Skip to main content
SpringerLink
Log in

The effects of gamma rays upon monohydrated and anhydrous asparagine: a DSC study in sealed pans

  • Published:
Journal of Radioanalytical and Nuclear Chemistry Aims and scope Submit manuscript

Abstract

Non-irradiated and gamma irradiated monohydrated (l Asn·H2O) and anhydrous (l Asn) asparagines, in solid state, were studied by means of DSC. The samples were irradiated at room temperature with gamma radiations using a 137Cs source. The exposure doses ranged between 1 and 10 kGy. All samples were scanned in sealed pans, from room temperature to a temperature beyond the melting point. The DSC scans of l Asn·H2O samples in sealed crucibles revealed the presence of two dehydration processes and one of decomposition and only decomposition in the case of l Asn. The influence of gamma irradiation consisted in decreasing the enthalpy of dehydration and of decomposition. A decomposition mechanism is proposed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Contineanu M, Contineanu I, Neacsu A, St Perisanu (2010) The effect of γ rays upon monohydrated asparagine. A DSC study. Rad Phys Chem 79:1047–1051

    Article  CAS  Google Scholar 

  2. Verbist JJ, Lehmann MS, Koetzle TF, Hamilton WC (1972) Precision neutron diffraction structure determination of protein and nucleic acid components. VI. The crystal and molecular structure of the aminoacid l-asparagine monohydrate. Acta Crystallogr B 28:3006–3013

    Article  CAS  Google Scholar 

  3. Whitson KB, Lukan AM, Marlowe RL, Lee SA, Anthony L, Rupprecht A (1998) Binding of the water of primary hydration to the sodium and cesium salts of deoxyribonucleic acid and potassium hyalouronate. Phys Rev E58:2370–2377

    Google Scholar 

  4. Ramanadham M, Sikka SK, Chidambaram R (1972) Structure of l-asparagine monohydrate by neutron diffraction. Acta Crystallogr B 28:3000–3005

    Article  CAS  Google Scholar 

  5. Yamada K, Hashime D, Shimizu T, Yokoyama S (2007) l-asparagine. Acta Crystallogr E63:3802–3803

    Google Scholar 

  6. Zubavichus Y, Fuchs O, Weinhardt L, Heske C, Umbach E, Denlinger JD, Grunze M (2004) Soft X-ray-induced decomposition of amino acids: an XPS, mass spectrometry, and NEXAFS study. Radiat Res 161:346–358

    Article  CAS  Google Scholar 

  7. Cherezov V, Riedl KM, Caffrey M (2002) Too hot to handle? Synchrotron X-ray damage of lipid membranes and mesophases. J Synchrotron Radiat 9:333–341

    Article  CAS  Google Scholar 

  8. Elpeth F, Garman A, Schneider TR (1997) Macromolecular cryocrystallography. J Appl Cryst 30:211–237

    Article  Google Scholar 

  9. Wade RH (1984) The temperature dependence of radiation damage in organic and biological materials. Ultramicroscopy 14:265–270

    Article  CAS  Google Scholar 

  10. Adams SM, Budzinski EE, Box HC (1976) Primary oxidation and reduction products in X-irradiated aspartic acid. J Chem Phys 65:998–1001

    Article  CAS  Google Scholar 

  11. Box HC, Freund HG, Lilga KT, Budzinski EE (1970) Magnetic resonance studies of the oxidation and reduction of organic molecules by ionizing radiations. J Phys Chem 74:40–52

    Article  CAS  Google Scholar 

  12. Lee JY, Box HC (1973) ESR and ENDOR studies of dl-serine irradiated at 428 K. J Chem Phys 59:2509–2512

    Article  CAS  Google Scholar 

  13. Li J, Wang Z, Yang X, Hu L, Liu Y, Wang C (2006) Decomposition or subliming? An investigation of thermal behavior of l-leucine. Thermochim Acta 447:147–153

    Article  CAS  Google Scholar 

  14. Menezes AS, Ardito FM, Dos Santos AO, Moreno AJD, Lima RJC, Hayashi MA, Cardoso LP (2011) Characterization of the time-dependent l-asparagine monohydrate crystal phase transition. J Appl Cryst 44:954–957

    Article  Google Scholar 

  15. Deepti J, Bharadwaj S, Ganesan V, Awasthi AM, Nath R (2011) Thermally stimulated dehydration studies in l-asparagine monohydrate. AIP Conf Proc 1349:159–160

    Google Scholar 

  16. Dong Z, Salsbury JS, Zhou D, Munson EJ, Schroeder SA, Prakash I, Viazovkin S, Wight CA, Grant DWJ (2002) Dehydration kinetics of neotame monohydrate. J Pharm Sci 91(6):1423–1430

    Article  CAS  Google Scholar 

  17. Guarini GGT, Dei L (1998) Kinetics and mechanism of the thermal dehydration of l. asparagine monohydrate microcrystals and single crystals: role of ageing. Thermochim Acta 311:129–140

    Article  CAS  Google Scholar 

  18. Moreno AJD, Freire PTC, Guedes I, Melo J, Mendes-Filho FEA, Sanjurjo JA (1999) Raman scattering studies of monohydrated l-asparagine. Braz J Phys 29(2):380–387

    Article  CAS  Google Scholar 

  19. Marciniec B, Kozak M, Wachowski L, Ogrodowcyk M (2003) Evaluation of radiostability of some steroid derivatives. J Therm Anal Cal 73:473–478

    Article  CAS  Google Scholar 

  20. Marciniec B, Kozak M, Ogrodowcyk M (2004) DSC study of radiostability of 1,4-dihydropyridine derivates. J Therm Anal Cal 77:581–596

    Article  CAS  Google Scholar 

  21. Neacsu A (2009) Doctoral Thesis. Department of Chemistry, University of Bucharest, Romania

  22. Wesolowski M, Erecinska J (2005) Relation between chemical structure of amino acids and their thermal decomposition. J Therm Anal Cal 82:307–313

    Article  CAS  Google Scholar 

  23. Sharma RK, Chan WG, Seeman JI, Hajaligol MR (2003) Formation of low molecular weight heterocycles and polycyclic aromatic compounds (PACs) in the pyrolysis of α-amino acids. J Anal Appl Pyrolysis 66:97–121

    Article  CAS  Google Scholar 

Download references

Acknowledgments

Support of the EU (ERDF) and Romanian Government, that allowed for acquisition of the research infrastructure under POS-CCE O 2.2.1 project INFRANANOCHEM-No. 19/01.03.2009, is gratefully acknowledged.

Author information

Authors and Affiliations

  1. Faculty of Chemistry, University of Bucharest, 4-12 Regina Elisabeta Blvd, 030018, Bucharest, Romania

    M. Contineanu

  2. Institute of Physical Chemistry, “I. Murgulescu”, 202 Spl. Independentei, 060021, Bucharest, Romania

    Ana Neacsu & Iulia Contineanu

  3. Faculty of Applied Chemistry and Material Science, University Politehnica Bucharest, 1 Polizu Str, 011061, Bucharest, Romania

    Stefan Perisanu

Authors
  1. M. Contineanu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ana Neacsu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Iulia Contineanu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Stefan Perisanu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ana Neacsu.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Contineanu, M., Neacsu, A., Contineanu, I. et al. The effects of gamma rays upon monohydrated and anhydrous asparagine: a DSC study in sealed pans. J Radioanal Nucl Chem 295, 379–384 (2013). https://doi.org/10.1007/s10967-012-2157-4

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10967-012-2157-4

Keywords

Search

Navigation