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Evaluation of the synergetic radio-chemotherapy effects of the radio labelled cisplatin for the treatment of glioma

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Abstract

The proposal of this work was to investigate the effect of the radioactive (NH3)2PtCl2, cis-diamminedichloroplatinum (II) or CDDP* on malignant glioma cells and verify if the low-dose continuous internal radio-chemotherapy would be able to produce additive effects. The antitumoral activity of CDDP* and the non labeled cisplatin, CDDP, were evaluated in glioblastoma. Cisplatin was cytotoxic for glioblastoma cells in a dose dependent manner. Treatment with CDDP*, (IC50 = 1.75 ± 0.07 μM), proved to be more potent than using just CDDP, (IC50 = 4.96 ± 0.40 μM). These results suggest that cisplatin is a very potent radiosensitizer evoking a supra additive effect. Internal radio-chemotherapy treatment based on CDDP* may be useful alternative to reduce the drug concentration required for effective inhibition of glioblastoma growth.

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Acknowledgment

The authors thank the CNPq and FAPEMIG for their financial support.

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Authors and Affiliations

  1. Centro de Desenvolvimento da Tecnologia Nuclear (CDTN)/Comissão Nacional de Energia Nuclear (CNEN), Av. Antônio Carlos 6627, Pampulha, Belo Horizonte, MG, 31270-901, Brazil

    Marcela Araugio Soares, Juliana Lage Mattos, Priscila Brunelli Pujatti, Alexandre Soares Leal & Raquel Gouvêa dos Santos

  2. Departamento de Biomedicina, Universidade Federal de Goiás, CAJ—Centro de Ciências Agrárias e Biológicas, BR 364, N. 3800—Setor Industrial, Jatai, GO, 75801-615, Brazil

    Wagner Gouvêa dos Santos

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  1. Marcela Araugio Soares
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  2. Juliana Lage Mattos
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  3. Priscila Brunelli Pujatti
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  4. Alexandre Soares Leal
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  5. Wagner Gouvêa dos Santos
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  6. Raquel Gouvêa dos Santos
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Correspondence to Alexandre Soares Leal.

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Soares, M.A., Mattos, J.L., Pujatti, P.B. et al. Evaluation of the synergetic radio-chemotherapy effects of the radio labelled cisplatin for the treatment of glioma. J Radioanal Nucl Chem 292, 61–65 (2012). https://doi.org/10.1007/s10967-011-1414-2

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  • DOI: https://doi.org/10.1007/s10967-011-1414-2

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