace amounts of Sr2+ in the presence of large amounts of Y3+ was verified. The specificity of the technique for Y3+ was demonstrated with 90Y obtained by neutron irradiation. The method was validated under real experimental conditions and compared with a QC method described in US Pharmacopeia for detection of 90Sr levels in 90Y radiopharmaceuticals.

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Acknowledgments

The authors would like to thank Dr. Rubel Chakravarty of our division for providing 90Y from the electrochemical 90Sr/90Y generator. Research at the Bhabha Atomic Research Centre is part of the ongoing activities of the Department of Atomic Energy, India and fully supported by government funding.

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Authors and Affiliations

  1. Isotope Applications & Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400 085, India

    Usha Pandey, Yogendra Kumar & Ashutosh Dash

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  1. Usha Pandey
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  2. Yogendra Kumar
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  3. Ashutosh Dash
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Correspondence to Ashutosh Dash.

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Pandey, U., Kumar, Y. & Dash, A. Validation of an extraction paper chromatography (EPC) technique for estimation of trace levels of 90Sr in 90Y solutions obtained from 90Sr/90Y generator systems. J Radioanal Nucl Chem 300, 355–360 (2014). https://doi.org/10.1007/s10967-014-2981-9

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  • DOI: https://doi.org/10.1007/s10967-014-2981-9

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