Skip to main content
SpringerLink
Log in

Tritiation of melatonin by several methods

  • Published:
Journal of Radioanalytical and Nuclear Chemistry Aims and scope Submit manuscript

Abstract

The hormone melatonin acts at several G protein-linked receptors to cause a myriad of significant physiological effects. The tritiation of melatonin at high specific activity and characterization of it with tritium NMR for biological testing is reported.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. A. B. Lerner, J. D. Case, Y. Takahashi, T. H. Lee, W. Mori, J. Am. Chem. Soc., 80 (1958) 2587.

    Article  CAS  Google Scholar 

  2. A. B. Lerner, J. D. Case, R. V. Heinzelman, J. Am. Chem. Soc., 81 (1959) 6084.

    Article  CAS  Google Scholar 

  3. J. E. Jan, M. B. Wasdell, M. D. Weiss, R. D. Freeman, Biol. Rhythm Res., 38 (2007) 85.

    Article  CAS  Google Scholar 

  4. P. Pevet, Lettre du Pharmacologue, 19 (2005) 145.

    CAS  Google Scholar 

  5. M. Sankaran, P. Subramanian, Indian J. Pharm. Sci., 67 (2005) 661.

    CAS  Google Scholar 

  6. P. E. Holtzheimer, C. B. Nemeroff, Exp. Opin. Pharmacotherapy, 7 (2006) 2323.

    Article  CAS  Google Scholar 

  7. F. Simko, L. Paulis, J. Pineal Res., 42 (2007) 319.

    Article  CAS  Google Scholar 

  8. P. A. Witt-Enderby, N. M. Radio, J. S. Doctor, V. L. Davis, J. Pineal Res., 41 (2006) 297.

    Article  CAS  Google Scholar 

  9. P. Alarma-Estrany, J. Pintor, Pharmacol. Ther., 113 (2007) 507.

    Article  CAS  Google Scholar 

  10. C. Ekmekcioglu, Biomed. Pharmacotherapy, 60 (2006) 97.

    Article  CAS  Google Scholar 

  11. P. Delagrange, J. Boutin, Chronobiol. Int., 23 (2006) 413.

    Article  CAS  Google Scholar 

  12. M. Somei, Y. Fukui, M. Hasegawa, N. Oshikiri, T. Hayashi, Heterocycles, 53 (2000) 1725.

    Article  CAS  Google Scholar 

  13. E. Duranti, B. Stankov, G. Spadoni, A. Duranti, V. Lucini, S. Casoni, G. Biella, F. Fraschini, Life Sci., 51 (1992) 479.

    Article  CAS  Google Scholar 

  14. O. Vakkuri, E. Lamsa, E. Rahkamaa, H. Ruotsalainen, J. Leppaluoto, Anal. Biochem., 142 (1984) 284.

    Article  CAS  Google Scholar 

  15. B. Withyachumnarnkul, M. Limpanawattanakul, W. Trakulrungsi, Life Sci., 38 (1986) 1757.

    Article  CAS  Google Scholar 

  16. G. Benitez-King, L. Huerto-Delgadillo, F. Anton-Tay, Life Sci., 53 (1993) 201.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. PerkinElmer Life and Analytical Sciences, Inc., 549 Albany St., Boston, Massachusetts, 02118, USA

    D. G. Ahern, J. C. Morrison & C. N. Filer

Authors
  1. D. G. Ahern
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. C. Morrison
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. N. Filer
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to C. N. Filer.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ahern, D.G., Morrison, J.C. & Filer, C.N. Tritiation of melatonin by several methods. J Radioanal Nucl Chem 279, 3–6 (2009). https://doi.org/10.1007/s10967-007-7166-3

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10967-007-7166-3

Keywords

Search

Navigation