Skip to main content
SpringerLink
Log in

Investigation of the potential antitumor radioactive complex of platinum(II) with tetracycline

  • Published:
Journal of Radioanalytical and Nuclear Chemistry Aims and scope Submit manuscript

Abstract

The proposal of this work was to investigate the effect of the radioactive complex of platinum(II) with tetracycline, [PtCl2(C22H24N2O8)]*, or [Tc–Pt(II)]*, on K562 cells—blood human cells of leukemia—and verify if the internal radio-chemotherapy would be able to produce additional effects compared with the non-labelled complex, [PtCl2(C22H24N2O8)], or [Tc–Pt(II)]. The concentration required to inhibit 50 % of cellular growth, (IC50), was 2.5 ± 0.2 µM for [Tc–Pt(II)]* and 14.5 ± 0.9 µM for the non-labelled molecule [Tc–Pt(II)]. This result suggest that the [Tc–Pt(II)]* could be a potent radiosensitizer evoking a supra additive effect. Treatment using the internal radio-chemotherapy may be a useful alternative to reduce the drug concentration required for effective inhibition of the tumor growth.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Rosenberg B, Van Camp L, Trosco JE, Mansour VH (1969) Platinum compounds: a new class of potent antitumour agents. Nature 222:385–386

    Article  CAS  Google Scholar 

  2. Matthey J (1990) Drugs of the future. Bristol-Myers Squibb, New York

    Google Scholar 

  3. Pisters KM, Le Chevalier TJ (2005) Adjuvant chemotherapy in completely resected non-small-cell lung cancer. J Clin Oncol 23:3270–3278

    Article  CAS  Google Scholar 

  4. Jamieson ER, Lippard SJ (1999) Structure, recognition, and processing of cisplatin-DNA adducts. Chem Rev 99:2467–2498

    Article  CAS  Google Scholar 

  5. Silva H, Almeida M, César ET, Silveira JN, Garnier-Suillerot A, Paula FCS, Pereira-Maia EC, Fontes APJ (2008) Impact of the carbon chain length of novel platinum complexes. J Inorg Biochem Inorg Biochem 102:767–772

    Article  CAS  Google Scholar 

  6. Sykes AG (1988) Reactions of complexes of platinum metals with bio-molecules. Platin Met Rev 32:170–178

    CAS  Google Scholar 

  7. Pasini A, Zunino F (1987) New cisplatin analogues—on the way to better antitumor agents. Angew Chem Int Ed Engl 26:615–624

    Article  Google Scholar 

  8. Farrell N, Qu Y, Hacker MP (1990) Cytotoxicity and antitumor activity of bis(platinum)complexes. A novel class of platinum complexes active in cell lines resistant to both cisplatin and 1,2-diaminocyclohexane complexes. J Med Chem 33:2179–2184

    Article  CAS  Google Scholar 

  9. Junior ADC, Abrantes FM, Menezes MA, Leal AS, Oliveira MC (2005) Braz Arch Biol Technol 48:85–88

  10. Wolinskya JB, Colsonb YL, Grinstaff MW (2012) Local drug delivery strategies for cancer treatment: gels, nanoparticles, polymeric films, rods, and wafers. J Control Release 159:14–26

    Article  Google Scholar 

  11. Duan X, He C, Kron SJ, Lin W (2016) WIRES nanomed nanobiotechnol. doi:10.1002/wnan.1390

  12. Soares MA, Mattos JL, Pujatti PB, Leal AS, Santos WG, Santos RG (2011) Evaluation of the synergetic radio-chemotherapy effects of the radio labelled cisplatin for the treatment of glioma. J Radioanal Nucl Chem. doi:10.1007/s10967-011-1414-2

    Google Scholar 

  13. Júnior AD, Mota LG, Nunan EA, Wainstein AJ, Wainstein APD, Leal AS, Cardoso VN, De Oliveira MC (2007) Tissue distribution evaluation of stealth pH-sensitive liposomal cisplatin versus free cisplatin in Ehrlich tumor-bearing mice. Life Sci 80:659–664

    Article  Google Scholar 

  14. Bodnar NE, Dikiy MP, Medvedeva EP (2014) Photonuclear production and antitumor effect of radioactive cisplatin (195mPt). J Radioanal Nucl Chem 305:133–138

    Article  Google Scholar 

  15. Rozy K, Piyali C, Chadha VD (2014) Radiolabeling of cisplatin and its biodistribution in an experimental model of lung carcinogenesis. J Environ Pathol Toxicol Oncol 33:11–17

    Article  CAS  Google Scholar 

  16. Wheller RH, Spencer S (1995) Cisplatin plus radiation therapy. J Infus Chemother 5:61–66

    Google Scholar 

  17. Chatal JF, Hoefnagel CA (1999) Radionuclide therapy. Lancet 354:931–935

    Article  CAS  Google Scholar 

  18. Soares DCF, Menezes MABC, Santos RG, Ramaldes GA (2010) 159Gd: preparation and preliminary evaluation as a potential antitumoral radionuclide. J Radioanal Nucl Chem 284:315–320

    Article  CAS  Google Scholar 

  19. Soares DCF, Oliveira MC, Santos RG, Andrade MS, Vilela JMC, Cardoso VM, Ramaldes GA (2011) Liposomes radiolabeled with 159Gd-DTPA-BMA: preparation, physicochemical characterization, release profile and in vitro cytotoxic evaluation. Eur J Pharm Sci 42:462–469

    Article  CAS  Google Scholar 

  20. Chartone-Souza E, Loyola TL, Bucciarelli-Rodriguez M, Menezes MABC, Nicolas AR, Pereira-Maia EC (2005) Synthesis and characterization of a tetracycline–platinum(II) complex active against resistant bacteria. J Inorg Biochem 99:1001–1008

    Article  CAS  Google Scholar 

  21. Silva PP, de Paula FCS, Guerra W, Silveira JN, Botelho FV, Vieira Leda Q, Bortolotto T, Fischer FL, Bussi G, Terenzi H, Pereira-Maia EC (2010) Platinum(II) compounds of tetracyclines as potential anticancer agents: cytotoxicity, uptake and interactions with DNA. J Braz Chem Soc 7:1237–1246

    Article  Google Scholar 

  22. Pereira-Maia EC, Silva PP, Almeida WB, Santos HF, Marcial BL, Ruggiero R, Guerra W (2010) Tetraciclinas e glicilciclinas: uma visão geral. Quim Nova 33:700–706

    Article  CAS  Google Scholar 

  23. Leal AS, Júnior ADC, Abrantes FM, Menezes MABC, Ferraz V, Cruz TS, Cardoso VN, Oliveira MC (2006) Production of the radioactive antitumoral cisplatin. Appl Rad Isot 64:178–181

    Article  CAS  Google Scholar 

  24. Leal AS, Sepe FP, Gomes TCB (2014) J Radional Nucl Chem 300:645–651

    Article  CAS  Google Scholar 

  25. TEC DOC-564 (1990) Practical aspects of operating a neutron activation analysis laboratory, IAEA, Vienna, Austria

  26. Lederer CM, Shirley VS (1978) Table of isotopes. Wiley Interscience Pub, New York

    Google Scholar 

Download references

Acknowledgments

The authors thank FAPEMIG and the CNPq for their financial support.

Author information

Authors and Affiliations

  1. Centre for Development of Nuclear Technology (CDTN), Brazilian Commission for Nuclear Energy (CNEN), UFMG, Av. Antonio Carlos 6627, Belo Horizonte, Minas Gerais, CEP 31270-901, Brazil

    A. S. Leal

  2. Department of Chemistry, Federal University of Minas Gerais (UFMG), Antonio Carlos 6627, Belo Horizonte, Minas Gerais, CEP 31270-901, Brazil

    I. M. Marzano & E. C. Pereira-Maia

  3. Jožef Stefan Institute, Jamova cesta 39, 1000, Ljubljana, Slovenia

    R. Jacimovic

Authors
  1. A. S. Leal
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. M. Marzano
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. C. Pereira-Maia
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. Jacimovic
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. S. Leal.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Leal, A.S., Marzano, I.M., Pereira-Maia, E.C. et al. Investigation of the potential antitumor radioactive complex of platinum(II) with tetracycline. J Radioanal Nucl Chem 309, 85–89 (2016). https://doi.org/10.1007/s10967-016-4775-8

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10967-016-4775-8

Keywords

Search

Navigation