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18FDG conjugated magnetic nanoparticle probes: synthesis and in vitro investigations on MCF-7 breast cancer cells

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Abstract

18FDG conjugated magnetic iron oxide nanoparticles (MNPs) were synthesized as PET-MR hybrid imaging agent. Synthesized and characterized NPs were then applied to MCF-7 human breast cancer cells. 18FDG conjugated MNPs exhibited the cell incorporation ratio up to 30 %. As well as the characterization studies, apoptotic effects were observed depending on the cellular incorporations by the time. In conclusion, synthesized structures could have a potential as hybrid imaging agent in PET-MR imaging systems besides apoptotic effect on cancer cells.

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Acknowledgments

The authors thank to Ege University Scientific Research Fund for the financial support with the Project Numbers 2008 NBE 08 and 2009 FEN 007. Authors also thank to Adnan Menderes University Science Technology Research and Application Center for cell culture experiments.

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Authors and Affiliations

  1. Institute of Nuclear Sciences, Ege University, 35100, Bornova, Izmir, Turkey

    Feriha Ozkaya, Perihan Unak & E. Ilker Medine

  2. Science and Technology Research and Application Center (ADU-BILTEM), Adnan Menderes University, 09100, Aydın, Turkey

    Serhan Sakarya

  3. Department of Infectious Diseases and Clinical Microbiology, Adnan Menderes University School of Medicine, 09100, Aydin, Turkey

    Serhan Sakarya

  4. Biochemistry Department, Faculty of Science, Ege University, 35100, Bornova, Izmir, Turkey

    Gülcan Unak & Suna Timur

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  1. Feriha Ozkaya
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  2. Perihan Unak
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  3. E. Ilker Medine
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  5. Gülcan Unak
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Correspondence to Perihan Unak.

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Ozkaya, F., Unak, P., Medine, E.I. et al. 18FDG conjugated magnetic nanoparticle probes: synthesis and in vitro investigations on MCF-7 breast cancer cells. J Radioanal Nucl Chem 295, 1789–1796 (2013). https://doi.org/10.1007/s10967-012-2248-2

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  • DOI: https://doi.org/10.1007/s10967-012-2248-2

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